非核苷逆轉錄酶抑制劑的製作方法

2024-01-22 10:39:15

專利名稱：非核苷逆轉錄酶抑制劑的製作方法
技術領域：
本發明一般涉及具有抗病毒活性且更具體的說是具有抗-HIV特性的化合物。
背景技術：
人免疫缺陷病毒(HIV)感染和相關疾病是全世界的一個主要公眾健康問題。一般認為屬於靈長類慢病毒科成員的逆轉錄病毒1型人免疫缺陷病毒(HIV-1)(DeClercq E(1994)《紐約科學院科學年鑑》(Annals of the New York Academy of Sciences)，724438-456；Barre-Sinoussi F(1996)《柳葉刀》(Lancet)，34831-35)是獲得性免疫缺陷症候群的(AIDS)病原體(Tarrago等《FASEB雜誌》(FASEBJournal)1994，8497-503)。AIDS是HIV-1反覆複製的結果(《生物化學》(Biochemistry)，63133-173)包括三種關鍵酶(i)蛋白酶(Prt)(von der Helm K(1996)《生物化學》(BiologicalChemistry)，377765-774)；(ii)逆轉錄酶(RT)(Hottiger等(1996)《生物化學》(Biological Chemistry)Hoppe-Seyler，37797-120)，即一種對逆轉錄病毒而言獨一無二的酶；和(iii)整合酶(Asante等(1999)《病毒研究的發展》(Advances in Virus Research)52351-369；Wlodawer A(1999)《病毒研究的發展》(Advances in Virus Research)52335-350；Esposito等(1999)《病毒研究的發展》(Advances inVirus Research)52319-333)。蛋白酶可以加工病毒前體多蛋白，整合酶可以將病毒基因組的雙鏈DNA形式整合入宿主DNA且RT是病毒基因組複製中的關鍵酶。在病毒複製中，RT起RNA-和DNA-依賴性DNA聚合酶作用而將單鏈RNA基因組整合成雙鏈DNA。由於病毒編碼的逆轉錄酶(RT)介導病毒天然再生過程中的特異性反應，所以抑制HIV RT是治療HIV感染和相關疾病的重要治療靶。
到1995年為止，美國批准的唯一藥物是RT核苷抑制劑(Smith等(1994)《臨床研究者》(Clinical Investigator)，17226-243)。從那時起，已經批准了兩種新類型的活性劑、即蛋白酶抑制劑和非核苷RT抑制劑(NNRTI)和超過10種以上的新藥(Johnson等(2000)《內科進展》(Advances in Internal Medicine)，45(1-40；Porche DJ(1999)《北美臨床護理》(Nursing Clinics of North America)，3495-112)。目前存在三種類型的可利用的藥物(1)原始的核苷RT抑制劑；(2)蛋白酶抑制劑；和(3)非核苷RT抑制劑(NNRTI)。核苷RT抑制劑包括齊多夫定、去羥肌苷(NIH)、扎西他濱(NIH)、拉米夫定(BioChem Pharma Inc)和阿巴卡韋(Glaxo Wellcomeplc)。參見JohnsonVA(1995)《感染性疾病雜誌》(Journal of Infectious Diseases)，171增刊2S140-S149；Venrura等(1999)《病毒學檔案》(Archivesof Virology)，144513-523；和Venrura等《病毒學檔案》(Archivesof Virology)1999，144(513-523)。批准的蛋白酶抑制劑藥物包括沙奎那韋(Hoffmann-La Roche Inc，Noble等(1996)《藥物》(Drugs)，521，93-112)、利託那韋(Abbott Laboratories)、茚地那韋(Merck Co Inc)、奈非那韋(Agouron Pharmaceuticals Inc)和氨普奈韋(Vertex Pharmaceuticals Inc)。批准的NNRTI包括奈韋拉平(Boehringer IngelHeim Corp，Grob等(1992)《AIDS研究和人逆轉錄病毒》(AIDS Research and Human Retrovirues)，8145-152；Pollard等(1998)《臨床治療》(Clinical Therapeutics)，201071-1092)、地拉(delavirdine)韋啶(Pharmacia Upjohn Inc，Freimuth WW(1996)《實驗藥物和生物學進展》(Advances inExperimental Medicine and Biology)，394279-289)和依法韋侖(DuPont Pharmaceuticals Co，Adkins等(1998)《藥物》(Drugs)，566，1055-1066)。卡普韋林是口服給藥的NNRTI治療劑候選物(BrownW.(2000)《最新抗感染研究藥物觀點》《Current Opinion inAnti-Infective Investigational Drugs》2(3)286-94)。
核苷和非核苷藥物均可以抑制RT(Venrura等(1999)《病毒學檔案》(Archives of Virology)，144513-523；Matthee等(1999)《植物藥》(Planta Medica)65493-506)。核苷抑制劑作為與天然底物競爭的競爭性抑制劑或作為鏈終止劑起作用(Mayers D(1996)AIDS10增刊1，S9-S13；Villahermosa等(1997)《生物化學》(Biochemistry)，3613223-13231；Klarmann等(2000)《生物化學雜誌》(Journal of Biological Chemistry)，275359-366)。包括齊多夫定、去羥肌苷和扎西他濱在內的核苷抑制劑仍然處於對HIV-1的一線療法。然而，過度應用這些藥物導致產生耐它們的HIV變體(Moyle GJ(1997)《抗微生物化療雜誌》(Journal ofAntimicrobial Chemotherapy)，406，765-777；Smith等(1994)《臨床研究者》(Clinical Investigator)17226-243)。這種耐受性的發生與編碼RT的HIV pol基因中的特異性點突變有關。
非核苷抑制劑通過與酶上非底物結合位點發生相互作用、即以變構方式起作用(Proudfoot JR(1998)《治療學專利中的最新觀點》(Current Opinion in Therapeutic Patents)，88，971-982；DeClercq E(1998)《抗病毒研究》《Antiviral Research》383，153-179；DeClercq E(1999)Farmaco 541-2，26-45；KatlamaC(1999)《國際臨床實踐雜誌》(International Journal of ClinicalPractice)，103增刊16-20；Pederson等(1999)《抗病毒化學和化療》(Antiviral Chemistry and Chemotherapy)10258-314)。NNRTI藥物目前已經在治療HIV-1感染的領域中贏得了一定位置(Spence等(1995)《科學》(Science)267988-993)，它通過與RT上的特異性位點發生相互作用而以非競爭性方式起作用，所述的RT上的特異性位點接近核苷抑制劑結合的活性位點，但與之不同。已經報導了幾種與非核苷抑制劑複合的HIV-1 RT的相關晶體結構，從而擴展了對這些抑制劑如何起作用的理解(Schafer-W等(1993)《藥物化學雜誌》(Journal of Medicinal Chemistry)36726-732)。
儘管靶向逆轉錄酶和蛋白酶的藥物得到廣泛應用且已經證實了它們的有效性，特別是在將它們聯用時，但是毒性和抗性菌株的出現已經限制了其應用(Palella等《新英格蘭藥物雜誌》(N.Bngl.J.Med.)(1998)338853-860；Richman，D.D.《自然》(Nature)(2001)410995-1001)。
已經證實與RT抑制劑的聯合療法在將病毒複製抑制到徹底水平持續時間期限方面高度有效。此外，與RT和Prt抑制劑的聯合療法已經在抑制HIV複製方面顯示出協同作用。令人遺憾的是，目前30-50％的患者因發生耐藥性、對複雜的給藥方案沒有依從性、藥動學相互作用、毒性和缺乏功效而對聯合療法失敗。因此，對與其它HIV抑制劑聯用產生協同作用的新HIV-1抑制劑存在需求。
能夠測定HIV RT存在、不存在或量的試驗方法在研究抑制劑和用於診斷HIV存在方面具有實際應用價值。
抑制HIV RT是本發明的目的。HIV RT抑制劑用於限制HIV建立和感染的發展並用於HIV RT的診斷試驗，這兩者均為本發明的其它目的。製備能夠抑制HIV RT的組合物也是本發明的目的。
存在對具有改善的抗病毒和藥動學特性的HIV RT抑制劑的需求，包括對HIV抗性發生的增強的活性、改善的口服生物利用度、較強的功效和延長的體內有效半衰期。新HIV RT抑制劑應對HIV突變株具有活性、具有不同的抗性分布、較少的副作用、較不複雜的給藥方案和口服活性。特別存在對複雜程度較低的劑量方案的需求，諸如一丸，每天一次。
改善藥物和其它活性劑轉運至靶細胞和組織已經成為多年大量研究的焦點。儘管已經進行了許多嘗試研發在體內和體外將生物活性分子導入細胞的有效方法，但是尚沒有證實它們完全令人滿意。使抑制性藥物與其胞囊靶結合程度最佳而同時將藥物的細胞間重分配、例如至相鄰細胞減少至最低限度通常是困難或無效的。
目前對患者經非腸道給藥的大部分活性劑是無法定向的，導致將所述活性劑全身轉運至並不必且通常是不需要這些活性劑的身體細胞和組織。這種情況可以產生不良的藥物副作用且通常限制可以給予的藥物的劑量(例如細胞毒性劑和其它抗癌或抗病毒藥)。通過比較發現，儘管一般將口服給藥看作是便利和經濟的給藥方法，但是口服給藥可以導致(a)藥物通過細胞和組織屏障、例如血液/腦、上皮、細胞膜吸收而產生不需要的全身分布或(b)藥物在胃腸道的短暫停留。因此，主要目的已經成為研發特別靶向至細胞和組織的活性劑的方法。這類方法的有益性包括避免了這類活性劑以不適當方式轉運至其它細胞和組織、諸如非感染細胞的一般性藥理作用。
可以使用使生物活性劑積蓄或停留在細胞內部的方法和組合物實現胞內靶向。
發明概述本發明提供了用於抑制HIV的組合物和方法。本發明的組合物包括咪唑環的碳原子上被硫基團取代並帶有至少一個膦酸酯基的新咪唑化合物。
因此，本發明包括具有通式I的化合物 其中A0為A1、A2或W3。本發明的化合物包括至少一個A1，它含有至少一個膦酸酯基。在另一個方面中，本發明包括具有通式II的化合物 其中A0為A1、A2或W3。通式II包括至少一個A1，它含有至少一個膦酸酯基。
本發明在一個方面中提供了化合物或進一步包括藥物上可接受的載體的組合物。
本發明在另一個方面中提供了已知經批准的膦酸酯類似物和實驗性非核苷RT抑制劑(NNRTI)，包括●卡普韋林-類膦酸酯NNRTI化合物；●PETT-類膦酸酯NNRTI化合物；●吡唑-類膦酸酯NNRTI化合物；●脲-PETT-類膦酸酯NNRTI化合物；●奈韋拉平(奈韋拉平(Nevaripine))-類膦酸酯NNRTI化合物；●喹唑啉酮-類膦酸酯NNRTI化合物；●依法韋侖-類膦酸酯NNRTI化合物；●二苯甲酮-類膦酸酯NNRTI化合物；●嘧啶-類膦酸酯NNRTI化合物；●SJ3366-類膦酸酯NNRTI化合物；●地拉韋啶-類膦酸酯NNRTI化合物；●乙米韋林-類膦酸酯NNRTI化合物；●洛韋胺-類膦酸酯NNRTI化合物；●UC781-類膦酸酯NNRTI化合物；及其類似物及其藥物上可接受的鹽、水合物和製劑。
在本發明的另一個方面中，使用包括下列步驟的方法抑制HIV逆轉錄酶(RT)的活性用本發明的化合物或組合物處理懷疑含有HIV RT的樣品。
本發明的另一個方面提供了用於抑制HIV RT活性的方法，該方法包括下列步驟使懷疑含有HIV RT的樣品與本發明組合物的實施方案接觸。
本發明的另一個方面提供了聯合用藥物，包括有效量的本發明化合物和第二種具有抗-HIV特性的化合物。
本發明的另一個方面提供了用於治療或預防受感染的動物的HIV感染症狀或作用的方法，該方法包括對所述的動物給予聯合用藥物、即用聯合用藥物治療所述動物的步驟，所述的聯合用藥物包括有效量的本發明化合物和第二種具有抗-HIV特性的化合物。
在其它方面中提供了本發明化合物的新合成方法。
發明詳述和典型實施方案現在涉及本發明的某些實施方案，在附圖描述、結構和通式中解釋了其實施例。儘管結合列舉的實施方案描述了本發明，但是應理解並非將本發明限定至這些實施方案。相反，本發明包括所有可選方案、修改方案和等同技術方案，它們均包括在權利要求定義的本發明範圍內。
定義除非另有說明，本文所用的下列術語和措詞具有如下含義術語″膦酸酯″和″膦酸酯基″指的是含有至少一個磷-碳鍵和至少一個磷-氧雙鍵的分子內的官能基或部分。磷原子進一步被氧、硫和氮取代基取代。本文定義的″膦酸酯″和″膦酸酯基″包括含有膦酸、膦酸一酯、膦酸二酯、膦酸醯胺化物(phosphonamidate)、膦酸二醯胺化物(phosphondiamidate)和硫代膦酸酯官能基的分子。
本文所用的術語″前體藥物″指的是在對生物系統給藥時作為自發化學反應、酶催化的化學反應、光解和/或代謝化學反應的結果產生藥物物質、即活性組分的任意化合物。前體藥物由此是治療活性化合物的共價修飾的類似物或潛在形式。
″前體藥物部分″指的是新陳代謝過程中、全身、細胞內通過水解、酶裂解或通過某些其它過程與活性抑制化合物分離的不穩定官能基(Bundgaard，Hans，「前體藥物的設計與應用」(″Design andApplication of Prodrugs″)-《藥物設計與開發教科書》(Textbookof Drug Design and Development)(1991)，P.Krogsgaard-Larsen和H.Bundgaard，Eds.Harwood Academic Publishers，pp.113-191)。能夠使用本發明化合物的膦酸酯前體藥物實施酶失活的機制的酶包括、但不限於醯胺酶、酯酶、微生物酶、磷脂酶、膽鹼酯酶和磷酸酶(phosphases)。前體藥物部分可以用於提高溶解性、吸收性和親油性以使藥物轉運、生物利用度和功效達到最佳。
典型的前體藥物部分包括水解敏感性或不穩定的醯氧基甲基酯-CH2OC(＝O)R9和醯氧基甲基碳酸酯-CH2OC(＝O)OR9，其中R9為C1-C6烷基、C1-C6取代的烷基、C6-C20芳基或C6-C20取代的芳基。醯氧基烷基酯首先用作羧酸的前體藥物策略且然後用於磷酸酯類和膦酸酯類，參見Farquhar等(1983)《藥物科學雜誌》(J.Pharm.Sci.)72324；另外參見美國專利US 4816570、US 4968788、US 5663159和US 5792756。隨後將醯氧基烷基酯用於使膦酸轉運通過細胞膜並提高口服生物利用度。醯氧基烷基酯的相似變化形式烷氧羰基氧基烷基酯(碳酸酯)也可以作為本發明聯合用藥物的化合物中的前體藥物部分提高口服生物利用度。典型的醯氧基甲基酯為新戊醯氧基甲氧基(POM)-CH2OC(＝O)C(CH3)3。典型的碳酸醯氧基甲酯前體藥物部分為新戊醯氧基碳酸酯(POC)-CH2OC(＝O)OC(CH3)3。
據報導磷基的芳香酯類、尤其是苯基酯類可提高口服生物利用度(DeLambert等(1994)《藥物化學雜誌》(J.Med.Chem.)37498)。還描述了含有與磷酸酯鄰位的羧酸酯的苯基酯類(Khamnei和Torrence，(1996)《藥物化學雜誌》(J.Med.Chem.)394109-4115)。據報導苄基酯類可產生母體膦酸。在某些情況中，鄰位或對位上的取代基可以加速水解。含有醯化或烷基化苯酚的苄基類似物可以通過酶、例如酯酶、氧化酶等生成酚類化合物，由此在苄型C-O鍵上發生裂解而產生磷酸和醌的甲基化物中間體。Mitchell等(1992)在J.Chem.Soc.Perkin Trans.12345、Brook等在WO 91/19721中描述了這類前體藥物的實例。已經描述了含有與苄亞甲基連接的羧酸酯的基團的其它苄型前體藥物(Glazier等WO 91/19721)。據報導含硫的前體藥物可用於膦酸酯藥物的胞內轉運。這些前酯類(proesters)含有乙硫基，其中硫羥基被醯基酯化或與另一個硫羥基合併成二硫化物。脫酯化或還原該二硫化物生成游離硫代中間體，其隨後分解成磷酸和環硫化物(Puech等(1993)《抗病毒研究》(Antiviral Res.)，22155-174；Benzaria等(1996)《藥物化學雜誌》(J.Med.Chem.)394958)。還將環狀膦酸酯類描述為含磷化合物的前體藥物(Erion等美國專利US 6312662)。
″藥物上可接受的前體藥物″指的是在宿主體內通過酶作用或通過一般的酸或鹼解(sovolysis)，代謝、例如水解或氧化成活性組分的化合物。本發明化合物的前體藥物的典型實例在該化合物的官能部分上帶有生物上不穩定的保護基。前體藥物包括可以氧化、還原、胺化、脫去醯氨基的、酯化、脫酯化、烷基化、脫烷基化、醯化、脫醯化、磷酸化、脫磷酸化或包括形成前體藥物上的化學鍵或打斷前體藥物上的化學鍵的其它官能基改變或轉化的化合物。
″保護基″指的是掩蔽或改變作為整體的官能基特性或化合物特性的化合物部分。保護基的化學亞結構可以廣泛改變。保護基的一個功能為用作合成母體藥物物質中的中間體。化學保護基和保護/脫保護策略是本領域眾所周知的。參見《有機化學中的保護基》(″ProtectiveGroups in Organic Chemistry″)，Theodora W.Greene(John Wiley Sons，Inc.，New York，1991。保護基通常用於掩蔽某些官能基的反應性以有助於所需化學的反應效率，例如以預訂和計劃的方式掩蔽和打斷化學鍵。保護化合物的官能基除可以改變被保護的官能基反應性外、還可以改變諸如極性、親油性(疏水性)這類其它物理特性以及可以通過常用的分析工具測定的其它特性。以化學方式保護的中間體自身可以具有生物活性或在生物上失活。
被保護的化合物還可以在體外和體內表現出改變的且在某些情況中表現出最佳特性，諸如通過細胞膜和耐酶降解或螯合。在這種作用中，具有所需治療作用的被保護的化合物可以稱作前體藥物。保護基的另一個功能是將母體藥物轉化成前體藥物，由此在體內前體藥物轉化時釋放母體藥物。因為化學前體藥物可以比母體藥物更有效地被吸收，所以前體藥物在體內可以具有大於母體藥物的功效。就化學中間體而言，在體外除去保護基；或就前體藥物而言，在體內除去保護基。由於使用了化學中間體，所以在脫保護後得到的產物、例如醇類是否是生理上可接受的並非特別重要，不過，一般來說，如果產物是藥理上無害的，那麼該產物更為理想。
涉及的本發明任意化合物還包括涉及的其生理上可接受的鹽。本發明化合物的生理上可接受的鹽包括來源於適宜鹼的鹽，諸如鹼金屬(例如鈉)鹽、鹼土金屬(例如鎂)鹽、銨鹽和NX4+(其中X為C1-C4烷基)鹽。氫原子或氨基的生理上可接受的鹽包括有機羧酸、有機磺酸和有機酸的鹽有機羧酸，諸如乙酸、苯甲酸、乳酸、富馬酸、酒石酸、馬來酸、丙二酸、蘋果酸、羥乙磺酸、乳糖酸和琥珀酸；有機磺酸，諸如甲磺酸、乙磺酸、苯磺酸和對甲苯磺酸；和無機酸，諸如鹽酸、硫酸、磷酸和氨基磺酸。羥基化合物的生理上可接受的鹽包括所述化合物的陰離子與適宜的陽離子、諸如Na+和NX4+(其中X獨立地選自H或C1-C4烷基)。
為了治療目的，本發明化合物活性組分的鹽應是生理上可接受的，即它們是來源於生理上可接受的酸或鹼的鹽。不過，例如，非生理上可接受的酸或鹼的鹽也用於製備或純化生理上可接受的化合物。所有的鹽、無論是否來源於生理上可接受的酸或鹼均屬於本發明的範圍。
″烷基″為含有正、仲、叔或環碳原子的C1-C18烴。實例為甲基(Me、-CH3)、乙基(Et、-CH2CH3)、1-丙基(n-Pr、正丙基、-CH2CH2CH3)、2-丙基(i-Pr、異丙基、-CH(CH3)2)、1-丁基(n-Bu、正丁基、-CH2CH2CH2CH3)、2-甲基-1-丙基(i-Bu、異丁基、-CH2CH(CH3)2)、2-丁基(s-Bu、仲丁基、-CH(CH3)CH2CH3)、2-甲基-2-丙基(t-Bu、叔丁基、-C(CH3)3)、1-戊基(正戊基、-CH2CH2CH2CH2CH3)、2-戊基(CH(CH3)CH2CH2CH3)、3-戊基(-CH(CH2CH3)2)、2-甲基-2-丁基(-C(CH3)2CH2CH3)、3-甲基-2-丁基(-CH(CH3)CH(CH3)2)、3-甲基-1-丁基(-CH2CH2CH(CH3)2)、2-甲基-1-丁基(-CH2CH(CH3)CH2CH3)、1-己基(-CH2CH2CH2CH2CH2CH3)、2-己基(-CH(CH3)CH2CH2CH2CH3)、3-己基(-CH(CH2CH3)(CH2CH2CH3))、2-甲基-2-戊基(-C(CH3)2CH2CH2CH3)、3-甲基-2-戊基(-CH(CH3)CH(CH3)CH2CH3)、4-甲基-2-戊基(-CH(CH3)CH2CH(CH3)2)、3-甲基-3-戊基(-C(CH3)(CH2CH3)2)、2-甲基-3-戊基(-CH(CH2CH3)CH(CH3)2)、2，3-二甲基-2-丁基(-C(CH3)2CH(CH3)2)、3，3-二甲基-2-丁基(-CH(CH3)C(CH3)3″鏈烯基″為含有正、仲、叔或環碳原子與至少一個不飽和位置、即碳-碳sp2雙鍵的C2-C18烴。實例包括、但不限於乙烯或乙烯基(-CH＝CH2)、烯丙基(-CH2CH＝CH2)、環戊烯基(-C5H7)和5-己烯基(-CH2CH2CH2CH2CH＝CH2)。
″炔基″為含有正、仲、叔或環碳原子與至少一個不飽和位置、即碳-碳sp三鍵的C2-C18烴。實例包括、但不限於炔(-C≡CH)和炔丙基(-CH2C≡CH)。
″亞烷基″指的是1-18個碳原子且帶有通過從母體烷的相同或兩個不同碳原子上除去兩個氫原子而衍生的兩個一價基中心的飽和支鏈或直鏈或環狀烴基。典型的亞烷基包括、但不限於亞甲基(-CH2-)、1，2-乙基(-CH2CH2-)、1，3-丙基(-CH2CH2CH2-)、1，4-丁基(-CH2CH2CH2CH2-)等。
″亞鏈烯基″指的是2-18個碳原子且帶有通過從母體烯的相同或兩個不同碳原子上除去兩個氫原子而衍生的兩個一價基中心的飽和支鏈或直鏈或環狀烴基。典型的亞鏈烯基包括、但不限於1，2-亞乙烯基(-CH＝CH-)。
″亞炔基″指的是2-18個碳原子且帶有通過從母體炔的相同或兩個不同碳原子上除去兩個氫原子而衍生的兩個一價基中心的飽和支鏈或直鏈或環狀烴基。典型的亞炔基包括、但不限於乙炔(-C≡C-)、炔丙基(-CH2C≡C-)和4-戊炔基(-CH2CH2CH2C≡CH-)。
″芳基″指的是通過從母體芳族環系的單碳原子上除去一個氫原子的6-20個碳原子的一價芳族烴基。典型的芳基包括、但不限於來源於苯、取代的苯、萘、蒽、聯苯等的基團。
″芳烷基″指的是非環烷基，其中與碳原子結合的氫原子之一、一般為末端或Sp3碳原子被芳基取代。典型的芳烷基包括、但不限於苄基、2-苯乙-1-基、2-苯乙烯-1-基、萘基甲基、2-萘基乙-1-基、2-萘基乙烯-1-基、萘並苄基、2-萘並苯乙-1-基等。芳烷基含有6-20個碳原子，例如芳烷基的烷基部分、包括烷基、鏈烯基或炔基為1-6個碳原子且芳基部分為5-14個碳原子。
″取代的烷基″、″取代的芳基″和″取代的方烷基″分別指的是一個或多個氫原子各自獨立地被取代基取代的烷基、芳基和芳烷基。典型的取代基包括、但不限於-X、-R、-O-、-OR、-SR、-S-、-NR2、-NR3、＝NR、-CX3、-CN、-OCN、-SCN、-N＝C＝O、-NCS、-NO、-NO2、＝N2、-N3、NC(＝O)R、-C(＝O)R、-C(＝O)NRR-S(＝O)2O-、-S(＝O)2OH、-S(＝O)2R、-OS(＝O)2OR、-S(＝O)2NR、-S(＝O)R、-OP(＝O)O2RR、-P(＝O)O2RR-P(＝O)(O-)2、-P(＝O)(OH)2、-C(＝O)R、-C(＝O)X、-C(S)R、-C(O)OR、-C(O)O-、-C(S)OR、-C(O)SR、-C(S)SR、-C(O)NRR、-C(S)NRR、-C(NR)NRR，其中X各自獨立為滷素F、Cl、Br或I；且R各自獨立為-H、烷基、芳基、雜環或前體藥物部分。亞烷基、亞鏈烯基和亞炔基也可以類似地被取代。
本文所用的″雜環″包括下列文獻中描述的那些雜環作為實例、但不限於它們Paquette，Leo A.；《現代雜環化學原理》(″Principlesof Modern Heterocyclic Chemistry″)(W.A.Benjamin，New York，1968)，，特別是第1、3、4、6、7和9章；《雜環化合物化學系列專刊》(″The Chemistry of Heterocyclic Compounds，A series ofMonographs″)(John Wiley Sons，New York，1950-現在)、特別是第13、14、16、19和28卷；和《美國化學協會雜誌》(J.Am.Chem.Soc.)(1960)825566。
雜環的實例包括如下實例、但並不限於它們吡啶基、二氫吡啶基、四氫吡啶基(哌啶基)、噻唑基、四氫苯硫基、硫氧化的四氫苯硫基。嘧啶基、呋喃基、噻吩基、吡咯基、吡唑基、咪唑基、四唑基、苯並呋喃基、硫茚基、吲哚基、亞吲哚基(indolenyl)、喹啉基、異喹啉基、苯並咪唑基、哌啶基、4-哌啶酮基、吡咯烷基、2-吡咯烷酮基、吡咯啉基、四氫呋喃基、四氫喹啉基、四氫異喹啉基、十氫喹啉基、八氫異喹啉基、吖辛因基(azocinyl)、三嗪基、6H-1，2，5-噻二嗪基、2H，6H-1，5，2-二噻嗪基、噻吩基、噻蒽基、吡喃基、異苯並呋喃基、色烯基、呫噸基、吩噁嗪基(phenoxathinyl)、2H-吡咯基、異噻唑基、異噁唑基、吡嗪基、噠嗪基、中氮茚基、異吲哚基、3H-吲哚基、、1H-吲唑基、嘌呤基、4H-喹嗪基、2，3-二氮雜萘基、1，5-二氮雜萘基、喹喔啉基、喹唑啉基、噌啉基、蝶啶基、4aH-咔唑基、β-咔啉基、菲啶基、吖啶基、嘧啶基、菲咯啉基、吩嗪基、吩噻嗪基、呋咱基、酚噁嗪基、異苯並二氫吡喃基、苯並二氫吡喃基、咪唑烷基、咪唑啉基、吡唑烷基、吡唑啉基、哌嗪基、二氫吲哚基、異二氫吲哚基、奎寧環基、嗎啉基、噁唑烷基、苯並三唑基、苯並異噁唑基、羥吲哚基、苯並噁唑啉基和靛紅醯基。
作為實例、但不受此限制，碳連接的雜環結合在吡啶的2、3、4、5或6位上、噠嗪的3、4、5或6位上、嘧啶的2、4、5或6位上、吡嗪的2、3、5或6位上、呋喃、四氫呋喃、噻吩、吡咯或四氫吡咯的2、3、4或5位上、噁唑、咪唑或噻唑的2、4或5位上、異噁唑、吡唑或異噻唑的3、4或5位上、氮丙啶的2或3位上、氮雜環丁烷的2、3或4位上、喹啉的2、3、4、5、6、7或8位上或異喹啉的1、3、4、5、6、7或8位上。更為典型的情況是，碳結合的雜環包括2-吡啶基、3-吡啶基、4-吡啶基、5-吡啶基、6-吡啶基、3-噠嗪基、4-噠嗪基、5-噠嗪基、6-噠嗪基、2-嘧啶基、4-嘧啶基、5-嘧啶基、6-嘧啶基、2-吡嗪基、3-吡嗪基、5-吡嗪基、6-吡嗪基、2-噻唑基、4-噻唑基或5-噻唑基。
作為實例、但不受此限制，氮連接的雜環結合在氮丙啶、氮雜環丁烷、吡咯、吡咯烷、2-吡咯啉、3-吡咯啉、咪唑、咪唑烷、2-咪唑啉、3-咪唑啉、吡唑、吡唑啉、2-吡唑啉、3-吡唑啉、哌啶、哌嗪、吲哚、二氫吲哚、1H-吲唑的1位上、異吲哚或異二氫吲哚的2位上、嗎啉的4位上和咔唑或β-咔啉的9位上。更為典型的情況是，氮結合的雜環包括1-吖丙啶基、1-氮雜環丁二烯基、1-吡咯基、1-咪唑基、1-吡唑基和1-哌啶基。
″碳環″指的是含有3-7個碳原子的作為單環的或7-12個碳原子作為二環的飽和、不飽和或芳族環。單環碳環含有3-6個環原子、更典型的為含有5或6個環原子。二環碳環含有例如排列為二環[4，5]、[5，5]、[5，6]或[6，6]系7-12個環原子或排列為二環[5，6]或[6，6]系的9或10個環原子。單環碳環的實例包括環丙基、環丁基、環戊基、1-環戊-1-烯基、1-環戊-2-烯基、1-環戊-3-烯基、環己基、1-環己-1-烯基、1-環己-2-烯基、1-環己-3-烯基、苯基、螺基(spiryl)和萘基。
″連接基(Linker)″或″連接物(Link)″指的是含有共價鍵的或使膦酸酯基與藥物共價結合的原子鏈化學部分。連接基包括通式I中所列的取代基A1和A3的部分或通式II中所列的取代基A1和A3的部分，它們包括如下部分諸如烷氧基(例如聚乙烯氧基、PEG、聚亞甲氧基)和烷氨基(例如聚亞乙基氨基，JeffamineTM)的重複單元和包括琥珀酸酯、琥珀酸亞胺、二甘醇酸酯、丙二酸酯和己醯胺在內的二酸酯和醯胺類。
本文所用的立體化學定義和規定一般遵循S.P.Parker，Ed.《McGraw-Hill化學術語辭典》(McGraw-Hill Dictionary of ChemicalTerms)(1984)McGraw-Hill Book Company，New York；和Eliel，E.和Wilen，S.《有機化合物立體化學》(Stereochemistry of OrganicCompunds)(1994)John Wiley Sons，Inc.，New York。許多有機化合物以旋光體存在，即它們具有使平面偏振光面旋轉的能力。在描述旋光化合物中，前綴D和L或R和S用於表示分子關於其手性中心的絕對構型。前綴d和l、D和L或(+)和(-)用於表示化合物使平面偏振光旋轉的現象，其中(-)或l指的是化合物為左旋。加(+)或d前綴的化合物為右旋。對指定的化學結構而言，這些稱作立體異構體的化合物是相同的，但它們彼此為鏡像。具體的立體異構體也可以稱作對映體且這類異構體的混合物通常稱作對映體混合物。對映體的5050混合物稱作外消旋混合物或外消旋物。術語″外消旋混合物″和″外消旋物″指的是等摩爾的兩種對映體混合物光學活性。
術語″手性″指的是具有鏡像配偶體不能重疊特性的分子，而術語″非手性″指的是對其配偶體具有可重疊鏡像的分子。
術語″立體異構體″指的是具有相同化學構成、但在原子或基團排列空間排列方面不同的化合物。
″非對映體″指的是帶有兩個或多個手性中心且其分子彼此為非鏡像的立體異構體。非對映體具有不同的物理特性，例如熔點、沸點、光譜特性和反應性。非對映體混合物可以在高分辨分析步驟、諸如電泳和色譜法中分離。
″對映體″指的是彼此為不能重疊鏡像的化合物的兩種立體異構體。
非核苷酸逆轉錄酶抑制劑(NNRTI)化合物本發明的化合物包括那些具有抗-HIV活性的化合物。這些化合物特別包括非核苷酸逆轉錄酶抑制劑(NNRTI)。本發明的化合物帶有膦酸酯基，它可以為前體藥物部分。
在本發明的一個實施方案中，鑑定了可以屬於引述的對比文件中所屬的範圍的化合物，它們屬於術語CLC(卡普韋林-類化合物)的定義範圍且進一步含有膦酸酯基，例如膦酸二酯、膦酸醯胺化物(phosphonamidate)-酯前體藥物或雙-膦酸醯胺化物(phosphonamidate)-酯(Jiang等US 2002/0173490 A1)。
如果本文所述的化合物被一個以上相同名稱的基團、例如″R1″或″R6a″取代，那麼應理解這些基團可以相同或不同，即每個基團被獨立地選擇。波浪線表示與鄰接基團、部分或原子連接的共價鍵位置。
本發明的化合物如下方案、實施例和權利要求中所列且包括通式I和通式II的化合物。通式I的化合物具有如下一般結構 本發明還包括下列通式 其中Z是CH或N
和
其中A為O、S或N(Rx)且X為O或S。
上述通式被一個或多個共價結合的A0基團取代，包括在任意或所有A0位置上的同時取代。
A0為A1、A2或W3，條件是化合物包括至少一個A1。通式I的典型實施方案包括Ia、Ib、Ic和Id
A1為 A2為 A3為
Y1獨立為O、S、N(Rx)、N(O)(Rx)、N(ORx)、N(O)(ORx)或N(N(Rx)(Rx))。
Y2獨立為鍵、O、N(Rx)、N(O)(Rx)、N(ORx)、N(O)(ORx)、N(N(Rx)(Rx))、-S(O)M2-或-S(O)M2-S(O)M2-。
Rx獨立為H、W3、保護基或下列通式 其中M1a、M1c和M1d獨立為0或1；M12c為0、1、2、3、4、5、6、7、8、9、10、11或12；且Ry獨立為H、W3、R2或保護基。
另一方面，Rx為下列基團 其中m1a、m1b、m1c、m1d和m1e獨立為0或1；m12c為0、1、2、3、4、5、6、7、8、9、10、11或12；Ry為H、W3、R2或保護基；條件是
如果m1a、m12c和m1d為0，那麼m1b、m1c和m1e為0；如果m1a和m12c為0且m1d不為0，那麼m1b和m1c為0；如果m1a和m1d為0且m12c不為0，那麼m1b以及m1c和m1e中至少一個為0；如果m1a為0且m12c和m1d不為0，那麼m1b為0；如果m12c和m1d為0且m1a不為0，那麼m1b、m1c和m1e中的至少兩個為0；如果m12c為0且m1a和m1d不為0，那麼m1b和m1c中至少一個為0；且如果m1d為0且m1a和m12c不為0，那麼m1c和m1e中的至少一個為0。
R1獨立為H或1-18個碳原子的烷基。
R2獨立為H、R1、R3或R4，其中R4各自獨立地被0-3個R3基團取代。或者，碳原子上的兩個R2基團共同形成環，即螺碳。例如，該環可以為環丙基、環丁基、環戊基或環己基。該環可以被0-3個R3基團取代。
R3為R3a、R3b、R3c或R3d，，條件是當R3與雜原子結合時，R3為R3c或R3d。
R3a為F、Cl、Br、I、-CN、N3或-NO2。
R3b為Y1。
R3c為-Rx、-N(Rx)(Rx)、-SRx、-S(O)Rx、-S(O)2Rx、-S(O)(ORx)、-S(O)2(ORx)、-OC(Y1)Rx、-OC(Y1)ORx、-OC(Y1)(N(Rx)(Rx))、-SC(Y1)Rx、-SC(Y1)ORx、-SC(Y1)(N(Rx)(Rx))、-N(Rx)C(Y1)Rx、-N(Rx)C(Y1)ORx或-N(Rx)C(Y1)(N(Rx)(Rx))。
R3d為-C(Y1)Rx、-C(Y1)ORx或-C(Y1)(N(Rx)(Rx))。
R4為1-18個碳原子的烷基、2-18個碳原子的鏈烯基或2-18個碳原子的炔基。
R5為R4，其中R4各自被0-3個R3基團取代。
R5a獨立為1-18個碳原子的亞烷基、2-18個碳原子的亞鏈烯基或2-18個碳原子的亞炔基，所述亞烷基、亞鏈烯基或亞炔基中的任意一個被0-3個R3基團取代。
W3為W4或W5。
W4為R5、-C(Y1)R5、-C(Y1)W5、-SO2R5或-SO2W5。
W5為碳環或雜環，其中W5獨立地被0-3個R2基團取代。
W3a為W4a或W5a。
W4a為R5a、-C(Y1)R5a、-C(Y1)W5a、-SO2R5a或-SO2W5a。
W5a為多價取代的碳環或雜環，其中W5a可以獨立地被0-3個R2基團、Y2和A3取代。
W6為獨立地被1、2或3個A3基團取代的W3。
M2為0、1或2；M12a為1、2、3、4、5、6、7、8、9、10、11或12；且M12b為0、1、2、3、4、5、6、7、8、9、10、11或12。
W5和W5a碳環以及W5和W5a雜環可以獨立地被0-3個R2基團取代。W5和W5a可以為含有單環或二環碳環或雜環的飽和、不飽和或芳族環。W5和W5a可以含有3-10個環原子，例如3-7個環原子。W5和W5a環在含有3個環原子時為飽和的、在含有4個環原子時為飽和或單-不飽和的、在含有5個環原子時為飽和或單-或二-不飽和的且在含有6個環原子時為飽和、單-或二-不飽和或芳香的。
W5或W5a雜環可以為含有3-7個環原子(2-6個碳原子和1-3個選自N、O、P和S的雜原子)的單環或含有7-10個環原子(4-9個碳原子和1-3個選自N、O、P和S的雜原子)的二環。W5雜環單環可以含有3-6個環原子(2-5個碳原子和1-2個選自N、O和S的雜原子)或5個或6個環原子(3-5個碳原子和1-2個選自N和S的雜原子)。W5和W5a雜環二環含有排列為二環[4，5]、[5，5]、[5，6]、或[6，6]系的7-10個環原子(6-9個碳原子和1-2個選自N、O和S的雜原子)或排列為雙環[5，6]或[6，6]系的9-10個環原子(8-9個碳原子和1-2個選自N和S的雜原子)。W5和W5a雜環可以通過碳、氮、硫或其它原子經穩定的共價鍵與Y2結合。
W5和W5a雜環包括例如、吡啶基、二氫吡啶基異構體、哌啶、噠嗪基、嘧啶基、吡嗪基、s-三嗪基、噁唑基、咪唑基、噻唑基、異噁唑基、吡唑基、異噻唑基、呋喃基、硫代呋喃基、噻吩基和吡咯基。W5和W5a還包括、但不限於如下實例 和 W5和W5a碳環和雜環可以獨立地被0-3個如上述所定義的R2基團取代，例如取代的W5和W5a碳環包括
取代的苯基碳環的實例包括包括 A1的實施方案包括
且其中一個或多個Y2為鍵，諸如 和 A3的實施方案包括其中M2為0，諸如
且其中M12b為1，Y1為氧且Y2b為氧(O)或氮(N(Rx))，諸如 A3的另一個實施方案包括 其中W5為碳環，諸如苯基或取代的苯基。這類實施方案包括
其中Y2b為O或N(Rx)；M12d為1、2、3、4、5、6、7或8；且所述的苯基碳環被0-3個R2基團取代。A3的這類實施方案包括苯基膦酸醯胺化物(phosphonamidate)-丙氨酸酯類和苯基膦酸-乳酸酯類 和 Rx的實施方案包括酯類、氨基甲酸酯類、碳酸酯類、硫酯類、醯胺類、硫代醯胺類和脲的基團 和 A2的實施方案包括其中W3為W5，諸如 另一方面，A2為苯基、取代的苯基、苄基、取代的苄基、吡啶基或取代的吡啶基。
通式Ic的實施方案包括 其中W4可以為R4，諸如異丙基。通式Ic的酯這類實施方案還可以包括 其中W5a為碳環或雜環且W5a任選和獨立地被1、2或3個R2基團取代。例如，W5a可以為3，5-二氯苯基。
通式Ic的實施方案可以包括其中A1為 n為1-18的整數；A3具有下列通式 且Y2c為O、N(Ry)或S。例如，R1可以為H且n可以為1。
通式Ib的實施方案包括
其中A1包括通過雜環連接基與咪唑氮連接的膦酸酯基，諸如 和 其中Y2b為O或N(R2)；且M12d為1、2、3、4、5、6、7或8。A3單元可以連接在W6碳環或雜環的任意一個位置上。
通式Ib的其它實施方案包括
PETT-類膦酸酯NNRTI化合物包括下列通式 和 吡唑-類膦酸酯NNRTI化合物包括下列通式 和
脲-PETT-類膦酸酯NNRTI化合物包括下列通式 和 奈韋拉平(Nevaripine)-類膦酸酯NNRTI化合物包括下列通式 和
喹唑啉酮-類膦酸酯NNRTI化合物包括下列通式 和 依法韋侖-類膦酸酯NNRTI化合物包括下列通式 和
二苯酮-類膦酸酯NNRTI化合物包括下列通式 和 嘧啶-類膦酸酯NNRTI化合物包括下列通式 和
SJ3366-類膦酸酯NNRTI化合物和乙米韋林-類膦酸酯NNRTI化合物包括下列通式 和 地拉韋啶-類膦酸酯NNRTI化合物包括下列通式 和
UC781-類膦酸酯NNRTI化合物包括下列通式 和 洛韋胺-類膦酸酯NNRTI化合物包括下列通式 和
通式II化合物包括具有一般結構的IIa和IIb，包括 其中A1為-(X2-(C(R2)(R2))m1-X3)m1-W3，且W3被1-3個A3基團取代。
A2為-(X2-(C(R2)(R2))m1-X3)m1-W3。
A3為-(X2-(C(R2)(R2))m1-X3)m1-P(Y1)(Y1R6a)(Y1R6a)。
X2和X3獨立為鍵、-O-、-N(R2)-、-N(OR2)-、-N(N(R2)(R2))-、-S-、-SO-或-SO2-。
Y1各自獨立為O、N(R2)、N(OR2)或N(N(R2)(R2))，其中Y1各自通過兩個單鍵或一個雙鍵結合。
R1獨立為H或1-12個碳原子的烷基。
R2獨立為H、R3或R4，其中R4各自獨立地被0-3個R3基團取代。另一方面，碳原子上的兩個R2基團共同形成環，即螺碳。例如，該環可以為環丙基、環丁基、環戊基或環己基。該環可以被0-3個R3基團取代。
R3獨立為F，Cl，Br，I，-CN，N3，-NO2，-OR6a，-OR1，-N(R1)2，-N(R1)(R6b)，-N(R6b)2，-SR1，-SR6a，-S(O)R1，-S(O)2R1，-S(O)OR1，-S(O)OR6a，-S(O)2OR1，-S(O)2OR6a，-C(O)OR1，-C(O)R6c，-C(O)OR6a，-OC(O)R1，-N(R1)(C(O)R1)，-N(R6b)(C(O)R1)，-N(R1)(C(O)OR1)，-N(R6b)(C(O)OR1)，-C(O)N(R1)2，-C(O)N(R6b)(R1)，-C(O)N(R6b)2，-C(NR1)(N(R1)2)，-C(N(R6b))(N(R1)2)，-C(N(R1))(N(R1)(R6b))，-C(N(R6b))(N(R1)(R6b))，-C(N(R1))(N(R6b)2)，-C(N(R6b))(N(R6b)2)，-N(R1)C(N(R1))(N(R1)2)，-N(R1)C(N(R1))(N(R1)(R6b))，-N(R1)C(N(R6b))(N(R1)2)，-N(R6b)C(N(R1))(N(R1)2)，-N(R6b)C(N(R6b))(N(R1)2)，-N(R6b)C(N(R1))(N(R1)(R6b))，-N(R1)C(N(R6b))(N(R1)(R6b))，-N(R1)C(N(R1))(N(R6b)2)，-N(R6b)C(N(R6b))(N(R1)(R6b))，-N(R6b)C(N(R1))(N(R6b)2)，-N(R1)C(N(R6b))(N(R6b)2)，-N(R6b)C(N(R6b))(N(R6b)2)，＝O，＝S，＝N(R1)，＝N(R6b)或W5。
R4獨立為1-12個碳原子的烷基、1-12個碳原子的鏈烯基或2-12個碳原子的炔基。
R5獨立為R4，其中R4各自被0-3個R3基團取代。
R5a獨立為1-12個碳原子的亞烷基、2-12個碳原子的亞鏈烯基和2-12個碳原子的亞炔基，該亞烷基、亞鏈烯基或亞炔基中的任意一個被0-3個R3基團取代；R6a獨立為H或成醚或酯的基團。
R6b獨立為H、氨基保護基或含羧基的化合物的殘基。
R6c獨立為H或含氨基的化合物的殘基。
W3為W4或W5。
W4為R5、-C(Y1)R5、-C(Y1)W5、-SO2R5或-SO2W5。
W5為碳環或雜環，其中W5獨立地被0-3個R2基團取代；W3a為W4a或W5a。
W4a為R5a、-C(Y1)R5a、-C(Y1)W5a、-SO2R5a或-SO2W5a。
W5a為碳環或雜環，其中W5獨立地被0-3個R2基團取代。
W6獨立地被1、2或3個A3基團取代。
m1獨立為0-12的整數，其中在A1、A2或A3的每一個實施方案中的所有m1的總和為12或12以下；且m2獨立為0-2的整數。
在通式II的一個實施方案中，A1為-(C(R2)(R2))m1-W3，其中W3被1個A3基團取代；A2為-(C(R2)(R2))m1-W3；且A3為-(C(R2)(R2))m1-P(Y1)(Y1R6a)(Y1R6a)列舉的典型化合物作為實例、但並不限於它們，將本發明的實施方案命名在下面的表格中(表100)。這些實施方案具有一般通式″MBF″
將MBF的各實施方案描述為取代的母核(Sc)，其中將該母核以一個數字命名並將各取代基依次以一個字母或一個數字命名。表1.1-1.5是用於形成表100中的實施方案母核的編制目錄。將每一個母核(Sc)以來自表1.1-1.5的一個數字命名給出且該命名首先出現在每一個實施方案的名稱中。類似地，表10.1-10.19和20.1-20.36中列出了選擇的連接基(Lg)和前體藥物(Pd1和Pd2)取代基，它們分別再次以字母或數字命名。
因此，表100中的每一個命名的實施方案以下列方式描述命名來自表1.1-1.5的母核的數字、後面是命名來自表10.1-10.19的連接基(Lg)的字母和命名來自表20.1-20.36的兩個前體藥物基團(Pd1和Pd2)。在圖式列表中，表100的每一個實施方案作為具有以下語法的名稱出現Sc.Lg.Pd1.Pd2因此，實施例27的結構58由12.AH.247.247表示。
Sc基團各自如具有代字符號(「～」)所示。代字符號是Sc與Lg共價結合的點。應理解連接基(Lg)的Q1和Q2不表示基團或原子，而為單純的連通命名。Q1是與母核(Sc)連接的共價鍵位置且Q2是與通式MBF的磷原子連接的共價鍵位置。每個前體藥物基團(Pd1和Pd2)在代字符號(tilda symbol)上與MBF的磷原子共價結合。表10.1-10.19和20.1-20.36中的某些實施方案可以作為字母和數字的組合(表10.1-10.19)或數字和字母的組合(表20.1-20.36)命名。例如，表10的條目中有BJ1和BJ2。在任何情況下，表10.1-10.19中的條目始終以字母開始。而表20.1-20.36中的條目始終以數字開始。當將母核(Sc)放在方括號(″[]″)內表示且共價鍵延伸至括號外時，Sc與Lg的共價結合點可以位於Sc上的任意可取代位置上。本文描述了對結合點的選擇。作為實例且並不限於它們，連接點選自方案和實施例中的某些連接點。
表1.1
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表1.4 表1.5
表10.1Q1-Q2 A
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表20.36
表20.37
表1001.B的前體藥物1.B.228.228；1.B.228.229；1.B.228.230；1.B.228.231；1.B.228.236；1.B.228.237；1.B.228.238；1.B.228.239；1.B.228.154；1.B.228.157；1.B.228.166；1.B.228.169；1.B.228.172；1.B.228.175；1.B.228.240；1.B.228.244；1.B.229.228；1.B.229.229；1.B.229.230；1.B.229.231；1.B.229.236；1.B.229.237；1.B.229.238；1.B.229.239；1.B.229.154；1.B.229.157；1.B.229.166；1.B.229.169；1.B.229.172；1.B.229.175；1.B.229.240；1.B.229.244；1.B.230.228；1.B.230.229；1.B.230.230；1.B.230.231；1.B.230.236；1.B.230.237；1.B.230.238；1.B.230.239；1.B.230.154；1.B.230.157；1.B.230.166；1.B.230.169；1.B.230.172；1.B.230.175；1.B.230.240；1.B.230.244；1.B.231.228；1.B.231.229；1.B.231.230；1.B.231.231；1.B.231.236；1.B.231.237；1.B.231.238；1.B.231.239；1.B.231.154；1.B.231.157；1.B.231.166；1.B.231.169；1.B.231.172；1.B.231.175；1.B.231.240；1.B.231.244；1.B.236.228；1.B.236.229；1.B.236.230；1.B.236.231；1.B.236.236；1.B.236.237；1.B.236.238；1.B.236.239；1.B.236.154；1.B.236.157；1.B.236.166；1.B.236.169；1.B.236.172；1.B.236.175；1.B.236.240；1.B.236.244；1.B.237.228；1.B.237.229；1.B.237.230；1.B.237.231；1.B.237.236；1.B.237.237；1.B.237.238；1.B.237.239；1.B.237.154；1.B.237.157；1.B.237.166；1.B.237.169；1.B.237.172；1.B.237.175；1.B.237.240；1.B.237.244；1.B.238.228；1.B.238.229；1.B.238.230；1.B.238.231；1.B.238.236；1.B.238.237；1.B.238.238；1.B.238.239；1.B.238.154；1.B.238.157；1.B.238.166；1.B.238.169；1.B.238.172；1.B.238.175；1.B.238.240；1.B.238.244；1.B.239.228；1.B.239.229；1.B.239.230；1.B.239.231；1.B.239.236；1.B.239.237；1.B.239.238；1.B.239.239；1.B.239.154；1.B.239.157；1.B.239.166；1.B.239.169；1.B.239.172；1.B.239.175；1.B.239.240；1.B.239.244；1.B.154.228；1.B.154.229；1.B.154.230；1.B.154.231；1.B.154.236；1.B.154.237；1.B.154.238；1.B.154.239；1.B.154.154；1.B.154.157；1.B.154.166；1.B.154.169；1.B.154.172；1.B.154.175；1.B.154.240；1.B.154.244；1.B.157.228；1.B.157.229；1.B.157.230；1.B.157.231；1.B.157.236；1.B.157.237；1.B.157.238；1.B.157.239；1.B.157.154；1.B.157.157；1.B.157.166；1.B.157.169；1.B.157.172；1.B.157.175；1.B.157.240；1.B.157.244；1.B.166.228；1.B.166.229；1.B.166.230；1.B.166.231；1.B.166.236；1.B.166.237；1.B.166.238；1.B.166.239；1.B.166.154；1.B.166.157；1.B.166.166；1.B.166.169；1.B.166.172；1.B.166.175；1.B.166.240；1.B.166.244；1.B.169.228；1.B.169.229；1.B.169.230；1.B.169.231；1.B.169.236；1.B.169.237；1.B.169.238；1.B.169.239；1.B.169.154；1.B.169.157；1.B.169.166；1.B.169.169；1.B.169.172；1.B.169.175；1.B.169.240；1.B.169.244；1.B.172.228；1.B.172.229；1.B.172.230；1.B.172.231；1.B.172.236；1.B.172.237；1.B.172.238；1.B.172.239；1.B.172.154；1.B.172.157；1.B.172.166；1.B.172.169；1.B.172.172；1.B.172.175；1.B.172.240；1.B.172.244；1.B.175.228；1.B.175.229；1.B.175.230；1.B.175.231；1.B.175.236；1.B.175.237；1.B.175.238；1.B.175.239；1.B.175.154；1.B.175.157；1.B.175.166；1.B.175.169；1.B.175.172；1.B.175.175；1.B.175.240；1.B.175.244；1.B.240.228；1.B.240.229；1.B.240.230；1.B.240.231；1.B.240.236；1.B.240.237；1.B.240.238；1.B.240.239；1.B.240.154；1.B.240.157；1.B.240.166；1.B.240.169；1.B.240.172；1.B.240.175；1.B.240.240；1.B.240.244；1.B.244.228；1.B.244.229；1.B.244.230；1.B.244.231；1.B.244.236；1.B.244.237；
1.B.244.238；1.B.244.239；1.B.244.154；1.B.244.157；1.B.244.166；1.B.244.169；1.B.244.172；1.B.244.175；1.B.244.240；1.B.244.244；1.D的前體藥物1.D.228.228；1.D.228.229；1.D.228.230；1.D.228.231；1.D.228.236；1.D.228.237；1.D.228.238；1.D.228.239；1.D.228.154；1.D.228.157；1.D.228.166；1.D.228.169；1.D.228.172；1.D.228.175；1.D.228.240；1.D.228.244；1.D.229.228；1.D.229.229；1.D.229.230；1.D.229.231；1.D.229.236；1.D.229.237；1.D.229.238；1.D.229.239；1.D.229.154；1.D.229.157；1.D.229.166；1.D.229.169；1.D.229.172；1.D.229.175；1.D.229.240；1.D.229.244；1.D.230.228；1.D.230.229；1.D.230.230；1.D.230.231；1.D.230.236；1.D.230.237；1.D.230.238；1.D.230.239；1.D.230.154；1.D.230.157；1.D.230.166；1.D.230.169；1.D.230.172；1.D.230.175；1.D.230.240；1.D.230.244；1.D.231.228；1.D.231.229；1.D.231.230；1.D.231.231；1.D.231.236；1.D.231.237；1.D.231.238；1.D.231.239；1.D.231.154；1.D.231.157；1.D.231.166；1.D.231.169；1.D.231.172；1.D.231.175；1.D.231.240；1.D.231.244；1.D.236.228；1.D.236.229；1.D.236.230；1.D.236.231；1.D.236.236；1.D.236.237；1.D.236.238；1.D.236.239；1.D.236.154；1.D.236.157；1.D.236.166；1.D.236.169；1.D.236.172；1.D.236.175；1.D.236.240；1.D.236.244；1.D.237.228；1.D.237.229；1.D.237.230；1.D.237.231；1.D.237.236；1.D.237.237；1.D.237.238；1.D.237.239；1.D.237.154；1.D.237.157；1.D.237.166；1.D.237.169；1.D.237.172；1.D.237.175；1.D.237.240；1.D.237.244；1.D.238.228；1.D.238.229；1.D.238.230；1.D.238.231；1.D.238.236；1.D.238.237；1.D.238.238；1.D.238.239；1.D.238.154；1.D.238.157；1.D.238.166；1.D.238.169；1.D.238.172；1.D.238.175；1.D.238.240；1.D.238.244；1.D.239.228；1.D.239.229；1.D.239.230；1.D.239.231；1.D.239.236；1.D.239.237；1.D.239.238；1.D.239.239；1.D.239.154；1.D.239.157；1.D.239.166；1.D.239.169；1.D.239.172；1.D.239.175；1.D.239.240；1.D.239.244；1.D.154.228；1.D.154.229；1.D.154.230；1.D.154.231；1.D.154.236；1.D.154.237；1.D.154.238；1.D.154.239；1.D.154.154；1.D.154.157；1.D.154.166；1.D.154.169；1.D.154.172；1.D.154.175；1.D.154.240；1.D.154.244；1.D.157.228；1.D.157.229；1.D.157.230；1.D.157.231；1.D.157.236；1.D.157.237；1.D.157.238；1.D.157.239；1.D.157.154；1.D.157.157；1.D.157.166；1.D.157.169；1.D.157.172；1.D.157.175；1.D.157.240；1.D.157.244；1.D.166.228；1.D.166.229；1.D.166.230；1.D.166.231；1.D.166.236；1.D.166.237；1.D.166.238；1.D.166.239；1.D.166.154；1.D.166.157；1.D.166.166；1.D.166.169；1.D.166.172；1.D.166.175；1.D.166.240；1.D.166.244；1.D.169.228；1.D.169.229；1.D.169.230；1.D.169.231；1.D.169.236；1.D.169.237；1.D.169.238；1.D.169.239；1.D.169.154；1.D.169.157；1.D.169.166；1.D.169.169；1.D.169.172；1.D.169.175；1.D.169.240；1.D.169.244；1.D.172.228；1.D.172.229；1.D.172.230；1.D.172.231；1.D.172.236；1.D.172.237；1.D.172.238；1.D.172.239；1.D.172.154；1.D.172.157；1.D.172.166；1.D.172.169；1.D.172.172；1.D.172.175；1.D.172.240；1.D.172.244；1.D.175.228；1.D.175.229；1.D.175.230；1.D.175.231；1.D.175.236；1.D.175.237；1.D.175.238；1.D.175.239；1.D.175.154；1.D.175.157；1.D.175.166；1.D.175.169；1.D.175.172；1.D.175.175；1.D.175.240；1.D.175.244；1.D.240.228；1.D.240.229；1.D.240.230；1.D.240.231；1.D.240.236；1.D.240.237；1.D.240.238；1.D.240.239；1.D.240.154；1.D.240.157；1.D.240.166；1.D.240.169；1.D.240.172；1.D.240.175；1.D.240.240；1.D.240.244；1.D.244.228；1.D.244.229；1.D.244.230；1.D.244.231；1.D.244.236；1.D.244.237；
1.D.244.238；1.D.244.239；1.D.244.154；1.D.244.157；1.D.244.166；1.D.244.169；1.D.244.172；1.D.244.175；1.D.244.240；1.D.244.244；1.E的前體藥物1.E.228.228；1.E.228.229；1.E.228.230；1.E.228.231；1.E.228.236；1.E.228.237；1.E.228.238；1.E.228.239；1.E.228.154；1.E.228.157；1.E.228.166；1.E.228.169；1.E.228.172；1.E.228.175；1.E.228.240；1.E.228.244；1.E.229.228；1.E.229.229；1.E.229.230；1.E.229.231；1.E.229.236；1.E.229.237；1.E.229.238；1.E.229.239；1.E.229.154；1.E.229.157；1.E.229.166；1.E.229.169；1.E.229.172；1.E.229.175；1.E.229.240；1.E.229.244；1.E.230.228；1.E.230.229；1.E.230.230；1.E.230.231；1.E.230.236；1.E.230.237；1.E.230.238；1.E.230.239；1.E.230.154；1.E.230.157；1.E.230.166；1.E.230.169；1.E.230.172；1.E.230.175；1.E.230.240；1.E.230.244；1.E.231.228；1.E.231.229；1.E.231.230；1.E.231.231；1.E.231.236；1.E.231.237；1.E.231.238；1.E.231.239；1.E.231.154；1.E.231.157；1.E.231.166；1.E.231.169；1.E.231.172；1.E.231.175；1.E.231.240；1.E.231.244；1.E.236.228；1.E.236.229；1.E.236.230；1.E.236.231；1.E.236.236；1.E.236.237；1.E.236.238；1.E.236.239；1.E.236.154；1.E.236.157；1.E.236.166；1.E.236.169；1.E.236.172；1.E.236.175；1.E.236.240；1.E.236.244；1.E.237.228；1.E.237.229；1.E.237.230；1.E.237.231；1.E.237.236；1.E.237.237；1.E.237.238；1.E.237.239；1.E.237.154；1.E.237.157；1.E.237.166；1.E.237.169；1.E.237.172；1.E.237.175；1.E.237.240；1.E.237.244；1.E.238.228；1.E.238.229；1.E.238.230；1.E.238.231；1.E.238.236；1.E.238.237；1.E.238.238；1.E.238.239；1.E.238.154；1.E.238.157；1.E.238.166；1.E.238.169；1.E.238.172；1.E.238.175；1.E.238.240；1.E.238.244；1.E.239.228；1.E.239.229；1.E.239.230；1.E.239.231；1.E.239.236；1.E.239.237；1.E.239.238；1.E.239.239；1.E.239.154；1.E.239.157；1.E.239.166；1.E.239.169；1.E.239.172；1.E.239.175；1.E.239.240；1.E.239.244；1.E.154.228；1.E.154.229；1.E.154.230；1.E.154.231；1.E.154.236；1.E.154.237；1.E.154.238；1.E.154.239；1.E.154.154；1.E.154.157；1.E.154.166；1.E.154.169；1.E.154.172；1.E.154.175；1.E.154.240；1.E.154.244；1.E.157.228；1.E.157.229；1.E.157.230；1.E.157.231；1.E.157.236；1.E.157.237；1.E.157.238；1.E.157.239；1.E.157.154；1.E.157.157；1.E.157.166；1.E.157.169；1.E.157.172；1.E.157.175；1.E.157.240；1.E.157.244；1.E.166.228；1.E.166.229；1.E.166.230；1.E.166.231；1.E.166.236；1.E.166.237；1.E.166.238；1.E.166.239；1.E.166.154；1.E.166.157；1.E.166.166；1.E.166.169；1.E.166.172；1.E.166.175；1.E.166.240；1.E.166.244；1.E.169.228；1.E.169.229；1.E.169.230；1.E.169.231；1.E.169.236；1.E.169.237；1.E.169.238；1.E.169.239；1.E.169.154；1.E.169.157；1.E.169.166；1.E.169.169；1.E.169.172；1.E.169.175；1.E.169.240；1.E.169.244；1.E.172.228；1.E.172.229；1.E.172.230；1.E.172.231；1.E.172.236；1.E.172.237；1.E.172.238；1.E.172.239；1.E.172.154；1.E.172.157；1.E.172.166；1.E.172.169；1.E.172.172；1.E.172.175；1.E.172.240；1.E.172.244；1.E.175.228；1.E.175.229；1.E.175.230；1.E.175.231；1.E.175.236；1.E.175.237；1.E.175.238；1.E.175.239；1.E.175.154；1.E.175.157；1.E.175.166；1.E.175.169；1.E.175.172；1.E.175.175；1.E.175.240；1.E.175.244；1.E.240.228；1.E.240.229；1.E.240.230；1.E.240.231；1.E.240.236；1.E.240.237；1.E.240.238；1.E.240.239；1.E.240.154；1.E.240.157；1.E.240.166；1.E.240.169；1.E.240.172；1.E.240.175；1.E.240.240；1.E.240.244；1.E.244.228；1.E.244.229；1.E.244.230；1.E.244.231；1.E.244.236；1.E.244.237；
1.E.244.238；1.E.244.239；1.E.244.154；1.E.244.157；1.E.244.166；1.E.244.169；1.E.244.172；1.E.244.175；1.E.244.240；1.E.244.244；1.G的前體藥物1.G.228.228；1.G.228.229；1.G.228.230；1.G.228.231；1.G.228.236；1.G.228.237；1.G.228.238；1.G.228.239；1.G.228.154；1.G.228.157；1.G.228.166；1.G.228.169；1.G.228.172；1.G.228.175；1.G.228.240；1.G.228.244；1.G.229.228；1.G.229.229；1.G.229.230；1.G.229.231；1.G.229.236；1.G.229.237；1.G.229.238；1.G.229.239；1.G.229.154；1.G.229.157；1.G.229.166；1.G.229.169；1.G.229.172；1.G.229.175；1.G.229.240；1.G.229.244；1.G.230.228；1.G.230.229；1.G.230.230；1.G.230.231；1.G.230.236；1.G.230.237；1.G.230.238；1.G.230.239；1.G.230.154；1.G.230.157；1.G.230.166；1.G.230.169；1.G.230.172；1.G.230.175；1.G.230.240；1.G.230.244；1.G.231.228；1.G.231.229；1.G.231.230；1.G.231.231；1.G.231.236；1.G.231.237；1.G.231.238；1.G.231.239；1.G.231.154；1.G.231.157；1.G.231.166；1.G.231.169；1.G.231.172；1.G.231.175；1.G.231.240；1.G.231.244；1.G.236.228；1.G.236.229；1.G.236.230；1.G.236.231；1.G.236.236；1.G.236.237；1.G.236.238；1.G.236.239；1.G.236.154；1.G.236.157；1.G.236.166；1.G.236.169；1.G.236.172；1.G.236.175；1.G.236.240；1.G.236.244；1.G.237.228；1.G.237.229；1.G.237.230；1.G.237.231；1.G.237.236；1.G.237.237；1.G.237.238；1.G.237.239；1.G.237.154；1.G.237.157；1.G.237.166；1.G.237.169；1.G.237.172；1.G.237.175；1.G.237.240；1.G.237.244；1.G.238.228；1.G.238.229；1.G.238.230；1.G.238.231；1.G.238.236；1.G.238.237；1.G.238.238；1.G.238.239；1.G.238.154；1.G.238.157；1.G.238.166；1.G.238.169；1.G.238.172；1.G.238.175；1.G.238.240；1.G.238.244；1.G.239.228；1.G.239.229；1.G.239.230；1.G.239.231；1.G.239.236；1.G.239.237；1.G.239.238；1.G.239.239；1.G.239.154；1.G.239.157；1.G.239.166；1.G.239.169；1.G.239.172；1.G.239.175；1.G.239.240；1.G.239.244；1.G.154.228；1.G.154.229；1.G.154.230；1.G.154.231；1.G.154.236；1.G.154.237；1.G.154.238；1.G.154.239；1.G.154.154；1.G.154.157；1.G.154.166；1.G.154.169；1.G.154.172；1.G.154.175；1.G.154.240；1.G.154.244；1.G.157.228；1.G.157.229；1.G.157.230；1.G.157.231；1.G.157.236；1.G.157.237；1.G.157.238；1.G.157.239；1.G.157.154；1.G.157.157；1.G.157.166；1.G.157.169；1.G.157.172；1.G.157.175；1.G.157.240；1.G.157.244；1.G.166.228；1.G.166.229；1.G.166.230；1.G.166.231；1.G.166.236；1.G.166.237；1.G.166.238；1.G.166.239；1.G.166.154；1.G.166.157；1.G.166.166；1.G.166.169；1.G.166.172；1.G.166.175；1.G.166.240；1.G.166.244；1.G.169.228；1.G.169.229；1.G.169.230；1.G.169.231；1.G.169.236；1.G.169.237；1.G.169.238；1.G.169.239；1.G.169.154；1.G.169.157；1.G.169.166；1.G.169.169；1.G.169.172；1.G.169.175；1.G.169.240；1.G.169.244；1.G.172.228；1.G.172.229；1.G.172.230；1.G.172.231；1.G.172.236；1.G.172.237；1.G.172.238；1.G.172.239；1.G.172.154；1.G.172.157；1.G.172.166；1.G.172.169；1.G.172.172；1.G.172.175；1.G.172.240；1.G.172.244；1.G.175.228；1.G.175.229；1.G.175.230；1.G.175.231；1.G.175.236；1.G.175.237；1.G.175.238；1.G.175.239；1.G.175.154；1.G.175.157；1.G.175.166；1.G.175.169；1.G.175.172；1.G.175.175；1.G.175.240；1.G.175.244；1.G.240.228；1.G.240.229；1.G.240.230；1.G.240.231；1.G.240.236；1.G.240.237；1.G.240.238；1.G.240.239；1.G.240.154；1.G.240.157；1.G.240.166；1.G.240.169；1.G.240.172；1.G.240.175；1.G.240.240；1.G.240.244；1.G.244.228；1.G.244.229；1.G.244.230；1.G.244.231；1.G.244.236；1.G.244.237；
1.G.244.238；1.G.244.239；1.G.244.154；1.G.244.157；1.G.244.166；1.G.244.169；1.G.244.172；1.G.244.175；1.G.244.240；1.G.244.244；1.I的前體藥物1.I.228.228；1.I.228.229；1.I.228.230；1.I.228.231；1.I.228.236；1.I.228.237；1.I.228.238；1.I.228.239；1.I.228.154；1.I.228.157；1.I.228.166；1.I.228.169；1.I.228.172；1.I.228.175；1.I.228.240；1.I.228.244；1.I.229.228；1.I.229.229；1.I.229.230；1.I.229.231；1.I.229.236；1.I.229.237；1.I.229.238；1.I.229.239；1.I.229.154；1.I.229.157；1.I.229.166；1.I.229.169；1.I.229.172；1.I.229.175；1.I.229.240；1.I.229.244；1.I.230.228；1.I.230.229；1.I.230.230；1.I.230.231；1.I.230.236；1.I.230.237；1.I.230.238；1.I.230.239；1.I.230.154；1.I.230.157；1.I.230.166；1.I.230.169；1.I.230.172；1.I.230.175；1.I.230.240；1.I.230.244；1.I.231.228；1.I.231.229；1.I.231.230；1.I.231.231；1.I.231.236；1.I.231.237；1.I.231.238；1.I.231.239；1.I.231.154；1.I.231.157；1.I.231.166；1.I.231.169；1.I.231.172；1.I.231.175；1.I.231.240；1.I.231.244；1.I.236.228；1.I.236.229；1.I.236.230；1.I.236.231；1.I.236.236；1.I.236.237；1.I.236.238；1.I.236.239；1.I.236.154；1.I.236.157；1.I.236.166；1.I.236.169；1.I.236.172；1.I.236.175；1.I.236.240；1.I.236.244；1.I.237.228；1.I.237.229；1.I.237.230；1.I.237.231；1.I.237.236；1.I.237.237；1.I.237.238；1.I.237.239；1.I.237.154；1.I.237.157；1.I.237.166；1.I.237.169；1.I.237.172；1.I.237.175；1.I.237.240；1.I.237.244；1.I.238.228；1.I.238.229；1.I.238.230；1.I.238.231；1.I.238.236；1.I.238.237；1.I.238.238；1.I.238.239；1.I.238.154；1.I.238.157；1.I.238.166；1.I.238.169；1.I.238.172；1.I.238.175；1.I.238.240；1.I.238.244；1.I.239.228；1.I.239.229；1.I.239.230；1.I.239.231；1.I.239.236；1.I.239.237；1.I.239.238；1.I.239.239；1.I.239.154；1.I.239.157；1.I.239.166；1.I.239.169；1.I.239.172；1.I.239.175；1.I.239.240；1.I.239.244；1.I.154.228；1.I.154.229；1.I.154.230；1.I.154.231；1.I.154.236；1.I.154.237；1.I.154.238；1.I.154.239；1.I.154.154；1.I.154.157；1.I.154.166；1.I.154.169；1.I.154.172；1.I.154.175；1.I.154.240；1.I.154.244；1.I.157.228；1.I.157.229；1.I.157.230；1.I.157.231；1.I.157.236；1.I.157.237；1.I.157.238；1.I.157.239；1.I.157.154；1.I.157.157；1.I.157.166；1.I.157.169；1.I.157.172；1.I.157.175；1.I.157.240；1.I.157.244；1.I.166.228；1.I.166.229；1.I.166.230；1.I.166.231；1.I.166.236；1.I.166.237；1.I.166.238；1.I.166.239；1.I.166.154；1.I.166.157；1.I.166.166；1.I.166.169；1.I.166.172；1.I.166.175；1.I.166.240；1.I.166.244；1.I.169.228；1.I.169.229；1.I.169.230；1.I.169.231；1.I.169.236；1.I.169.237；1.I.169.238；1.I.169.239；1.I.169.154；1.I.169.157；1.I.169.166；1.I.169.169；1.I.169.172；1.I.169.175；1.I.169.240；1.I.169.244；1.I.172.228；1.I.172.229；1.I.172.230；1.I.172.231；1.I.172.236；1.I.172.237；1.I.172.238；1.I.172.239；1.I.172.154；1.I.172.157；1.I.172.166；1.I.172.169；1.I.172.172；1.I.172.175；1.I.172.240；1.I.172.244；1.I.175.228；1.I.175.229；1.I.175.230；1.I.175.231；1.I.175.236；1.I.175.237；1.I.175.238；1.I.175.239；1.I.175.154；1.I.175.157；1.I.175.166；1.I.175.169；1.I.175.172；1.I.175.175；1.I.175.240；1.I.175.244；1.I.240.228；1.I.240.229；1.I.240.230；1.I.240.231；1.I.240.236；1.I.240.237；1.I.240.238；1.I.240.239；1.I.240.154；1.I.240.157；1.I.240.166；1.I.240.169；1.I.240.172；1.I.240.175；1.I.240.240；1.I.240.244；1.I.244.228；1.I.244.229；1.I.244.230；1.I.244.231；1.I.244.236；1.I.244.237；1.I.244.238；1.I.244.239；1.I.244.154；1.I.244.157；1.I.244.166；1.I.244.169；1.I.244.172；1.I.244.175；1.I.244.240；1.I.244.244；1.J的前體藥物1.J.228.228；1.J.228.229；1.J.228.230；1.J.228.231；1.J.228.236；1.J.228.237；1.J.228.238；1.J.228.239；1.J.228.154；1.J.228.157；1.J.228.166；1.J.228.169；1.J.228.172；1.J.228.175；1.J.228.240；1.J.228.244；1.J.229.228；1.J.229.229；1.J.229.230；1.J.229.231；1.J.229.236；
1.J.229.237；1.J.229.238；1.J.229.239；1.J.229.154；1.J.229.157；1.J.229.166；1.J.229.169；1.J.229.172；1.J.229.175；1.J.229.240；1.J.229.244；1.J.230.228；1.J.230.229；1.J.230.230；1.J.230.231；1.J.230.236；1.J.230.237；1.J.230.238；1.J.230.239；1.J.230.154；1.J.230.157；1.J.230.166；1.J.230.169；1.J.230.172；1.J.230.175；1.J.230.240；1.J.230.244；1.J.231.228；1.J.231.229；1.J.231.230；1.J.231.231；1.J.231.236；1.J.231.237；1.J.231.238；1.J.231.239；1.J.231.154；1.J.231.157；1.J.231.166；1.J.231.169；1.J.231.172；1.J.231.175；1.J.231.240；1.J.231.244；1.J.236.228；1.J.236.229；1.J.236.230；1.J.236.231；1.J.236.236；1.J.236.237；1.J.236.238；1.J.236.239；1.J.236.154；1.J.236.157；1.J.236.166；1.J.236.169；1.J.236.172；1.J.236.175；1.J.236.240；1.J.236.244；1.J.237.228；1.J.237.229；1.J.237.230；1.J.237.231；1.J.237.236；1.J.237.237；1.J.237.238；1.J.237.239；1.J.237.154；1.J.237.157；1.J.237.166；1.J.237.169；1.J.237.172；1.J.237.175；1.J.237.240；1.J.237.244；1.J.238.228；1.J.238.229；1.J.238.230；1.J.238.231；1.J.238.236；1.J.238.237；1.J.238.238；1.J.238.239；1.J.238.154；1.J.238.157；1.J.238.166；1.J.238.169；1.J.238.172；1.J.238.175；1.J.238.240；1.J.238.244；1.J.239.228；1.J.239.229；1.J.239.230；1.J.239.231；1.J.239.236；1.J.239.237；1.J.239.238；1.J.239.239；1.J.239.154；1.J.239.157；1.J.239.166；1.J.239.169；1.J.239.172；1.J.239.175；1.J.239.240；1.J.239.244；1.J.154.228；1.J.154.229；1.J.154.230；1.J.154.231；1.J.154.236；1.J.154.237；1.J.154.238；1.J.154.239；1.J.154.154；1.J.154.157；1.J.154.166；1.J.154.169；1.J.154.172；1.J.154.175；1.J.154.240；1.J.154.244；1.J.157.228；1.J.157.229；1.J.157.230；1.J.157.231；1.J.157.236；1.J.157.237；1.J.157.238；1.J.157.239；1.J.157.154；1.J.157.157；1.J.157.166；1.J.157.169；1.J.157.172；1.J.157.175；1.J.157.240；1.J.157.244；1.J.166.228；1.J.166.229；1.J.166.230；1.J.166.231；1.J.166.236；1.J.166.237；1.J.166.238；1.J.166.239；1.J.166.154；1.J.166.157；1.J.166.166；1.J.166.169；1.J.166.172；1.J.166.175；1.J.166.240；1.J.166.244；1.J.169.228；1.J.169.229；1.J.169.230；1.J.169.231；1.J.169.236；1.J.169.237；1.J.169.238；1.J.169.239；1.J.169.154；1.J.169.157；1.J.169.166；1.J.169.169；1.J.169.172；1.J.169.175；1.J.169.240；1.J.169.244；1.J.172.228；1.J.172.229；1.J.172.230；1.J.172.231；1.J.172.236；1.J.172.237；1.J.172.238；1.J.172.239；1.J.172.154；1.J.172.157；1.J.172.166；1.J.172.169；1.J.172.172；1.J.172.175；1.J.172.240；1.J.172.244；1.J.175.228；1.J.175.229；1.J.175.230；1.J.175.231；1.J.175.236；1.J.175.237；1.J.175.238；1.J.175.239；1.J.175.154；1.J.175.157；1.J.175.166；1.J.175.169；1.J.175.172；1.J.175.175；1.J.175.240；1.J.175.244；1.J.240.228；1.J.240.229；1.J.240.230；1.J.240.231；1.J.240.236；1.J.240.237；1.J.240.238；1.J.240.239；1.J.240.154；1.J.240.157；1.J.240.166；1.J.240.169；1.J.240.172；1.J.240.175；1.J.240.240；1.J.240.244；1.J.244.228；1.J.244.229；1.J.244.230；1.J.244.231；1.J.244.236；1.J.244.237；1.J.244.238；1.J.244.239；1.J.244.154；1.J.244.157；1.J.244.166；1.J.244.169；1.J.244.172；1.J.244.175；1.J.244.240；1.J.244.244；1.L的前體藥物1.L.228.228；1.L.228.229；1.L.228.230；1.L.228.231；1.L.228.236；1.L.228.237；1.L.228.238；1.L.228.239；1.L.228.154；1.L.228.157；1.L.228.166；1.L.228.169；1.L.228.172；1.L.228.175；1.L.228.240；1.L.228.244；1.L.229.228；1.L.229.229；1.L.229.230；1.L.229.231；1.L.229.236；1.L.229.237；1.L.229.238；1.L.229.239；1.L.229.154；1.L.229.157；1.L.229.166；1.L.229.169；1.L.229.172；1.L.229.175；1.L.229.240；1.L.229.244；1.L.230.228；1.L.230.229；1.L.230.230；1.L.230.231；1.L.230.236；1.L.230.237；1.L.230.238；1.L.230.239；1.L.230.154；1.L.230.157；1.L.230.166；1.L.230.169；1.L.230.172；1.L.230.175；1.L.230.240；1.L.230.244；1.L.231.228；1.L.231.229；1.L.231.230；1.L.231.231；1.L.231.236；1.L.231.237；1.L.231.238；1.L.231.239；1.L.231.154；1.L.231.157；1.L.231.166；1.L.231.169；
1.L.231.172；1.L.231.175；1.L.231.240；1.L.231.244；1.L.236.228；1.L.236.229；1.L.236.230；1.L.236.231；1.L.236.236；1.L.236.237；1.L.236.238；1.L.236.239；1.L.236.154；1.L.236.157；1.L.236.166；1.L.236.169；1.L.236.172；1.L.236.175；1.L.236.240；1.L.236.244；1.L.237.228；1.L.237.229；1.L.237.230；1.L.237.231；1.L.237.236；1.L.237.237；1.L.237.238；1.L.237.239；1.L.237.154；1.L.237.157；1.L.237.166；1.L.237.169；1.L.237.172；1.L.237.175；1.L.237.240；1.L.237.244；1.L.238.228；1.L.238.229；1.L.238.230；1.L.238.231；1.L.238.236；1.L.238.237；1.L.238.238；1.L.238.239；1.L.238.154；1.L.238.157；1.L.238.166；1.L.238.169；1.L.238.172；1.L.238.175；1.L.238.240；1.L.238.244；1.L.239.228；1.L.239.229；1.L.239.230；1.L.239.231；1.L.239.236；1.L.239.237；1.L.239.238；1.L.239.239；1.L.239.154；1.L.239.157；1.L.239.166；1.L.239.169；1.L.239.172；1.L.239.175；1.L.239.240；1.L.239.244；1.L.154.228；1.L.154.229；1.L.154.230；1.L.154.231；1.L.154.236；1.L.154.237；1.L.154.238；1.L.154.239；1.L.154.154；1.L.154.157；1.L.154.166；1.L.154.169；1.L.154.172；1.L.154.175；1.L.154.240；1.L.154.244；1.L.157.228；1.L.157.229；1.L.157.230；1.L.157.231；1.L.157.236；1.L.157.237；1.L.157.238；1.L.157.239；1.L.157.154；1.L.157.157；1.L.157.166；1.L.157.169；1.L.157.172；1.L.157.175；1.L.157.240；1.L.157.244；1.L.166.228；1.L.166.229；1.L.166.230；1.L.166.231；1.L.166.236；1.L.166.237；1.L.166.238；1.L.166.239；1.L.166.154；1.L.166.157；1.L.166.166；1.L.166.169；1.L.166.172；1.L.166.175；1.L.166.240；1.L.166.244；1.L.169.228；1.L.169.229；1.L.169.230；1.L.169.231；1.L.169.236；1.L.169.237；1.L.169.238；1.L.169.239；1.L.169.154；1.L.169.157；1.L.169.166；1.L.169.169；1.L.169.172；1.L.169.175；1.L.169.240；1.L.169.244；1.L.172.228；1.L.172.229；1.L.172.230；1.L.172.231；1.L.172.236；1.L.172.237；1.L.172.238；1.L.172.239；1.L.172.154；1.L.172.157；1.L.172.166；1.L.172.169；1.L.172.172；1.L.172.175；1.L.172.240；1.L.172.244；1.L.175.228；1.L.175.229；1.L.175.230；1.L.175.231；1.L.175.236；1.L.175.237；1.L.175.238；1.L.175.239；1.L.175.154；1.L.175.157；1.L.175.166；1.L.175.169；1.L.175.172；1.L.175.175；1.L.175.240；1.L.175.244；1.L.240.228；1.L.240.229；1.L.240.230；1.L.240.231；1.L.240.236；1.L.240.237；1.L.240.238；1.L.240.239；1.L.240.154；1.L.240.157；1.L.240.166；1.L.240.169；1.L.240.172；1.L.240.175；1.L.240.240；1.L.240.244；1.L.244.228；1.L.244.229；1.L.244.230；1.L.244.231；1.L.244.236；1.L.244.237；1.L.244.238；1.L.244.239；1.L.244.154；1.L.244.157；1.L.244.166；1.L.244.169；1.L.244.172；1.L.244.175；1.L.244.240；1.L.244.244；1.O的前體藥物1.O.228.228；1.O.228.229；1.O.228.230；1.O.228.231；1.O.228.236；1.O.228.237；1.O.228.238；1.O.228.239；1.O.228.154；1.O.228.157；1.O.228.166；1.O.228.169；1.O.228.172；1.O.228.175；1.O.228.240；1.O.228.244；1.O.229.228；1.O.229.229；1.O.229.230；1.O.229.231；1.O.229.236；1.O.229.237；1.O.229.238；1.O.229.239；1.O.229.154；1.O.229.157；1.O.229.166；1.O.229.169；1.O.229.172；1.O.229.175；1.O.229.240；1.O.229.244；1.O.230.228；1.O.230.229；1.O.230.230；1.O.230.231；1.O.230.236；1.O.230.237；1.O.230.238；1.O.230.239；1.O.230.154；1.O.230.157；1.O.230.166；1.O.230.169；1.O.230.172；1.O.230.175；1.O.230.240；1.O.230.244；1.O.231.228；1.O.231.229；1.O.231.230；1.O.231.231；1.O.231.236；1.O.231.237；1.O.231.238；1.O.231.239；1.O.231.154；1.O.231.157；1.O.231.166；1.O.231.169；1.O.231.172；1.O.231.175；1.O.231.240；1.O.231.244；1.O.236.228；1.O.236.229；
1.O.236.230；1.O.236.231；1.O.236.236；1.O.236.237；1.O.236.238；1.O.236.239；1.O.236.154；1.O.236.157；1.O.236.166；1.O.236.169；1.O.236.172；1.O.236.175；1.O.236.240；1.O.236.244；1.O.237.228；1.O.237.229；1.O.237.230；1.O.237.231；1.O.237.236；1.O.237.237；1.O.237.238；1.O.237.239；1.O.237.154；1.O.237.157；1.O.237.166；1.O.237.169；1.O.237.172；1.O.237.175；1.O.237.240；1.O.237.244；1.O.238.228；1.O.238.229；1.O.238.230；1.O.238.231；1.O.238.236；1.O.238.237；1.O.238.238；1.O.238.239；1.O.238.154；1.O.238.157；1.O.238.166；1.O.238.169；1.O.238.172；1.O.238.175；1.O.238.240；1.O.238.244；1.O.239.228；1.O.239.229；1.O.239.230；1.O.239.231；1.O.239.236；1.O.239.237；1.O.239.238；1.O.239.239；1.O.239.154；1.O.239.157；1.O.239.166；1.O.239.169；1.O.239.172；1.O.239.175；1.O.239.240；1.O.239.244；1.O.154.228；1.O.154.229；1.O.154.230；1.O.154.231；1.O.154.236；1.O.154.237；1.O.154.238；1.O.154.239；1.O.154.154；1.O.154.157；1.O.154.166；1.O.154.169；1.O.154.172；1.O.154.175；1.O.154.240；1.O.154.244；1.O.157.228；1.O.157.229；1.O.157.230；1.O.157.231；1.O.157.236；1.O.157.237；1.O.157.238；1.O.157.239；1.O.157.154；1.O.157.157；1.O.157.166；1.O.157.169；1.O.157.172；1.O.157.175；1.O.157.240；1.O.157.244；1.O.166.228；1.O.166.229；1.O.166.230；1.O.166.231；1.O.166.236；1.O.166.237；1.O.166.238；1.O.166.239；1.O.166.154；1.O.166.157；1.O.166.166；1.O.166.169；1.O.166.172；1.O.166.175；1.O.166.240；1.O.166.244；1.O.169.228；1.O.169.229；1.O.169.230；1.O.169.231；1.O.169.236；1.O.169.237；1.O.169.238；1.O.169.239；1.O.169.154；1.O.169.157；1.O.169.166；1.O.169.169；1.O.169.172；1.O.169.175；1.O.169.240；1.O.169.244；1.O.172.228；1.O.172.229；1.O.172.230；1.O.172.231；1.O.172.236；1.O.172.237；1.O.172.238；1.O.172.239；1.O.172.154；1.O.172.157；1.O.172.166；1.O.172.169；1.O.172.172；1.O.172.175；1.O.172.240；1.O.172.244；1.O.175.228；1.O.175.229；1.O.175.230；1.O.175.231；1.O.175.236；1.O.175.237；1.O.175.238；1.O.175.239；1.O.175.154；1.O.175.157；1.O.175.166；1.O.175.169；1.O.175.172；1.O.175.175；1.O.175.240；1.O.175.244；1.O.240.228；1.O.240.229；1.O.240.230；1.O.240.231；1.O.240.236；1.O.240.237；1.O.240.238；1.O.240.239；1.O.240.154；1.O.240.157；1.O.240.166；1.O.240.169；1.O.240.172；1.O.240.175；1.O.240.240；1.O.240.244；1.O.244.228；1.O.244.229；1.O.244.230；1.O.244.231；1.O.244.236；1.O.244.237；1.O.244.238；1.O.244.239；1.O.244.154；1.O.244.157；1.O.244.166；1.O.244.169；1.O.244.172；1.O.244.175；1.O.244.240；1.O.244.244；1.P的前體藥物1.P.228.228；1.P.228.229；1.P.228.230；1.P.228.231；1.P.228.236；1.P.228.237；1.P.228.238；1.P.228.239；1.P.228.154；1.P.228.157；1.P.228.166；1.P.228.169；1.P.228.172；1.P.228.175；1.P.228.240；1.P.228.244；1.P.229.228；1.P.229.229；1.P.229.230；1.P.229.231；1.P.229.236；1.P.229.237；1.P.229.238；1.P.229.239；1.P.229.154；1.P.229.157；1.P.229.166；1.P.229.169；1.P.229.172；1.P.229.175；1.P.229.240；1.P.229.244；1.P.230.228；1.P.230.229；1.P.230.230；1.P.230.231；1.P.230.236；1.P.230.237；1.P.230.238；1.P.230.239；1.P.230.154；1.P.230.157；1.P.230.166；1.P.230.169；1.P.230.172；1.P.230.175；1.P.230.240；1.P.230.244；1.P.231.228；1.P.231.229；1.P.231.230；1.P.231.231；1.P.231.236；1.P.231.237；1.P.231.238；1.P.231.239；1.P.231.154；1.P.231.157；1.P.231.166；1.P.231.169；1.P.231.172；1.P.231.175；1.P.231.240；1.P.231.244；1.P.236.228；1.P.236.229；1.P.236.230；1.P.236.231；1.P.236.236；1.P.236.237；1.P.236.238；1.P.236.239；1.P.236.154；1.P.236.157；1.P.236.166；1.P.236.169；1.P.236.172；1.P.236.175；1.P.236.240；1.P.236.244；1.P.237.228；1.P.237.229；1.P.237.230；
1.P.237.231；1.P.237.236；1.P.237.237；1.P.237.238；1.P.237.239；1.P.237.154；1.P.237.157；1.P.237.166；1.P.237.169；1.P.237.172；1.P.237.175；1.P.237.240；1.P.237.244；1.P.238.228；1.P.238.229；1.P.238.230；1.P.238.231；1.P.238.236；1.P.238.237；1.P.238.238；1.P.238.239；1.P.238.154；1.P.238.157；1.P.238.166；1.P.238.169；1.P.238.172；1.P.238.175；1.P.238.240；1.P.238.244；1.P.239.228；1.P.239.229；1.P.239.230；1.P.239.231；1.P.239.236；1.P.239.237；1.P.239.238；1.P.239.239；1.P.239.154；1.P.239.157；1.P.239.166；1.P.239.169；1.P.239.172；1.P.239.175；1.P.239.240；1.P.239.244；1.P.154.228；1.P.154.229；1.P.154.230；1.P.154.231；1.P.154.236；1.P.154.237；1.P.154.238；1.P.154.239；1.P.154.154；1.P.154.157；1.P.154.166；1.P.154.169；1.P.154.172；1.P.154.175；1.P.154.240；1.P.154.244；1.P.157.228；1.P.157.229；1.P.157.230；1.P.157.231；1.P.157.236；1.P.157.237；1.P.157.238；1.P.157.239；1.P.157.154；1.P.157.157；1.P.157.166；1.P.157.169；1.P.157.172；1.P.157.175；1.P.157.240；1.P.157.244；1.P.166.228；1.P.166.229；1.P.166.230；1.P.166.231；1.P.166.236；1.P.166.237；1.P.166.238；1.P.166.239；1.P.166.154；1.P.166.157；1.P.166.166；1.P.166.169；1.P.166.172；1.P.166.175；1.P.166.240；1.P.166.244；1.P.169.228；1.P.169.229；1.P.169.230；1.P.169.231；1.P.169.236；1.P.169.237；1.P.169.238；1.P.169.239；1.P.169.154；1.P.169.157；1.P.169.166；1.P.169.169；1.P.169.172；1.P.169.175；1.P.169.240；1.P.169.244；1.P.172.228；1.P.172.229；1.P.172.230；1.P.172.231；1.P.172.236；1.P.172.237；1.P.172.238；1.P.172.239；1.P.172.154；1.P.172.157；1.P.172.166；1.P.172.169；1.P.172.172；1.P.172.175；1.P.172.240；1.P.172.244；1.P.175.228；1.P.175.229；1.P.175.230；1.P.175.231；1.P.175.236；1.P.175.237；1.P.175.238；1.P.175.239；1.P.175.154；1.P.175.157；1.P.175.166；1.P.175.169；1.P.175.172；1.P.175.175；1.P.175.240；1.P.175.244；1.P.240.228；1.P.240.229；1.P.240.230；1.P.240.231；1.P.240.236；1.P.240.237；1.P.240.238；1.P.240.239；1.P.240.154；1.P.240.157；1.P.240.166；1.P.240.169；1.P.240.172；1.P.240.175；1.P.240.240；1.P.240.244；1.P.244.228；1.P.244.229；1.P.244.230；1.P.244.231；1.P.244.236；1.P.244.237；1.P.244.238；1.P.244.239；1.P.244.154；1.P.244.157；1.P.244.166；1.P.244.169；1.P.244.172；1.P.244.175；1.P.244.240；1.P.244.244；1.U的前體藥物1.U.228.228；1.U.228.229；1.U.228.230；1.U.228.231；1.U.228.236；1.U.22.8.237；1.U.228.238；1.U.228.239；1.U.228.154；1.U.228.157；1.U.228.166；1.U.228.169；1.U.228.172；1.U.228.175；1.U.228.240；1.U.228.244；1.U.229.228；1.U.229.229；1.U.229.230；1.U.229.231；1.U.229.236；1.U.229.237；1.U.229.238；1.U.229.239；1.U.229.154；1.U.229.157；1.U.229.166；1.U.229.169；1.U.229.172；1.U.229.175；1.U.229.240；1.U.229.244；1.U.230.228；1.U.230.229；1.U.230.230；1.U.230.231；1.U.230.236；1.U.230.237；1.U.230.238；1.U.230.239；1.U.230.154；1.U.230.157；1.U.230.166；1.U.230.169；1.U.230.172；1.U.230.175；1.U.230.240；1.U.230.244；1.U.231.228；1.U.231.229；1.U.231.230；1.U.231.231；1.U.231.236；1.U.231.237；1.U.231.238；1.U.231.239；1.U.231.154；1.U.231.157；1.U.231.166；1.U.231.169；1.U.231.172；1.U.231.175；1.U.231.240；1.U.231.244；1.U.236.228；1.U.236.229；1.U.236.230；1.U.236.231；1.U.236.236；1.U.236.237；1.U.236.238；1.U.236.239；1.U.236.154；1.U.236.157；1.U.236.166；1.U.236.169；1.U.236.172；1.U.236.175；1.U.236.240；1.U.236.244；1.U.237.228；1.U.237.229；1.U.237.230；1.U.237.231；1.U.237.236；1.U.237.237；1.U.237.238；1.U.237.239；1.U.237.154；1.U.237.157；1.U.237.166；1.U.237.169；1.U.237.172；1.U.237.175；1.U.237.240；1.U.237.244；1.U.238.228；1.U.238.229；1.U.238.230；1.U.238.231；1.U.238.236；1.U.238.237；1.U.238.238；1.U.238.239；1.U.238.154；1.U.238.157；1.U.238.166；1.U.238.169；1.U.238.172；1.U.238.175；1.U.238.240；1.U.238.244；1.U.239.228；1.U.239.229；
1.U.239.230；1.U.239.231；1.U.239.236；1.U.239.237；1.U.239.238；1.U.239.239；1.U.239.154；1.U.239.157；1.U.239.166；1.U.239.169；1.U.239.172；1.U.239.175；1.U.239.240；1.U.239.244；1.U.154.228；1.U.154.229；1.U.154.230；1.U.154.231；1.U.154.236；1.U.154.237；1.U.154.238；1.U.154.239；1.U.154.154；1.U.154.157；1.U.154.166；1.U.154.169；1.U.154.172；1.U.154.175；1.U.154.240；1.U.154.244；1.U.157.228；1.U.157.229；1.U.157.230；1.U.157.231；1.U.157.236；1.U.157.237；1.U.157.238；1.U.157.239；1.U.157.154；1.U.157.157；1.U.157.166；1.U.157.169；1.U.157.172；1.U.157.175；1.U.157.240；1.U.157.244；1.U.166.228；1.U.166.229；1.U.166.230；1.U.166.231；1.U.166.236；1.U.166.237；1.U.166.238；1.U.166.239；1.U.166.154；1.U.166.157；1.U.166.166；1.U.166.169；1.U.166.172；1.U.166.175；1.U.166.240；1.U.166.244；1.U.169.228；1.U.169.229；1.U.169.230；1.U.169.231；1.U.169.236；1.U.169.237；1.U.169.238；1.U.169.239；1.U.169.154；1.U.169.157；1.U.169.166；1.U.169.169；1.U.169.172；1.U.169.175；1.U.169.240；1.U.169.244；1.U.172.228；1.U.172.229；1.U.172.230；1.U.172.231；1.U.172.236；1.U.172.237；1.U.172.238；1.U.172.239；1.U.172.154；1.U.172.157；1.U.172.166；1.U.172.169；1.U.172.172；1.U.172.175；1.U.172.240；1.U.172.244；1.U.175.228；1.U.175.229；1.U.175.230；1.U.175.231；1.U.175.236；1.U.175.237；1.U.175.238；1.U.175.239；1.U.175.154；1.U.175.157；1.U.175.166；1.U.175.169；1.U.175.172；1.U.175.175；1.U.175.240；1.U.175.244；1.U.240.228；1.U.240.229；1.U.240.230；1.U.240.231；1.U.240.236；1.U.240.237；1.U.240.238；1.U.240.239；1.U.240.154；1.U.240.157；1.U.240.166；1.U.240.169；1.U.240.172；1.U.240.175；1.U.240.240；1.U.240.244；1.U.244.228；1.U.244.229；1.U.244.230；1.U.244.231；1.U.244.236；1.U.244.237；1.U.244.238；1.U.244.239；1.U.244.154；1.U.244.157；1.U.244.166；1.U.244.169；1.U.244.172；1.U.244.175；1.U.244.240；1.U.244.244；1.W的前體藥物1.W.228.228；1.W.228.229；1.W.228.230；1.W.228.231；1.W.228.236；1.W.228.237；1.W.228.238；1.W.228.239；1.W.228.154；1.W.228.157；1.W.228.166；1.W.228.169；1.W.228.172；1.W.228.175；1.W.228.240；1.W.228.244；1.W.229.228；1.W.229.229；1.W.229.230；1.W.229.231；1.W.229.236；1.W.229.237；1.W.229.238；1.W.229.239；1.W.229.154；1.W.229.157；1.W.229.166；1.W.229.169；1.W.229.172；1.W.229.175；1.W.229.240；1.W.229.244；1.W.230.228；1.W.230.229；1.W.230.230；1.W.230.231；1.W.230.236；1.W.230.237；1.W.230.238；1.W.230.239；1.W.230.154；1.W.230.157；1.W.230.166；1.W.230.169；1.W.230.172；1.W.230.175；1.W.230.240；1.W.230.244；1.W.231.228；1.W.231.229；1.W.231.230；1.W.231.231；1.W.231.236；1.W.231.237；1.W.231.238；1.W.231.239；1.W.231.154；1.W.231.157；1.W.231.166；1.W.231.169；1.W.231.172；1.W.231.175；1.W.231.240；1.W.231.244；1.W.236.228；1.W.236.229；1.W.236.230；1.W.236.231；1.W.236.236；1.W.236.237；1.W.236.238；1.W.236.239；1.W.236.154；1.W.236.157；1.W.236.166；1.W.236.169；1.W.236.172；1.W.236.175；1.W.236.240；1.W.236.244；1.W.237.228；1.W.237.229；1.W.237.230；1.W.237.231；1.W.237.236；1.W.237.237；1.W.237.238；1.W.237.239；1.W.237.154；1.W.237.157；1.W.237.166；1.W.237.169；1.W.237.172；1.W.237.175；1.W.237.240；1.W.237.244；1.W.238.228；1.W.238.229；1.W.238.230；1.W.238.231；1.W.238.236；1.W.238.237；1.W.238.238；1.W.238.239；1.W.238.154；1.W.238.157；1.W.238.166；1.W.238.169；1.W.238.172；1.W.238.175；1.W.238.240；1.W.238.244；1.W.239.228；1.W.239.229；1.W.239.230；1.W.239.231；1.W.239.236；1.W.239.237；1.W.239.238；1.W.239.239；
1.W.239.154；1.W.239.157；1.W.239.166；1.W.239.169；1.W.239.172；1.W.239.175；1.W.239.240；1.W.239.244；1.W.154.228；1.W.154.229；1.W.154.230；1.W.154.231；1.W.154.236；1.W.154.237；1.W.154.238；1.W.154.239；1.W.154.154；1.W.154.157；1.W.154.166；1.W.154.169；1.W.154.172；1.W.154.175；1.W.154.240；1.W.154.244；1.W.157.228；1.W.157.229；1.W.157.230；1.W.157.231；1.W.157.236；1.W.157.237；1.W.157.238；1.W.157.239；1.W.157.154；1.W.157.157；1.W.157.166；1.W.157.169；1.W.157.172；1.W.157.175；1.W.157.240；1.W.157.244；1.W.166.228；1.W.166.229；1.W.166.230；1.W.166.231；1.W.166.236；1.W.166.237；1.W.166.238；1.W.166.239；1.W.166.154；1.W.166.157；1.W.166.166；1.W.166.169；1.W.166.172；1.W.166.175；1.W.166.240；1.W.166.244；1.W.169.228；1.W.169.229；1.W.169.230；1.W.169.231；1.W.169.236；1.W.169.237；1.W.169.238；1.W.169.239；1.W.169.154；1.W.169.157；1.W.169.166；1.W.169.169；1.W.169.172；1.W.169.175；1.W.169.240；1.W.169.244；1.W.172.228；1.W.172.229；1.W.172.230；1.W.172.231；1.W.172.236；1.W.172.237；1.W.172.238；1.W.172.239；1.W.172.154；1.W.172.157；1.W.172.166；1.W.172.169；1.W.172.172；1.W.172.175；1.W.172.240；1.W.172.244；1.W.175.228；1.W.175.229；1.W.175.230；1.W.175.231；1.W.175.236；1.W.175.237；1.W.175.238；1.W.175.239；1.W.175.154；1.W.175.157；1.W.175.166；1.W.175.169；1.W.175.172；1.W.175.175；1.W.175.240；1.W.175.244；1.W.240.228；1.W.240.229；1.W.240.230；1.W.240.231；1.W.240.236；1.W.240.237；1.W.240.238；1.W.240.239；1.W.240.154；1.W.240.157；1.W.240.166；1.W.240.169；1.W.240.172；1.W.240.175；1.W.240.240；1.W.240.244；1.W.244.228；1.W.244.229；1.W.244.230；1.W.244.231；1.W.244.236；1.W.244.237；1.W.244.238；1.W.244.239；1.W.244.154；1.W.244.157；1.W.244.166；1.W.244.169；1.W.244.172；1.W.244.175；1.W.244.240；1.W.244.244；1.Y的前體藥物1.Y.228.228；1.Y.228.229；1.Y.228.230；1.Y.228.231；1.Y.228.236；1.Y.228.237；1.Y.228.238；1.Y.228.239；1.Y.228.154；1.Y.228.157；1.Y.228.166；1.Y.228.169；1.Y.228.172；1.Y.228.175；1.Y.228.240；1.Y.228.244；1.Y.229.228；1.Y.229.229；1.Y.229.230；1.Y.229.231；1.Y.229.236；1.Y.229.237；1.Y.229.238；1.Y.229.239；1.Y.229.154；1.Y.229.157；1.Y.229.166；1.Y.229.169；1.Y.229.172；1.Y.229.175；1.Y.229.240；1.Y.229.244；1.Y.230.228；1.Y.230.229；1.Y.230.230；1.Y.230.231；1.Y.230.236；1.Y.230.237；1.Y.230.238；1.Y.230.239；1.Y.230.154；1.Y.230.157；1.Y.230.166；1.Y.230.169；1.Y.230.172；1.Y.230.175；1.Y.230.240；1.Y.230.244；1.Y.231.228；1.Y.231.229；1.Y.231.230；1.Y.231.231；1.Y.231.236；1.Y.231.237；1.Y.231.238；1.Y.231.239；1.Y.231.154；1.Y.231.157；1.Y.231.166；1.Y.231.169；1.Y.231.172；1.Y.231.175；1.Y.231.240；1.Y.231.244；1.Y.236.228；1.Y.236.229；1.Y.236.230；1.Y.236.231；1.Y.236.236；1.Y.236.237；1.Y.236.238；1.Y.236.239；1.Y.236.154；1.Y.236.157；1.Y.236.166；1.Y.236.169；1.Y.236.172；1.Y.236.175；1.Y.236.240；1.Y.236.244；1.Y.237.228；1.Y.237.229；1.Y.237.230；1.Y.237.231；1.Y.237.236；1.Y.237.237；1.Y.237.238；1.Y.237.239；1.Y.237.154；1.Y.237.157；1.Y.237.166；1.Y.237.169；1.Y.237.172；1.Y.237.175；1.Y.237.240；1.Y.237.244；1.Y.238.228；1.Y.238.229；1.Y.238.230；1.Y.238.231；1.Y.238.236；1.Y.238.237；1.Y.238.238；1.Y.238.239；1.Y.238.154；1.Y.238.157；1.Y.238.166；1.Y.238.169；1.Y.238.172；1.Y.238.175；1.Y.238.240；1.Y.238.244；1.Y.239.228；1.Y.239.229；1.Y.239.230；1.Y.239.231；1.Y.239.236；1.Y.239.237；1.Y.239.238；1.Y.239.239；1.Y.239.154；1.Y.239.157；1.Y.239.166；1.Y.239.169；1.Y.239.172；1.Y.239.175；
1.Y.239.240；1.Y.239.244；1.Y.154.228；1.Y.154.229；1.Y.154.230；1.Y.154.231；1.Y.154.236；1.Y.154.237；1.Y.154.238；1.Y.154.239；1.Y.154.154；1.Y.154.157；1.Y.154.166；1.Y.154.169；1.Y.154.172；1.Y.154.175；1.Y.154.240；1.Y.154.244；1.Y.157.228；1.Y.157.229；1.Y.157.230；1.Y.157.231；1.Y.157.236；1.Y.157.237；1.Y.157.238；1.Y.157.239；1.Y.157.154；1.Y.157.157；1.Y.157.166；1.Y.157.169；1.Y.157.172；1.Y.157.175；1.Y.157.240；1.Y.157.244；1.Y.166.228；1.Y.166.229；1.Y.166.230；1.Y.166.231；1.Y.166.236；1.Y.166.237；1.Y.166.238；1.Y.166.239；1.Y.166.154；1.Y.166.157；1.Y.166.166；1.Y.166.169；1.Y.166.172；1.Y.166.175；1.Y.166.240；1.Y.166.244；1.Y.169.228；1.Y.169.229；1.Y.169.230；1.Y.169.231；1.Y.169.236；1.Y.169.237；1.Y.169.238；1.Y.169.239；1.Y.169.154；1.Y.169.157；1.Y.169.166；1.Y.169.169；1.Y.169.172；1.Y.169.175；1.Y.169.240；1.Y.169.244；1.Y.172.228；1.Y.172.229；1.Y.172.230；1.Y.172.231；1.Y.172.236；1.Y.172.237；1.Y.172.238；1.Y.172.239；1.Y.172.154；1.Y.172.157；1.Y.172.166；1.Y.172.169；1.Y.172.172；1.Y.172.175；1.Y.172.240；1.Y.172.244；1.Y.175.228；1.Y.175.229；1.Y.175.230；1.Y.175.231；1.Y.175.236；1.Y.175.237；1.Y.175.238；1.Y.175.239；1.Y.175.154；1.Y.175.157；1.Y.175.166；1.Y.175.169；1.Y.175.172；1.Y.175.175；1.Y.175.240；1.Y.175.244；1.Y.240.228；1.Y.240.229；1.Y.240.230；1.Y.240.231；1.Y.240.236；1.Y.240.237；1.Y.240.238；1.Y.240.239；1.Y.240.154；1.Y.240.157；1.Y.240.166；1.Y.240.169；1.Y.240.172；1.Y.240.175；1.Y.240.240；1.Y.240.244；1.Y.244.228；1.Y.244.229；1.Y.244.230；1.Y.244.231；1.Y.244.236；1.Y.244.237；1.Y.244.238；1.Y.244.239；1.Y.244.154；1.Y.244.157；1.Y.244.166；1.Y.244.169；1.Y.244.172；1.Y.244.175；1.Y.244.240；1.Y.244.244；2.B的前體藥物2.B.228.228；2.B.228.229；2.B.228.230；2.B.228.231；2.B.228.236；2.B.228.237；2.B.228.238；2.B.228.239；2.B.228.154；2.B.228.157；2.B.228.166；2.B.228.169；2.B.228.172；2.B.228.175；2.B.228.240；2.B.228.244；2.B.229.228；2.B.229.229；2.B.229.230；2.B.229.231；2.B.229.236；2.B.229.237；2.B.229.238；2.B.229.239；2.B.229.154；2.B.229.157；2.B.229.166；2.B.229.169；2.B.229.172；2.B.229.175；2.B.229.240；2.B.229.244；2.B.230.228；2.B.230.229；2.B.230.230；2.B.230.231；2.B.230.236；2.B.230.237；2.B.230.238；2.B.230.239；2.B.230.154；2.B.230.157；2.B.230.166；2.B.230.169；2.B.230.172；2.B.230.175；2.B.230.240；2.B.230.244；2.B.231.228；2.B.231.229；2.B.231.230；2.B.231.231；2.B.231.236；2.B.231.237；2.B.231.238；2.B.231.239；2.B.231.154；2.B.231.157；2.B.231.166；2.B.231.169；2.B.231.172；2.B.231.175；2.B.231.240；2.B.231.244；2.B.236.228；2.B.236.229；2.B.236.230；2.B.236.231；2.B.236.236；2.B.236.237；2.B.236.238；2.B.236.239；2.B.236.154；2.B.236.157；2.B.236.166；2.B.236.169；2.B.236.172；2.B.236.175；2.B.236.240；2.B.236.244；2.B.237.228；2.B.237.229；2.B.237.230；2.B.237.231；2.B.237.236；2.B.237.237；2.B.237.238；2.B.237.239；2.B.237.154；2.B.237.157；2.B.237.166；2.B.237.169；2.B.237.172；2.B.237.175；2.B.237.240；2.B.237.244；2.B.238.228；2.B.238.229；2.B.238.230；2.B.238.231；2.B.238.236；2.B.238.237；2.B.238.238；2.B.238.239；2.B.238.154；2.B.238.157；2.B.238.166；2.B.238.169；2.B.238.172；2.B.238.175；2.B.238.240；2.B.238.244；2.B.239.228；2.B.239.229；2.B.239.230；2.B.239.231；2.B.239.236；2.B.239.237；2.B.239.238；2.B.239.239；2.B.239.154；2.B.239.157；2.B.239.166；2.B.239.169；2.B.239.172；2.B.239.175；2.B.239.240；2.B.239.244；2.B.154.228；2.B.154.229；2.B.154.230；2.B.154.231；
2.B.154.236；2.B.154.237；2.B.154.238；2.B.154.239；2.B.154.154；2.B.154.157；2.B.154.166；2.B.154.169；2.B.154.172；2.B.154.175；2.B.154.240；2.B.154.244；2.B.157.228；2.B.157.229；2.B.157.230；2.B.157.231；2.B.157.236；2.B.157.237；2.B.157.238；2.B.157.239；2.B.157.154；2.B.157.157；2.B.157.166；2.B.157.169；2.B.157.172；2.B.157.175；2.B.157.240；2.B.157.244；2.B.166.228；2.B.166.229；2.B.166.230；2.B.166.231；2.B.166.236；2.B.166.237；2.B.166.238；2.B.166.239；2.B.166.154；2.B.166.157；2.B.166.166；2.B.166.169；2.B.166.172；2.B.166.175；2.B.166.240；2.B.166.244；2.B.169.228；2.B.169.229；2.B.169.230；2.B.169.231；2.B.169.236；2.B.169.237；2.B.169.238；2.B.169.239；2.B.169.154；2.B.169.157；2.B.169.166；2.B.169.169；2.B.169.172；2.B.169.175；2.B.169.240；2.B.169.244；2.B.172.228；2.B.172.229；2.B.172.230；2.B.172.231；2.B.172.236；2.B.172.237；2.B.172.238；2.B.172.239；2.B.172.154；2.B.172.157；2.B.172.166；2.B.172.169；2.B.172.172；2.B.172.175；2.B.172.240；2.B.172.244；2.B.175.228；2.B.175.229；2.B.175.230；2.B.175.231；2.B.175.236；2.B.175.237；2.B.175.238；2.B.175.239；2.B.175.154；2.B.175.157；2.B.175.166；2.B.175.169；2.B.175.172；2.B.175.175；2.B.175.240；2.B.175.244；2.B.240.228；2.B.240.229；2.B.240.230；2.B.240.231；2.B.240.236；2.B.240.237；2.B.240.238；2.B.240.239；2.B.240.154；2.B.240.157；2.B.240.166；2.B.240.169；2.B.240.172；2.B.240.175；2.B.240.240；2.B.240.244；2.B.244.228；2.B.244.229；2.B.244.230；2.B.244.231；2.B.244.236；2.B.244.237；2.B.244.238；2.B.244.239；2.B.244.154；2.B.244.157；2.B.244.166；2.B.244.169；2.B.244.172；2.B.244.175；2.B.244.240；2.B.244.244；2.D的前體藥物2.D.228.228；2.D.228.229；2.D.228.230；2.D.228.231；2.D.228.236；2.D.228.237；2.D.228.238；2.D.228.239；2.D.228.154；2.D.228.157；2.D.228.166；2.D.228.169；2.D.228.172；2.D.228.175；2.D.228.240；2.D.228.244；2.D.229.228；2.D.229.229；2.D.229.230；2.D.229.231；2.D.229.236；2.D.229.237；2.D.229.238；2.D.229.239；2.D.229.154；2.D.229.157；2.D.229.166；2.D.229.169；2.D.229.172；2.D.229.175；2.D.229.240；2.D.229.244；2.D.230.228；2.D.230.229；2.D.230.230；2.D.230.231；2.D.230.236；2.D.230.237；2.D.230.238；2.D.230.239；2.D.230.154；2.D.230.157；2.D.230.166；2.D.230.169；2.D.230.172；2.D.230.175；2.D.230.240；2.D.230.244；2.D.231.228；2.D.231.229；2.D.231.230；2.D.231.231；2.D.231.236；2.D.231.237；2.D.231.238；2.D.231.239；2.D.231.154；2.D.231.157；2.D.231.166；2.D.231.169；2.D.231.172；2.D.231.175；2.D.231.240；2.D.231.244；2.D.236.228；2.D.236.229；2.D.236.230；2.D.236.231；2.D.236.236；2.D.236.237；2.D.236.238；2.D.236.239；2.D.236.154；2.D.236.157；2.D.236.166；2.D.236.169；2.D.236.172；2.D.236.175；2.D.236.240；2.D.236.244；2.D.237.228；2.D.237.229；2.D.237.230；2.D.237.231；2.D.237.236；2.D.237.237；2.D.237.238；2.D.237.239；2.D.237.154；2.D.237.157；2.D.237.166；2.D.237.169；2.D.237.172；2.D.237.175；2.D.237.240；2.D.237.244；2.D.238.228；2.D.238.229；2.D.238.230；2.D.238.231；2.D.238.236；2.D.238.237；2.D.238.238；2.D.238.239；2.D.238.154；2.D.238.157；2.D.238.166；2.D.238.169；2.D.238.172；2.D.238.175；2.D.238.240；2.D.238.244；2.D.239.228；2.D.239.229；2.D.239.230；2.D.239.231；2.D.239.236；2.D.239.237；2.D.239.238；2.D.239.239；2.D.239.154；2.D.239.157；2.D.239.166；2.D.239.169；2.D.239.172；2.D.239.175；2.D.239.240；2.D.239.244；2.D.154.228；2.D.154.229；2.D.154.230；2.D.154.231；2.D.154.236；2.D.154.237；2.D.154.238；2.D.154.239；2.D.154.154；2.D.154.157；
2.D.154.166；2.D.154.169；2.D.154.172；2.D.154.175；2.D.154.240；2.D.154.244；2.D.157.228；2.D.157.229；2.D.157.230；2.D.157.231；2.D.157.236；2.D.157.237；2.D.157.238；2.D.157.239；2.D.157.154；2.D.157.157；2.D.157.166；2.D.157.169；2.D.157.172；2.D.157.175；2.D.157.240；2.D.157.244；2.D.166.228；2.D.166.229；2.D.166.230；2.D.166.231；2.D.166.236；2.D.166.237；2.D.166.238；2.D.166.239；2.D.166.154；2.D.166.157；2.D.166.166；2.D.166.169；2.D.166.172；2.D.166.175；2.D.166.240；2.D.166.244；2.D.169.228；2.D.169.229；2.D.169.230；2.D.169.231；2.D.169.236；2.D.169.237；2.D.169.238；2.D.169.239；2.D.169.154；2.D.169.157；2.D.169.166；2.D.169.169；2.D.169.172；2.D.169.175；2.D.169.240；2.D.169.244；2.D.172.228；2.D.172.229；2.D.172.230；2.D.172.231；2.D.172.236；2.D.172.237；2.D.172.238；2.D.172.239；2.D.172.154；2.D.172.157；2.D.172.166；2.D.172.169；2.D.172.172；2.D.172.175；2.D.172.240；2.D.172.244；2.D.175.228；2.D.175.229；2.D.175.230；2.D.175.231；2.D.175.236；2.D.175.237；2.D.175.238；2.D.175.239；2.D.175.154；2.D.175.157；2.D.175.166；2.D.175.169；2.D.175.172；2.D.175.175；2.D.175.240；2.D.175.244；2.D.240.228；2.D.240.229；2.D.240.230；2.D.240.231；2.D.240.236；2.D.240.237；2.D.240.238；2.D.240.239；2.D.240.154；2.D.240.157；2.D.240.166；2.D.240.169；2.D.240.172；2.D.240.175；2.D.240.240；2.D.240.244；2.D.244.228；2.D.244.229；2.D.244.230；2.D.244.231；2.D.244.236；2.D.244.237；2.D.244.238；2.D.244.239；2.D.244.154；2.D.244.157；2.D.244.166；2.D.244.169；2.D.244.172；2.D.244.175；2.D.244.240；2.D.244.244；2.E的前體藥物2.E.228.228；2.E.228.229；2.E.228.230；2.E.228.231；2.E.228.236；2.E.228.237；2.E.228.238；2.E.228.239；2.E.228.154；2.E.228.157；2.E.228.166；2.E.228.169；2.E.228.172；2.E.228.175；2.E.228.240；2.E.228.244；2.E.229.228；2.E.229.229；2.E.229.230；2.E.229.231；2.E.229.236；2.E.229.237；2.E.229.238；2.E.229.239；2.E.229.154；2.E.229.157；2.E.229.166；2.E.229.169；2.E.229.172；2.E.229.175；2.E.229.240；2.E.229.244；2.E.230.228；2.E.230.229；2.E.230.230；2.E.230.231；2.E.230.236；2.E.230.237；2.E.230.238；2.E.230.239；2.E.230.154；2.E.230.157；2.E.230.166；2.E.230.169；2.E.230.172；2.E.230.175；2.E.230.240；2.E.230.244；2.E.231.228；2.E.231.229；2.E.231.230；2.E.231.231；2.E.231.236；2.E.231.237；2.E.231.238；2.E.231.239；2.E.231.154；2.E.231.157；2.E.231.166；2.E.231.169；2.E.231.172；2.E.231.175；2.E.231.240；2.E.231.244；2.E.236.228；2.E.236.229；2.E.236.230；2.E.236.231；2.E.236.236；2.E.236.237；2.E.236.238；2.E.236.239；2.E.236.154；2.E.236.157；2.E.236.166；2.E.236.169；2.E.236.172；2.E.236.175；2.E.236.240；2.E.236.244；2.E.237.228；2.E.237.229；2.E.237.230；2.E.237.231；2.E.237.236；2.E.237.237；2.E.237.238；2.E.237.239；2.E.237.154；2.E.237.157；2.E.237.166；2.E.237.169；2.E.237.172；2.E.237.175；2.E.237.240；2.E.237.244；2.E.238.228；2.E.238.229；2.E.238.230；2.E.238.231；2.E.238.236；2.E.238.237；2.E.238.238；2.E.238.239；2.E.238.154；2.E.238.157；2.E.238.166；2.E.238.169；2.E.238.172；2.E.238.175；2.E.238.240；2.E.238.244；2.E.239.228；2.E.239.229；2.E.239.230；2.E.239.231；2.E.239.236；2.E.239.237；2.E.239.238；2.E.239.239；2.E.239.154；2.E.239.157；2.E.239.166；2.E.239.169；2.E.239.172；2.E.239.175；2.E.239.240；2.E.239.244；2.E.154.228；2.E.154.229；2.E.154.230；2.E.154.231；2.E.154.236；2.E.154.237；2.E.154.238；2.E.154.239；2.E.154.154；2.E.154.157；2.E.154.166；2.E.154.169；2.E.154.172；2.E.154.175；2.E.154.240；2.E.154.244；
2.E.157.228；2.E.157.229；2.E.157.230；2.E.157.231；2.E.157.236；2.E.157.237；2.E.157.238；2.E.157.239；2.E.157.154；2.E.157.157；2.E.157.166；2.E.157.169；2.E.157.172；2.E.157.175；2.E.157.240；2.E.157.244；2.E.166.228；2.E.166.229；2.E.166.230；2.E.166.231；2.E.166.236；2.E.166.237；2.E.166.238；2.E.166.239；2.E.166.154；2.E.166.157；2.E.166.166；2.E.166.169；2.E.166.172；2.E.166.175；2.E.166.240；2.E.166.244；2.E.169.228；2.E.169.229；2.E.169.230；2.E.169.231；2.E.169.236；2.E.169.237；2.E.169.238；2.E.169.239；2.E.169.154；2.E.169.157；2.E.169.166；2.E.169.169；2.E.169.172；2.E.169.175；2.E.169.240；2.E.169.244；2.E.172.228；2.E.172.229；2.E.172.230；2.E.172.231；2.E.172.236；2.E.172.237；2.E.172.238；2.E.172.239；2.E.172.154；2.E.172.157；2.E.172.166；2.E.172.169；2.E.172.172；2.E.172.175；2.E.172.240；2.E.172.244；2.E.175.228；2.E.175.229；2.E.175.230；2.E.175.231；2.E.175.236；2.E.175.237；2.E.175.238；2.E.175.239；2.E.175.154；2.E.175.157；2.E.175.166；2.E.175.169；2.E.175.172；2.E.175.175；2.E.175.240；2.E.175.244；2.E.240.228；2.E.240.229；2.E.240.230；2.E.240.231；2.E.240.236；2.E.240.237；2.E.240.238；2.E.240.239；2.E.240.154；2.E.240.157；2.E.240.166；2.E.240.169；2.E.240.172；2.E.240.175；2.E.240.240；2.E.240.244；2.E.244.228；2.E.244.229；2.E.244.230；2.E.244.231；2.E.244.236；2.E.244.237；2.E.244.238；2.E.244.239；2.E.244.154；2.E.244.157；2.E.244.166；2.E.244.169；2.E.244.172；2.E.244.175；2.E.244.240；2.E.244.244；2.G的前體藥物2.G.228.228；2.G.228.229；2.G.228.230；2.G.228.231；2.G.228.236；2.G.228.237；2.G.228.238；2.G.228.239；2.G.228.154；2.G.228.157；2.G.228.166；2.G.228.169；2.G.228.172；2.G.228.175；2.G.228.240；2.G.228.244；2.G.229.228；2.G.229.229；2.G.229.230；2.G.229.231；2.G.229.236；2.G.229.237；2.G.229.238；2.G.229.239；2.G.229.154；2.G.229.157；2.G.229.166；2.G.229.169；2.G.229.172；2.G.229.175；2.G.229.240；2.G.229.244；2.G.230.228；2.G.230.229；2.G.230.230；2.G.230.231；2.G.230.236；2.G.230.237；2.G.230.238；2.G.230.239；2.G.230.154；2.G.230.157；2.G.230.166；2.G.230.169；2.G.230.172；2.G.230.175；2.G.230.240；2.G.230.244；2.G.231.228；2.G.231.229；2.G.231.230；2.G.231.231；2.G.231.236；2.G.231.237；2.G.231.238；2.G.231.239；2.G.231.154；2.G.231.157；2.G.231.166；2.G.231.169；2.G.231.172；2.G.231.175；2.G.231.240；2.G.231.244；2.G.236.228；2.G.236.229；2.G.236.230；2.G.236.231；2.G.236.236；2.G.236.237；2.G.236.238；2.G.236.239；2.G.236.154；2.G.236.157；2.G.236.166；2.G.236.169；2.G.236.172；2.G.236.175；2.G.236.240；2.G.236.244；2.G.237.228；2.G.237.229；2.G.237.230；2.G.237.231；2.G.237.236；2.G.237.237；2.G.237.238；2.G.237.239；2.G.237.154；2.G.237.157；2.G.237.166；2.G.237.169；2.G.237.172；2.G.237.175；2.G.237.240；2.G.237.244；2.G.238.228；2.G.238.229；2.G.238.230；2.G.238.231；2.G.238.236；2.G.238.237；2.G.238.238；2.G.238.239；2.G.238.154；2.G.238.157；2.G.238.166；2.G.238.169；2.G.238.172；2.G.238.175；2.G.238.240；2.G.238.244；2.G.239.228；2.G.239.229；2.G.239.230；2.G.239.231；2.G.239.236；2.G.239.237；2.G.239.238；2.G.239.239；2.G.239.154；2.G.239.157；2.G.239.166；2.G.239.169；2.G.239.172；2.G.239.175；2.G.239.240；2.G.239.244；2.G.154.228；2.G.154.229；2.G.154.230；2.G.154.231；2.G.154.236；2.G.154.237；2.G.154.238；2.G.154.239；2.G.154.154；2.G.154.157；2.G.154.166；2.G.154.169；2.G.154.172；2.G.154.175；2.G.154.240；2.G.154.244；2.G.157.228；2.G.157.229；2.G.157.230；2.G.157.231；2.G.157.236；2.G.157.237；
2.G.157.238；2.G.157.239；2.G.157.154；2.G.157.157；2.G.157.166；2.G.157.169；2.G.157.172；2.G.157.175；2.G.157.240；2.G.157.244；2.G.166.228；2.G.166.229；2.G.166.230；2.G.166.231；2.G.166.236；2.G.166.237；2.G.166.238；2.G.166.239；2.G.166.154；2.G.166.157；2.G.166.166；2.G.166.169；2.G.166.172；2.G.166.175；2.G.166.240；2.G.166.244；2.G.169.228；2.G.169.229；2.G.169.230；2.G.169.231；2.G.169.236；2.G.169.237；2.G.169.238；2.G.169.239；2.G.169.154；2.G.169.157；2.G.169.166；2.G.169.169；2.G.169.172；2.G.169.175；2.G.169.240；2.G.169.244；2.G.172.228；2.G.172.229；2.G.172.230；2.G.172.231；2.G.172.236；2.G.172.237；2.G.172.238；2.G.172.239；2.G.172.154；2.G.172.157；2.G.172.166；2.G.172.169；2.G.172.172；2.G.172.175；2.G.172.240；2.G.172.244；2.G.175.228；2.G.175.229；2.G.175.230；2.G.175.231；2.G.175.236；2.G.175.237；2.G.175.238；2.G.175.239；2.G.175.154；2.G.175.157；2.G.175.166；2.G.175.169；2.G.175.172；2.G.175.175；2.G.175.240；2.G.175.244；2.G.240.228；2.G.240.229；2.G.240.230；2.G.240.231；2.G.240.236；2.G.240.237；2.G.240.238；2.G.240.239；2.G.240.154；2.G.240.157；2.G.240.166；2.G.240.169；2.G.240.172；2.G.240.175；2.G.240.240；2.G.240.244；2.G.244.228；2.G.244.229；2.G.244.230；2.G.244.231；2.G.244.236；2.G.244.237；2.G.244.238；2.G.244.239；2.G.244.154；2.G.244.157；2.G.244.166；2.G.244.169；2.G.244.172；2.G.244.175；2.G.244.240；2.G.244.244；2.I的前體藥物2.I.228.228；2.I.228.229；2.I.228.230；2.I.228.231；2.I.228.236；2.I.228.237；2.I.228.238；2.I.228.239；2.I.228.154；2.I.228.157；2.I.228.166；2.I.228.169；2.I.228.172；2.I.228.175；2.I.228.240；2.I.228.244；2.I.229.228；2.I.229.229；2.I.229.230；2.I.229.231；2.I.229.236；2.I.229.237；2.I.229.238；2.I.229.239；2.I.229.154；2.I.229.157；2.I.229.166；2.I.229.169；2.I.229.172；2.I.229.175；2.I.229.240；2.I.229.244；2.I.230.228；2.I.230.229；2.I.230.230；2.I.230.231；2.I.230.236；2.I.230.237；2.I.230.238；2.I.230.239；2.I.230.154；2.I.230.157；2.I.230.166；2.I.230.169；2.I.230.172；2.I.230.175；2.I.230.240；2.I.230.244；2.I.231.228；2.I.231.229；2.I.231.230；2.I.231.231；2.I.231.236；2.I.231.237；2.I.231.238；2.I.231.239；2.I.231.154；2.I.231.157；2.I.231.166；2.I.231.169；2.I.231.172；2.I.231.175；2.I.231.240；2.I.231.244；2.I.236.228；2.I.236.229；2.I.236.230；2.I.236.231；2.I.236.236；2.I.236.237；2.I.236.238；2.I.236.239；2.I.236.154；2.I.236.157；2.I.236.166；2.I.236.169；2.I.236.172；2.I.236.175；2.I.236.240；2.I.236.244；2.I.237.228；2.I.237.229；2.I.237.230；2.I.237.231；2.I.237.236；2.I.237.237；2.I.237.238；2.I.237.239；2.I.237.154；2.I.237.157；2.I.237.166；2.I.237.169；2.I.237.172；2.I.237.175；2.I.237.240；2.I.237.244；2.I.238.228；2.I.238.229；2.I.238.230；2.I.238.231；2.I.238.236；2.I.238.237；2.I.238.238；2.I.238.239；2.I.238.154；2.I.238.157；2.I.238.166；2.I.238.169；2.I.238.172；2.I.238.175；2.I.238.240；2.I.238.244；2.I.239.228；2.I.239.229；2.I.239.230；2.I.239.231；2.I.239.236；2.I.239.237；2.I.239.238；2.I.239.239；2.I.239.154；2.I.239.157；2.I.239.166；2.I.239.169；2.I.239.172；2.I.239.175；2.I.239.240；2.I.239.244；2.I.154.228；2.I.154.229；2.I.154.230；2.I.154.231；2.I.154.236；2.I.154.237；2.I.154.238；2.I.154.239；2.I.154.154；2.I.154.157；2.I.154.166；2.I.154.169；2.I.154.172；2.I.154.175；2.I.154.240；2.I.154.244；2.I.157.228；2.I.157.229；2.I.157.230；2.I.157.231；2.I.157.236；2.I.157.237；2.I.157.238；2.I.157.239；2.I.157.154；2.I.157.157；2.I.157.166；2.I.157.169；2.I.157.172；2.I.157.175；2.I.157.240；2.I.157.244；2.I.166.228；2.I.166.229；2.I.166.230；2.I.166.231；2.I.166.236；2.I.166.237；2.I.166.238；2.I.166.239；2.I.166.154；2.I.166.157；2.I.166.166；2.I.166.169；2.I.166.172；2.I.166.175；2.I.166.240；2.I.166.244；2.I.169.228；2.I.169.229；2.I.169.230；2.I.169.231；2.I.169.236；2.I.169.237；
2.I.169.238；2.I.169.239；2.I.169.154；2.I.169.157；2.I.169.166；2.I.169.169；2.I.169.172；2.I.169.175；2.I.169.240；2.I.169.244；2.I.172.228；2.I.172.229；2.I.172.230；2.I.172.231；2.I.172.236；2.I.172.237；2.I.172.238；2.I.172.239；2.I.172.154；2.I.172.157；2.I.172.166；2.I.172.169；2.I.172.172；2.I.172.175；2.I.172.240；2.I.172.244；2.I.175.228；2.I.175.229；2.I.175.230；2.I.175.231；2.I.175.236；2.I.175.237；2.I.175.238；2.I.175.239；2.I.175.154；2.I.175.157；2.I.175.166；2.I.175.169；2.I.175.172；2.I.175.175；2.I.175.240；2.I.175.244；2.I.240.228；2.I.240.229；2.I.240.230；2.I.240.231；2.I.240.236；2.I.240.237；2.I.240.238；2.I.240.239；2.I.240.154；2.I.240.157；2.I.240.166；2.I.240.169；2.I.240.172；2.I.240.175；2.I.240.240；2.I.240.244；2.I.244.228；2.I.244.229；2.I.244.230；2.I.244.231；2.I.244.236；2.I.244.237；2.I.244.238；2.I.244.239；2.I.244.154；2.I.244.157；2.I.244.166；2.I.244.169；2.I.244.172；2.I.244.175；2.I.244.240；2.I.244.244；2.J的前體藥物2.J.228.228；2.J.228.229；2.J.228.230；2.J.228.231；2.J.228.236；2.J.228.237；2.J.228.238；2.J.228.239；2.J.228.154；2.J.228.157；2.J.228.166；2.J.228.169；2.J.228.172；2.J.228.175；2.J.228.240；2.J.228.244；2.J.229.228；2.J.229.229；2.J.229.230；2.J.229.231；2.J.229.236；2.J.229.237；2.J.229.238；2.J.229.239；2.J.229.154；2.J.229.157；2.J.229.166；2.J.229.169；2.J.229.172；2.J.229.175；2.J.229.240；2.J.229.244；2.J.230.228；2.J.230.229；2.J.230.230；2.J.230.231；2.J.230.236；2.J.230.237；2.J.230.238；2.J.230.239；2.J.230.154；2.J.230.157；2.J.230.166；2.J.230.169；2.J.230.172；2.J.230.175；2.J.230.240；2.J.230.244；2.J.231.228；2.J.231.229；2.J.231.230；2.J.231.231；2.J.231.236；2.J.231.237；2.J.231.238；2.J.231.239；2.J.231.154；2.J.231.157；2.J.231.166；2.J.231.169；2.J.231.172；2.J.231.175；2.J.231.240；2.J.231.244；2.J.236.228；2.J.236.229；2.J.236.230；2.J.236.231；2.J.236.236；2.J.236.237；2.J.236.238；2.J.236.239；2.J.236.154；2.J.236.157；2.J.236.166；2.J.236.169；2.J.236.172；2.J.236.175；2.J.236.240；2.J.236.244；2.J.237.228；2.J.237.229；2.J.237.230；2.J.237.231；2.J.237.236；2.J.237.237；2.J.237.238；2.J.237.239；2.J.237.154；2.J.237.157；2.J.237.166；2.J.237.169；2.J.237.172；2.J.237.175；2.J.237.240；2.J.237.244；2.J.238.228；2.J.238.229；2.J.238.230；2.J.238.231；2.J.238.236；2.J.238.237；2.J.238.238；2.J.238.239；2.J.238.154；2.J.238.157；2.J.238.166；2.J.238.169；2.J.238.172；2.J.238.175；2.J.238.240；2.J.238.244；2.J.239.228；2.J.239.229；2.J.239.230；2.J.239.231；2.J.239.236；2.J.239.237；2.J.239.238；2.J.239.239；2.J.239.154；2.J.239.157；2.J.239.166；2.J.239.169；2.J.239.172；2.J.239.175；2.J.239.240；2.J.239.244；2.J.154.228；2.J.154.229；2.J.154.230；2.J.154.231；2.J.154.236；2.J.154.237；2.J.154.238；2.J.154.239；2.J.154.154；2.J.154.157；2.J.154.166；2.J.154.169；2.J.154.172；2.J.154.175；2.J.154.240；2.J.154.244；2.J.157.228；2.J.157.229；2.J.157.230；2.J.157.231；2.J.157.236；2.J.157.237；2.J.157.238；2.J.157.239；2.J.157.154；2.J.157.157；2.J.157.166；2.J.157.169；2.J.157.172；2.J.157.175；2.J.157.240；2.J.157.244；2.J.166.228；2.J.166.229；2.J.166.230；2.J.166.231；2.J.166.236；2.J.166.237；2.J.166.238；2.J.166.239；2.J.166.154；2.J.166.157；2.J.166.166；2.J.166.169；2.J.166.172；2.J.166.175；2.J.166.240；2.J.166.244；2.J.169.228；2.J.169.229；2.J.169.230；2.J.169.231；2.J.169.236；2.J.169.237；2.J.169.238；2.J.169.239；2.J.169.154；2.J.169.157；2.J.169.166；2.J.169.169；2.J.169.172；2.J.169.175；2.J.169.240；2.J.169.244；2.J.172.228；2.J.172.229；2.J.172.230；2.J.172.231；2.J.172.236；2.J.172.237；2.J.172.238；2.J.172.239；2.J.172.154；2.J.172.157；2.J.172.166；2.J.172.169；2.J.172.172；2.J.172.175；2.J.172.240；2.J.172.244；2.J.175.228；2.J.175.229；2.J.175.230；2.J.175.231；2.J.175.236；2.J.175.237；2.J.175.238；2.J.175.239；2.J.175.154；2.J.175.157；2.J.175.166；2.J.175.169；2.J.175.172；2.J.175.175；2.J.175.240；2.J.175.244；2.J.240.228；2.J.240.229；2.J.240.230；2.J.240.231；2.J.240.236；2.J.240.237；2.J.240.238；
2.J.240.239；2.J.240.154；2.J.240.157；2.J.240.166；2.J.240.169；2.J.240.172；2.J.240.175；2.J.240.240；2.J.240.244；2.J.244.228；2.J.244.229；2.J.244.230；2.J.244.231；2.J.244.236；2.J.244.237；2.J.244.238；2.J.244.239；2.J.244.154；2.J.244.157；2.J.244.166；2.J.244.169；2.J.244.172；2.J.244.175；2.J.244.240；2.J.244.244；2.L的前體藥物2.L.228.228；2.L.228.229；2.L.228.230；2.L.228.231；2.L.228.236；2.L.228.237；2.L.228.238；2.L.228.239；2.L.228.154；2.L.228.157；2.L.228.166；2.L.228.169；2.L.228.172；2.L.228.175；2.L.228.240；2.L.228.244；2.L.229.228；2.L.229.229；2.L.229.230；2.L.229.231；2.L.229.236；2.L.229.237；2.L.229.238；2.L.229.239；2.L.229.154；2.L.229.157；2.L.229.166；2.L.229.169；2.L.229.172；2.L.229.175；2.L.229.240；2.L.229.244；2.L.230.228；2.L.230.229；2.L.230.230；2.L.230.231；2.L.230.236；2.L.230.237；2.L.230.238；2.L.230.239；2.L.230.154；2.L.230.157；2.L.230.166；2.L.230.169；2.L.230.172；2.L.230.175；2.L.230.240；2.L.230.244；2.L.231.228；2.L.231.229；2.L.231.230；2.L.231.231；2.L.231.236；2.L.231.237；2.L.231.238；2.L.231.239；2.L.231.154；2.L.231.157；2.L.231.166；2.L.231.169；2.L.231.172；2.L.231.175；2.L.231.240；2.L.231.244；2.L.236.228；2.L.236.229；2.L.236.230；2.L.236.231；2.L.236.236；2.L.236.237；2.L.236.238；2.L.236.239；2.L.236.154；2.L.236.157；2.L.236.166；2.L.236.169；2.L.236.172；2.L.236.175；2.L.236.240；2.L.236.244；2.L.237.228；2.L.237.229；2.L.237.230；2.L.237.231；2.L.237.236；2.L.237.237；2.L.237.238；2.L.237.239；2.L.237.154；2.L.237.157；2.L.237.166；2.L.237.169；2.L.237.172；2.L.237.175；2.L.237.240；2.L.237.244；2.L.238.228；2.L.238.229；2.L.238.230；2.L.238.231；2.L.238.236；2.L.238.237；2.L.238.238；2.L.238.239；2.L.238.154；2.L.238.157；2.L.238.166；2.L.238.169；2.L.238.172；2.L.238.175；2.L.238.240；2.L.238.244；2.L.239.228；2.L.239.229；2.L.239.230；2.L.239.231；2.L.239.236；2.L.239.237；2.L.239.238；2.L.239.239；2.L.239.154；2.L.239.157；2.L.239.166；2.L.239.169；2.L.239.172；2.L.239.175；2.L.239.240；2.L.239.244；2.L.154.228；2.L.154.229；2.L.154.230；2.L.154.231；2.L.154.236；2.L.154.237；2.L.154.238；2.L.154.239；2.L.154.154；2.L.154.157；2.L.154.166；2.L.154.169；2.L.154.172；2.L.154.175；2.L.154.240；2.L.154.244；2.L.157.228；2.L.157.229；2.L.157.230；2.L.157.231；2.L.157.236；2.L.157.237；2.L.157.238；2.L.157.239；2.L.157.154；2.L.157.157；2.L.157.166；2.L.157.169；2.L.157.172；2.L.157.175；2.L.157.240；2.L.157.244；2.L.166.228；2.L.166.229；2.L.166.230；2.L.166.231；2.L.166.236；2.L.166.237；2.L.166.238；2.L.166.239；2.L.166.154；2.L.166.157；2.L.166.166；2.L.166.169；2.L.166.172；2.L.166.175；2.L.166.240；2.L.166.244；2.L.169.228；2.L.169.229；2.L.169.230；2.L.169.231；2.L.169.236；2.L.169.237；2.L.169.238；2.L.169.239；2.L.169.154；2.L.169.157；2.L.169.166；2.L.169.169；2.L.169.172；2.L.169.175；2.L.169.240；2.L.169.244；2.L.172.228；2.L.172.229；2.L.172.230；2.L.172.231；2.L.172.236；2.L.172.237；2.L.172.238；2.L.172.239；2.L.172.154；2.L.172.157；2.L.172.166；2.L.172.169；2.L.172.172；2.L.172.175；2.L.172.240；2.L.172.244；2.L.175.228；2.L.175.229；2.L.175.230；2.L.175.231；2.L.175.236；2.L.175.237；2.L.175.238；2.L.175.239；2.L.175.154；2.L.175.157；2.L.175.166；2.L.175.169；2.L.175.172；2.L.175.175；2.L.175.240；2.L.175.244；2.L.240.228；2.L.240.229；2.L.240.230；2.L.240.231；2.L.240.236；2.L.240.237；2.L.240.238；2.L.240.239；2.L.240.154；2.L.240.157；2.L.240.166；2.L.240.169；2.L.240.172；2.L.240.175；2.L.240.240；2.L.240.244；
2.L.244.228；2.L.244.229；2.L.244.230；2.L.244.231；2.L.244.236；2.L.244.237；2.L.244.238；2.L.244.239；2.L.244.154；2.L.244.157；2.L.244.166；2.L.244.169；2.L.244.172；2.L.244.175；2.L.244.240；2.L.244.244；2.O的前體藥物2.O.228.228；2.O.228.229；2.O.228.230；2.O.228.231；2.O.228.236；2.O.228.237；2.O.228.238；2.O.228.239；2.O.228.154；2.O.228.157；2.O.228.166；2.O.228.169；2.O.228.172；2.O.228.175；2.O.228.240；2.O.228.244；2.O.229.228；2.O.229.229；2.O.229.230；2.O.229.231；2.O.229.236；2.O.229.237；2.O.229.238；2.O.229.239；2.O.229.154；2.O.229.157；2.O.229.166；2.O.229.169；2.O.229.172；2.O.229.175；2.O.229.240；2.O.229.244；2.O.230.228；2.O.230.229；2.O.230.230；2.O.230.231；2.O.230.236；2.O.230.237；2.O.230.238；2.O.230.239；2.O.230.154；2.O.230.157；2.O.230.166；2.O.230.169；2.O.230.172；2.O.230.175；2.O.230.240；2.O.230.244；2.O.231.228；2.O.231.229；2.O.231.230；2.O.231.231；2.O.231.236；2.O.231.237；2.O.231.238；2.O.231.239；2.O.231.154；2.O.231.157；2.O.231.166；2.O.231.169；2.O.231.172；2.O.231.175；2.O.231.240；2.O.231.244；2.O.236.228；2.O.236.229；2.O.236.230；2.O.236.231；2.O.236.236；2.O.236.237；2.O.236.238；2.O.236.239；2.O.236.154；2.O.236.157；2.O.236.166；2.O.236.169；2.O.236.172；2.O.236.175；2.O.236.240；2.O.236.244；2.O.237.228；2.O.237.229；2.O.237.230；2.O.237.231；2.O.237.236；2.O.237.237；2.O.237.238；2.O.237.239；2.O.237.154；2.O.237.157；2.O.237.166；2.O.237.169；2.O.237.172；2.O.237.175；2.O.237.240；2.O.237.244；2.O.238.228；2.O.238.229；2.O.238.230；2.O.238.231；2.O.238.236；2.O.238.237；2.O.238.238；2.O.238.239；2.O.238.154；2.O.238.157；2.O.238.166；2.O.238.169；2.O.238.172；2.O.238.175；2.O.238.240；2.O.238.244；2.O.239.228；2.O.239.229；2.O.239.230；2.O.239.231；2.O.239.236；2.O.239.237；2.O.239.238；2.O.239.239；2.O.239.154；2.O.239.157；2.O.239.166；2.O.239.169；2.O.239.172；2.O.239.175；2.O.239.240；2.O.239.244；2.O.154.228；2.O.154.229；2.O.154.230；2.O.154.231；2.O.154.236；2.O.154.237；2.O.154.238；2.O.154.239；2.O.154.154；2.O.154.157；2.O.154.166；2.O.154.169；2.O.154.172；2.O.154.175；2.O.154.240；2.O.154.244；2.O.157.228；2.O.157.229；2.O.157.230；2.O.157.231；2.O.157.236；2.O.157.237；2.O.157.238；2.O.157.239；2.O.157.154；2.O.157.157；2.O.157.166；2.O.157.169；2.O.157.172；2.O.157.175；2.O.157.240；2.O.157.244；2.O.166.228；2.O.166.229；2.O.166.230；2.O.166.231；2.O.166.236；2.O.166.237；2.O.166.238；2.O.166.239；2.O.166.154；2.O.166.157；2.O.166.166；2.O.166.169；2.O.166.172；2.O.166.175；2.O.166.240；2.O.166.244；2.O.169.228；2.O.169.229；2.O.169.230；2.O.169.231；2.O.169.236；2.O.169.237；2.O.169.238；2.O.169.239；2.O.169.154；2.O.169.157；2.O.169.166；2.O.169.169；2.O.169.172；2.O.169.175；2.O.169.240；2.O.169.244；2.O.172.228；2.O.172.229；2.O.172.230；2.O.172.231；2.O.172.236；2.O.172.237；2.O.172.238；2.O.172.239；2.O.172.154；2.O.172.157；2.O.172.166；2.O.172.169；2.O.172.172；2.O.172.175；2.O.172.240；2.O.172.244；2.O.175.228；2.O.175.229；2.O.175.230；2.O.175.231；2.O.175.236；2.O.175.237；2.O.175.238；2.O.175.239；2.O.175.154；2.O.175.157；2.O.175.166；2.O.175.169；2.O.175.172；2.O.175.175；2.O.175.240；2.O.175.244；2.O.240.228；2.O.240.229；2.O.240.230；2.O.240.231；2.O.240.236；2.O.240.237；2.O.240.238；2.O.240.239；2.O.240.154；2.O.240.157；2.O.240.166；2.O.240.169；2.O.240.172；2.O.240.175；2.O.240.240；2.O.240.244；2.O.244.228；2.O.244.229；2.O.244.230；2.O.244.231；2.O.244.236；2.O.244.237；
2.O.244.238；2.O.244.239；2.O.244.154；2.O.244.157；2.O.244.166；2.O.244.169；2.O.244.172；2.O.244.175；2.O.244.240；2.O.244.244；2.P的前體藥物2.P.228.228；2.P.228.229；2.P.228.230；2.P.228.231；2.P.228.236；2.P.228.237；2.P.228.238；2.P.228.239；2.P.228.154；2.P.228.157；2.P.228.166；2.P.228.169；2.P.228.172；2.P.228.175；2.P.228.240；2.P.228.244；2.P.229.228；2.P.229.229；2.P.229.230；2.P.229.231；2.P.229.236；2.P.229.237；2.P.229.238；2.P.229.239；2.P.229.154；2.P.229.157；2.P.229.166；2.P.229.169；2.P.229.172；2.P.229.175；2.P.229.240；2.P.229.244；2.P.230.228；2.P.230.229；2.P.230.230；2.P.230.231；2.P.230.236；2.P.230.237；2.P.230.238；2.P.230.239；2.P.230.154；2.P.230.157；2.P.230.166；2.P.230.169；2.P.230.172；2.P.230.175；2.P.230.240；2.P.230.244；2.P.231.228；2.P.231.229；2.P.231.230；2.P.231.231；2.P.231.236；2.P.231.237；2.P.231.238；2.P.231.239；2.P.231.154；2.P.231.157；2.P.231.166；2.P.231.169；2.P.231.172；2.P.231.175；2.P.231.240；2.P.231.244；2.P.236.228；2.P.236.229；2.P.236.230；2.P.236.231；2.P.236.236；2.P.236.237；2.P.236.238；2.P.236.239；2.P.236.154；2.P.236.157；2.P.236.166；2.P.236.169；2.P.236.172；2.P.236.175；2.P.236.240；2.P.236.244；2.P.237.228；2.P.237.229；2.P.237.230；2.P.237.231；2.P.237.236；2.P.237.237；2.P.237.238；2.P.237.239；2.P.237.154；2.P.237.157；2.P.237.166；2.P.237.169；2.P.237.172；2.P.237.175；2.P.237.240；2.P.237.244；2.P.238.228；2.P.238.229；2.P.238.230；2.P.238.231；2.P.238.236；2.P.238.237；2.P.238.238；2.P.238.239；2.P.238.154；2.P.238.157；2.P.238.166；2.P.238.169；2.P.238.172；2.P.238.175；2.P.238.240；2.P.238.244；2.P.239.228；2.P.239.229；2.P.239.230；2.P.239.231；2.P.239.236；2.P.239.237；2.P.239.238；2.P.239.239；2.P.239.154；2.P.239.157；2.P.239.166；2.P.239.169；2.P.239.172；2.P.239.175；2.P.239.240；2.P.239.244；2.P.154.228；2.P.154.229；2.P.154.230；2.P.154.231；2.P.154.236；2.P.154.237；2.P.154.238；2.P.154.239；2.P.154.154；2.P.154.157；2.P.154.166；2.P.154.169；2.P.154.172；2.P.154.175；2.P.154.240；2.P.154.244；2.P.157.228；2.P.157.229；2.P.157.230；2.P.157.231；2.P.157.236；2.P.157.237；2.P.157.238；2.P.157.239；2.P.157.154；2.P.157.157；2.P.157.166；2.P.157.169；2.P.157.172；2.P.157.175；2.P.157.240；2.P.157.244；2.P.166.228；2.P.166.229；2.P.166.230；2.P.166.231；2.P.166.236；2.P.166.237；2.P.166.238；2.P.166.239；2.P.166.154；2.P.166.157；2.P.166.166；2.P.166.169；2.P.166.172；2.P.166.175；2.P.166.240；2.P.166.244；2.P.169.228；2.P.169.229；2.P.169.230；2.P.169.231；2.P.169.236；2.P.169.237；2.P.169.238；2.P.169.239；2.P.169.154；2.P.169.157；2.P.169.166；2.P.169.169；2.P.169.172；2.P.169.175；2.P.169.240；2.P.169.244；2.P.172.228；2.P.172.229；2.P.172.230；2.P.172.231；2.P.172.236；2.P.172.237；2.P.172.238；2.P.172.239；2.P.172.154；2.P.172.157；2.P.172.166；2.P.172.169；2.P.172.172；2.P.172.175；2.P.172.240；2.P.172.244；2.P.175.228；2.P.175.229；2.P.175.230；2.P.175.231；2.P.175.236；2.P.175.237；2.P.175.238；2.P.175.239；2.P.175.154；2.P.175.157；2.P.175.166；2.P.175.169；2.P.175.172；2.P.175.175；2.P.175.240；2.P.175.244；2.P.240.228；2.P.240.229；2.P.240.230；2.P.240.231；2.P.240.236；2.P.240.237；2.P.240.238；2.P.240.239；2.P.240.154；2.P.240.157；2.P.240.166；2.P.240.169；2.P.240.172；2.P.240.175；2.P.240.240；2.P.240.244；2.P.244.228；2.P.244.229；2.P.244.230；2.P.244.231；2.P.244.236；2.P.244.237；2.P.244.238；2.P.244.239；2.P.244.154；2.P.244.157；2.P.244.166；2.P.244.169；2.P.244.172；2.P.244.175；2.P.244.240；2.P.244.244；2.U的前體藥物2.U.228.228；2.U.228.229；2.U.228.230；2.U.228.231；2.U.228.236；2.U.228.237；2.U.228.238；2.U.228.239；2.U.228.154；2.U.228.157；2.U.228.166；2.U.228.169；2.U.228.172；2.U.228.175；2.U.228.240；2.U.228.244；2.U.229.228；2.U.229.229；
2.U.229.230；2.U.229.231；2.U.229.236；2.U.229.237；2.U.229.238；2.U.229.239；2.U.229.154；2.U.229.157；2.U.229.166；2.U.229.169；2.U.229.172；2.U.229.175；2.U.229.240；2.U.229.244；2.U.230.228；2.U.230.229；2.U.230.230；2.U.230.231；2.U.230.236；2.U.230.237；2.U.230.238；2.U.230.239；2.U.230.154；2.U.230.157；2.U.230.166；2.U.230.169；2.U.230.172；2.U.230.175；2.U.230.240；2.U.230.244；2.U.231.228；2.U.231.229；2.U.231.230；2.U.231.231；2.U.231.236；2.U.231.237；2.U.231.238；2.U.231.239；2.U.231.154；2.U.231.157；2.U.231.166；2.U.231.169；2.U.231.172；2.U.231.175；2.U.231.240；2.U.231.244；2.U.236.228；2.U.236.229；2.U.236.230；2.U.236.231；2.U.236.236；2.U.236.237；2.U.236.238；2.U.236.239；2.U.236.154；2.U.236.157；2.U.236.166；2.U.236.169；2.U.236.172；2.U.236.175；2.U.236.240；2.U.236.244；2.U.237.228；2.U.237.229；2.U.237.230；2.U.237.231；2.U.237.236；2.U.237.237；2.U.237.238；2.U.237.239；2.U.237.154；2.U.237.157；2.U.237.166；2.U.237.169；2.U.237.172；2.U.237.175；2.U.237.240；2.U.237.244；2.U.238.228；2.U.238.229；2.U.238.230；2.U.238.231；2.U.238.236；2.U.238.237；2.U.238.238；2.U.238.239；2.U.238.154；2.U.238.157；2.U.238.166；2.U.238.169；2.U.238.172；2.U.238.175；2.U.238.240；2.U.238.244；2.U.239.228；2.U.239.229；2.U.239.230；2.U.239.231；2.U.239.236；2.U.239.237；2.U.239.238；2.U.239.239；2.U.239.154；2.U.239.157；2.U.239.166；2.U.239.169；2.U.239.172；2.U.239.175；2.U.239.240；2.U.239.244；2.U.154.228；2.U.154.229；2.U.154.230；2.U.154.231；2.U.154.236；2.U.154.237；2.U.154.238；2.U.154.239；2.U.154.154；2.U.154.157；2.U.154.166；2.U.154.169；2.U.154.172；2.U.154.175；2.U.154.240；2.U.154.244；2.U.157.228；2.U.157.229；2.U.157.230；2.U.157.231；2.U.157.236；2.U.157.237；2.U.157.238；2.U.157.239；2.U.157.154；2.U.157.157；2.U.157.166；2.U.157.169；2.U.157.172；2.U.157.175；2.U.157.240；2.U.157.244；2.U.166.228；2.U.166.229；2.U.166.230；2.U.166.231；2.U.166.236；2.U.166.237；2.U.166.238；2.U.166.239；2.U.166.154；2.U.166.157；2.U.166.166；2.U.166.169；2.U.166.172；2.U.166.175；2.U.166.240；2.U.166.244；2.U.169.228；2.U.169.229；2.U.169.230；2.U.169.231；2.U.169.236；2.U.169.237；2.U.169.238；2.U.169.239；2.U.169.154；2.U.169.157；2.U.169.166；2.U.169.169；2.U.169.172；2.U.169.175；2.U.169.240；2.U.169.244；2.U.172.228；2.U.172.229；2.U.172.230；2.U.172.231；2.U.172.236；2.U.172.237；2.U.172.238；2.U.172.239；2.U.172.154；2.U.172.157；2.U.172.166；2.U.172.169；2.U.172.172；2.U.172.175；2.U.172.240；2.U.172.244；2.U.175.228；2.U.175.229；2.U.175.230；2.U.175.231；2.U.175.236；2.U.175.237；2.U.175.238；2.U.175.239；2.U.175.154；2.U.175.157；2.U.175.166；2.U.175.169；2.U.175.172；2.U.175.175；2.U.175.240；2.U.175.244；2.U.240.228；2.U.240.229；2.U.240.230；2.U.240.231；2.U.240.236；2.U.240.237；2.U.240.238；2.U.240.239；2.U.240.154；2.U.240.157；2.U.240.166；2.U.240.169；2.U.240.172；2.U.240.175；2.U.240.240；2.U.240.244；2.U.244.228；2.U.244.229；2.U.244.230；2.U.244.231；2.U.244.236；2.U.244.237；2.U.244.238；2.U.244.239；2.U.244.154；2.U.244.157；2.U.244.166；2.U.244.169；2.U.244.172；2.U.244.175；2.U.244.240；2.U.244.244；2.W的前體藥物2.W.228.228；2.W.228.229；2.W.228.230；2.W.228.231；2.W.228.236；2.W.228.237；2.W.228.238；2.W.228.239；2.W.228.154；2.W.228.157；2.W.228.166；2.W.228.169；2.W.228.172；2.W.228.175；2.W.228.240；2.W.228.244；2.W.229.228；2.W.229.229；2.W.229.230；2.W.229.231；2.W.229.236；2.W.229.237；2.W.229.238；2.W.229.239；
2.W.229.154；2.W.229.157；2.W.229.166；2.W.229.169；2.W.229.172；2.W.229.175；2.W.229.240；2.W.229.244；2.W.230.228；2.W.230.229；2.W.230.230；2.W.230.231；2.W.230.236；2.W.230.237；2.W.230.238；2.W.230.239；2.W.230.154；2.W.230.157；2.W.230.166；2.W.230.169；2.W.230.172；2.W.230.175；2.W.230.240；2.W.230.244；2.W.231.228；2.W.231.229；2.W.231.230；2.W.231.231；2.W.231.236；2.W.231.237；2.W.231.238；2.W.231.239；2.W.231.154；2.W.231.157；2.W.231.166；2.W.231.169；2.W.231.172；2.W.231.175；2.W.231.240；2.W.231.244；2.W.236.228；2.W.236.229；2.W.236.230；2.W.236.231；2.W.236.236；2.W.236.237；2.W.236.238；2.W.236.239；2.W.236.154；2.W.236.157；2.W.236.166；2.W.236.169；2.W.236.172；2.W.236.175；2.W.236.240；2.W.236.244；2.W.237.228；2.W.237.229；2.W.237.230；2.W.237.231；2.W.237.236；2.W.237.237；2.W.237.238；2.W.237.239；2.W.237.154；2.W.237.157；2.W.237.166；2.W.237.169；2.W.237.172；2.W.237.175；2.W.237.240；2.W.237.244；2.W.238.228；2.W.238.229；2.W.238.230；2.W.238.231；2.W.238.236；2.W.238.237；2.W.238.238；2.W.238.239；2.W.238.154；2.W.238.157；2.W.238.166；2.W.238.169；2.W.238.172；2.W.238.175；2.W.238.240；2.W.238.244；2.W.239.228；2.W.239.229；2.W.239.230；2.W.239.231；2.W.239.236；2.W.239.237；2.W.239.238；2.W.239.239；2.W.239.154；2.W.239.157；2.W.239.166；2.W.239.169；2.W.239.172；2.W.239.175；2.W.239.240；2.W.239.244；2.W.154.228；2.W.154.229；2.W.154.230；2.W.154.231；2.W.154.236；2.W.154.237；2.W.154.238；2.W.154.239；2.W.154.154；2.W.154.157；2.W.154.166；2.W.154.169；2.W.154.172；2.W.154.175；2.W.154.240；2.W.154.244；2.W.157.228；2.W.157.229；2.W.157.230；2.W.157.231；2.W.157.236；2.W.157.237；2.W.157.238；2.W.157.239；2.W.157.154；2.W.157.157；2.W.157.166；2.W.157.169；2.W.157.172；2.W.157.175；2.W.157.240；2.W.157.244；2.W.166.228；2.W.166.229；2.W.166.230；2.W.166.231；2.W.166.236；2.W.166.237；2.W.166.238；2.W.166.239；2.W.166.154；2.W.166.157；2.W.166.166；2.W.166.169；2.W.166.172；2.W.166.175；2.W.166.240；2.W.166.244；2.W.169.228；2.W.169.229；2.W.169.230；2.W.169.231；2.W.169.236；2.W.169.237；2.W.169.238；2.W.169.239；2.W.169.154；2.W.169.157；2.W.169.166；2.W.169.169；2.W.169.172；2.W.169.175；2.W.169.240；2.W.169.244；2.W.172.228；2.W.172.229；2.W.172.230；2.W.172.231；2.W.172.236；2.W.172.237；2.W.172.238；2.W.172.239；2.W.172.154；2.W.172.157；2.W.172.166；2.W.172.169；2.W.172.172；2.W.172.175；2.W.172.240；2.W.172.244；2.W.175.228；2.W.175.229；2.W.175.230；2.W.175.231；2.W.175.236；2.W.175.237；2.W.175.238；2.W.175.239；2.W.175.154；2.W.175.157；2.W.175.166；2.W.175.169；2.W.175.172；2.W.175.175；2.W.175.240；2.W.175.244；2.W.240.228；2.W.240.229；2.W.240.230；2.W.240.231；2.W.240.236；2.W.240.237；2.W.240.238；2.W.240.239；2.W.240.154；2.W.240.157；2.W.240.166；2.W.240.169；2.W.240.172；2.W.240.175；2.W.240.240；2.W.240.244；2.W.244.228；2.W.244.229；2.W.244.230；2.W.244.231；2.W.244.236；2.W.244.237；2.W.244.238；2.W.244.239；2.W.244.154；2.W.244.157；2.W.244.166；2.W.244.169；2.W.244.172；2.W.244.175；2.W.244.240；2.W.244.244；2.Y的前體藥物2.Y.228.228；2.Y.228.229；2.Y.228.230；2.Y.228.231；2.Y.228.236；2.Y.228.237；2.Y.228.238；2.Y.228.239；2.Y.228.154；2.Y.228.157；2.Y.228.166；2.Y.228.169；2.Y.228.172；2.Y.228.175；2.Y.228.240；2.Y.228.244；2.Y.229.228；2.Y.229.229；2.Y.229.230；2.Y.229.231；2.Y.229.236；2.Y.229.237；2.Y.229.238；2.Y.229.239；2.Y.229.154；2.Y.229.157；2.Y.229.166；2.Y.229.169；2.Y.229.172；2.Y.229.175；
2.Y.229.240；2.Y.229.244；2.Y.230.228；2.Y.230.229；2.Y.230.230；2.Y.230.231；2.Y.230.236；2.Y.230.237；2.Y.230.238；2.Y.230.239；2.Y.230.154；2.Y.230.157；2.Y.230.166；2.Y.230.169；2.Y.230.172；2.Y.230.175；2.Y.230.240；2.Y.230.244；2.Y.231.228；2.Y.231.229；2.Y.231.230；2.Y.231.231；2.Y.231.236；2.Y.231.237；2.Y.231.238；2.Y.231.239；2.Y.231.154；2.Y.231.157；2.Y.231.166；2.Y.231.169；2.Y.231.172；2.Y.231.175；2.Y.231.240；2.Y.231.244；2.Y.236.228；2.Y.236.229；2.Y.236.230；2.Y.236.231；2.Y.236.236；2.Y.236.237；2.Y.236.238；2.Y.236.239；2.Y.236.154；2.Y.236.157；2.Y.236.166；2.Y.236.169；2.Y.236.172；2.Y.236.175；2.Y.236.240；2.Y.236.244；2.Y.237.228；2.Y.237.229；2.Y.237.230；2.Y.237.231；2.Y.237.236；2.Y.237.237；2.Y.237.238；2.Y.237.239；2.Y.237.154；2.Y.237.157；2.Y.237.166；2.Y.237.169；2.Y.237.172；2.Y.237.175；2.Y.237.240；2.Y.237.244；2.Y.238.228；2.Y.238.229；2.Y.238.230；2.Y.238.231；2.Y.238.236；2.Y.238.237；2.Y.238.238；2.Y.238.239；2.Y.238.154；2.Y.238.157；2.Y.238.166；2.Y.238.169；2.Y.238.172；2.Y.238.175；2.Y.238.240；2.Y.238.244；2.Y.239.228；2.Y.239.229；2.Y.239.230；2.Y.239.231；2.Y.239.236；2.Y.239.237；2.Y.239.238；2.Y.239.239；2.Y.239.154；2.Y.239.157；2.Y.239.166；2.Y.239.169；2.Y.239.172；2.Y.239.175；2.Y.239.240；2.Y.239.244；2.Y.154.228；2.Y.154.229；2.Y.154.230；2.Y.154.231；2.Y.154.236；2.Y.154.237；2.Y.154.238；2.Y.154.239；2.Y.154.154；2.Y.154.157；2.Y.154.166；2.Y.154.169；2.Y.154.172；2.Y.154.175；2.Y.154.240；2.Y.154.244；2.Y.157.228；2.Y.157.229；2.Y.157.230；2.Y.157.231；2.Y.157.236；2.Y.157.237；2.Y.157.238；2.Y.157.239；2.Y.157.154；2.Y.157.157；2.Y.157.166；2.Y.157.169；2.Y.157.172；2.Y.157.175；2.Y.157.240；2.Y.157.244；2.Y.166.228；2.Y.166.229；2.Y.166.230；2.Y.166.231；2.Y.166.236；2.Y.166.237；2.Y.166.238；2.Y.166.239；2.Y.166.154；2.Y.166.157；2.Y.166.166；2.Y.166.169；2.Y.166.172；2.Y.166.175；2.Y.166.240；2.Y.166.244；2.Y.169.228；2.Y.169.229；2.Y.169.230；2.Y.169.231；2.Y.169.236；2.Y.169.237；2.Y.169.238；2.Y.169.239；2.Y.169.154；2.Y.169.157；2.Y.169.166；2.Y.169.169；2.Y.169.172；2.Y.169.175；2.Y.169.240；2.Y.169.244；2.Y.172.228；2.Y.172.229；2.Y.172.230；2.Y.172.231；2.Y.172.236；2.Y.172.237；2.Y.172.238；2.Y.172.239；2.Y.172.154；2.Y.172.157；2.Y.172.166；2.Y.172.169；2.Y.172.172；2.Y.172.175；2.Y.172.240；2.Y.172.244；2.Y.175.228；2.Y.175.229；2.Y.175.230；2.Y.175.231；2.Y.175.236；2.Y.175.237；2.Y.175.238；2.Y.175.239；2.Y.175.154；2.Y.175.157；2.Y.175.166；2.Y.175.169；2.Y.175.172；2.Y.175.175；2.Y.175.240；2.Y.175.244；2.Y.240.228；2.Y.240.229；2.Y.240.230；2.Y.240.231；2.Y.240.236；2.Y.240.237；2.Y.240.238；2.Y.240.239；2.Y.240.154；2.Y.240.157；2.Y.240.166；2.Y.240.169；2.Y.240.172；2.Y.240.175；2.Y.240.240；2.Y.240.244；2.Y.244.228；2.Y.244.229；2.Y.244.230；2.Y.244.231；2.Y.244.236；2.Y.244.237；2.Y.244.238；2.Y.244.239；2.Y.244.154；2.Y.244.157；2.Y.244.166；2.Y.244.169；2.Y.244.172；2.Y.244.175；2.Y.244.240；2.Y.244.244；3.B的前體藥物3.B.228.228；3.B.228.229；3.B.228.230；3.B.228.231；3.B.228.236；3.B.228.237；3.B.228.238；3.B.228.239；3.B.228.154；3.B.228.157；3.B.228.166；3.B.228.169；3.B.228.172；3.B.228.175；3.B.228.240；3.B.228.244；3.B.229.228；3.B.229.229；3.B.229.230；3.B.229.231；3.B.229.236；3.B.229.237；3.B.229.238；3.B.229.239；3.B.229.154；3.B.229.157；3.B.229.166；3.B.229.169；3.B.229.172；3.B.229.175；3.B.229.240；3.B.229.244；3.B.230.228；3.B.230.229；3.B.230.230；3.B.230.231；
3.B.230.236；3.B.230.237；3.B.230.238；3.B.230.239；3.B.230.154；3.B.230.157；3.B.230.166；3.B.230.169；3.B.230.172；3.B.230.175；3.B.230.240；3.B.230.244；3.B.231.228；3.B.231.229；3.B.231.230；3.B.231.231；3.B.231.236；3.B.231.237；3.B.231.238；3.B.231.239；3.B.231.154；3.B.231.157；3.B.231.166；3.B.231.169；3.B.231.172；3.B.231.175；3.B.231.240；3.B.231.244；3.B.236.228；3.B.236.229；3.B.236.230；3.B.236.231；3.B.236.236；3.B.236.237；3.B.236.238；3.B.236.239；3.B.236.154；3.B.236.157；3.B.236.166；3.B.236.169；3.B.236.172；3.B.236.175；3.B.236.240；3.B.236.244；3.B.237.228；3.B.237.229；3.B.237.230；3.B.237.231；3.B.237.236；3.B.237.237；3.B.237.238；3.B.237.239；3.B.237.154；3.B.237.157；3.B.237.166；3.B.237.169；3.B.237.172；3.B.237.175；3.B.237.240；3.B.237.244；3.B.238.228；3.B.238.229；3.B.238.230；3.B.238.231；3.B.238.236；3.B.238.237；3.B.238.238；3.B.238.239；3.B.238.154；3.B.238.157；3.B.238.166；3.B.238.169；3.B.238.172；3.B.238.175；3.B.238.240；3.B.238.244；3.B.239.228；3.B.239.229；3.B.239.230；3.B.239.231；3.B.239.236；3.B.239.237；3.B.239.238；3.B.239.239；3.B.239.154；3.B.239.157；3.B.239.166；3.B.239.169；3.B.239.172；3.B.239.175；3.B.239.240；3.B.239.244；3.B.154.228；3.B.154.229；3.B.154.230；3.B.154.231；3.B.154.236；3.B.154.237；3.B.154.238；3.B.154.239；3.B.154.154；3.B.154.157；3.B.154.166；3.B.154.169；3.B.154.172；3.B.154.175；3.B.154.240；3.B.154.244；3.B.157.228；3.B.157.229；3.B.157.230；3.B.157.231；3.B.157.236；3.B.157.237；3.B.157.238；3.B.157.239；3.B.157.154；3.B.157.157；3.B.157.166；3.B.157.169；3.B.157.172；3.B.157.175；3.B.157.240；3.B.157.244；3.B.166.228；3.B.166.229；3.B.166.230；3.B.166.231；3.B.166.236；3.B.166.237；3.B.166.238；3.B.166.239；3.B.166.154；3.B.166.157；3.B.166.166；3.B.166.169；3.B.166.172；3.B.166.175；3.B.166.240；3.B.166.244；3.B.169.228；3.B.169.229；3.B.169.230；3.B.169.231；3.B.169.236；3.B.169.237；3.B.169.238；3.B.169.239；3.B.169.154；3.B.169.157；3.B.169.166；3.B.169.169；3.B.169.172；3.B.169.175；3.B.169.240；3.B.169.244；3.B.172.228；3.B.172.229；3.B.172.230；3.B.172.231；3.B.172.236；3.B.172.237；3.B.172.238；3.B.172.239；3.B.172.154；3.B.172.157；3.B.172.166；3.B.172.169；3.B.172.172；3.B.172.175；3.B.172.240；3.B.172.244；3.B.175.228；3.B.175.229；3.B.175.230；3.B.175.231；3.B.175.236；3.B.175.237；3.B.175.238；3.B.175.239；3.B.175.154；3.B.175.157；3.B.175.166；3.B.175.169；3.B.175.172；3.B.175.175；3.B.175.240；3.B.175.244；3.B.240.228；3.B.240.229；3.B.240.230；3.B.240.231；3.B.240.236；3.B.240.237；3.B.240.238；3.B.240.239；3.B.240.154；3.B.240.157；3.B.240.166；3.B.240.169；3.B.240.172；3.B.240.175；3.B.240.240；3.B.240.244；3.B.244.228；3.B.244.229；3.B.244.230；3.B.244.231；3.B.244.236；3.B.244.237；3.B.244.238；3.B.244.239；3.B.244.154；3.B.244.157；3.B.244.166；3.B.244.169；3.B.244.172；3.B.244.175；3.B.244.240；3.B.244.244；3.D的前體藥物3.D.228.228；3.D.228.229；3.D.228.230；3.D.228.231；3.D.228.236；3.D.228.237；3.D.228.238；3.D.228.239；3.D.228.154；3.D.228.157；3.D.228.166；3.D.228.169；3.D.228.172；3.D.228.175；3.D.228.240；3.D.228.244；3.D.229.228；3.D.229.229；3.D.229.230；3.D.229.231；3.D.229.236；3.D.229.237；3.D.229.238；3.D.229.239；3.D.229.154；3.D.229.157；3.D.229.166；3.D.229.169；3.D.229.172；3.D.229.175；3.D.229.240；3.D.229.244；3.D.230.228；3.D.230.229；3.D.230.230；3.D.230.231；3.D.230.236；3.D.230.237；3.D.230.238；3.D.230.239；3.D.230.154；3.D.230.157；
3.D.230.166；3.D.230.169；3.D.230.172；3.D.230.175；3.D.230.240；3.D.230.244；3.D.231.228；3.D.231.229；3.D.231.230；3.D.231.231；3.D.231.236；3.D.231.237；3.D.231.238；3.D.231.239；3.D.231.154；3.D.231.157；3.D.231.166；3.D.231.169；3.D.231.172；3.D.231.175；3.D.231.240；3.D.231.244；3.D.236.228；3.D.236.229；3.D.236.230；3.D.236.231；3.D.236.236；3.D.236.237；3.D.236.238；3.D.236.239；3.D.236.154；3.D.236.157；3.D.236.166；3.D.236.169；3.D.236.172；3.D.236.175；3.D.236.240；3.D.236.244；3.D.237.228；3.D.237.229；3.D.237.230；3.D.237.231；3.D.237.236；3.D.237.237；3.D.237.238；3.D.237.239；3.D.237.154；3.D.237.157；3.D.237.166；3.D.237.169；3.D.237.172；3.D.237.175；3.D.237.240；3.D.237.244；3.D.238.228；3.D.238.229；3.D.238.230；3.D.238.231；3.D.238.236；3.D.238.237；3.D.238.238；3.D.238.239；3.D.238.154；3.D.238.157；3.D.238.166；3.D.238.169；3.D.238.172；3.D.238.175；3.D.238.240；3.D.238.244；3.D.239.228；3.D.239.229；3.D.239.230；3.D.239.231；3.D.239.236；3.D.239.237；3.D.239.238；3.D.239.239；3.D.239.154；3.D.239.157；3.D.239.166；3.D.239.169；3.D.239.172；3.D.239.175；3.D.239.240；3.D.239.244；3.D.154.228；3.D.154.229；3.D.154.230；3.D.154.231；3.D.154.236；3.D.154.237；3.D.154.238；3.D.154.239；3.D.154.154；3.D.154.157；3.D.154.166；3.D.154.169；3.D.154.172；3.D.154.175；3.D.154.240；3.D.154.244；3.D.157.228；3.D.157.229；3.D.157.230；3.D.157.231；3.D.157.236；3.D.157.237；3.D.157.238；3.D.157.239；3.D.157.154；3.D.157.157；3.D.157.166；3.D.157.169；3.D.157.172；3.D.157.175；3.D.157.240；3.D.157.244；3.D.166.228；3.D.166.229；3.D.166.230；3.D.166.231；3.D.166.236；3.D.166.237；3.D.166.238；3.D.166.239；3.D.166.154；3.D.166.157；3.D.166.166；3.D.166.169；3.D.166.172；3.D.166.175；3.D.166.240；3.D.166.244；3.D.169.228；3.D.169.229；3.D.169.230；3.D.169.231；3.D.169.236；3.D.169.237；3.D.169.238；3.D.169.239；3.D.169.154；3.D.169.157；3.D.169.166；3.D.169.169；3.D.169.172；3.D.169.175；3.D.169.240；3.D.169.244；3.D.172.228；3.D.172.229；3.D.172.230；3.D.172.231；3.D.172.236；3.D.172.237；3.D.172.238；3.D.172.239；3.D.172.154；3.D.172.157；3.D.172.166；3.D.172.169；3.D.172.172；3.D.172.175；3.D.172.240；3.D.172.244；3.D.175.228；3.D.175.229；3.D.175.230；3.D.175.231；3.D.175.236；3.D.175.237；3.D.175.238；3.D.175.239；3.D.175.154；3.D.175.157；3.D.175.166；3.D.175.169；3.D.175.172；3.D.175.175；3.D.175.240；3.D.175.244；3.D.240.228；3.D.240.229；3.D.240.230；3.D.240.231；3.D.240.236；3.D.240.237；3.D.240.238；3.D.240.239；3.D.240.154；3.D.240.157；3.D.240.166；3.D.240.169；3.D.240.172；3.D.240.175；3.D.240.240；3.D.240.244；3.D.244.228；3.D.244.229；3.D.244.230；3.D.244.231；3.D.244.236；3.D.244.237；3.D.244.238；3.D.244.239；3.D.244.154；3.D.244.157；3.D.244.166；3.D.244.169；3.D.244.172；3.D.244.175；3.D.244.240；3.D.244.244；3.E的前體藥物3.E.228.228；3.E.228.229；3.E.228.230；3.E.228.231；3.E.228.236；3.E.228.237；3.E.228.238；3.E.228.239；3.E.228.154；3.E.228.157；3.E.228.166；3.E.228.169；3.E.228.172；3.E.228.175；3.E.228.240；3.E.228.244；3.E.229.228；3.E.229.229；3.E.229.230；3.E.229.231；3.E.229.236；3.E.229.237；3.E.229.238；3.E.229.239；3.E.229.154；3.E.229.157；3.E.229.166；3.E.229.169；3.E.229.172；3.E.229.175；3.E.229.240；3.E.229.244；3.E.230.228；3.E.230.229；3.E.230.230；3.E.230.231；3.E.230.236；3.E.230.237；3.E.230.238；3.E.230.239；3.E.230.154；3.E.230.157；3.E.230.166；3.E.230.169；3.E.230.172；3.E.230.175；3.E.230.240；3.E.230.244；
3.E.231.228；3.E.231.229；3.E.231.230；3.E.231.231；3.E.231.236；3.E.231.237；3.E.231.238；3.E.231.239；3.E.231.154；3.E.231.157；3.E.231.166；3.E.231.169；3.E.231.172；3.E.231.175；3.E.231.240；3.E.231.244；3.E.236.228；3.E.236.229；3.E.236.230；3.E.236.231；3.E.236.236；3.E.236.237；3.E.236.238；3.E.236.239；3.E.236.154；3.E.236.157；3.E.236.166；3.E.236.169；3.E.236.172；3.E.236.175；3.E.236.240；3.E.236.244；3.E.237.228；3.E.237.229；3.E.237.230；3.E.237.231；3.E.237.236；3.E.237.237；3.E.237.238；3.E.237.239；3.E.237.154；3.E.237.157；3.E.237.166；3.E.237.169；3.E.237.172；3.E.237.175；3.E.237.240；3.E.237.244；3.E.238.228；3.E.238.229；3.E.238.230；3.E.238.231；3.E.238.236；3.E.238.237；3.E.238.238；3.E.238.239；3.E.238.154；3.E.238.157；3.E.238.166；3.E.238.169；3.E.238.172；3.E.238.175；3.E.238.240；3.E.238.244；3.E.239.228；3.E.239.229；3.E.239.230；3.E.239.231；3.E.239.236；3.E.239.237；3.E.239.238；3.E.239.239；3.E.239.154；3.E.239.157；3.E.239.166；3.E.239.169；3.E.239.172；3.E.239.175；3.E.239.240；3.E.239.244；3.E.154.228；3.E.154.229；3.E.154.230；3.E.154.231；3.E.154.236；3.E.154.237；3.E.154.238；3.E.154.239；3.E.154.154；3.E.154.157；3.E.154.166；3.E.154.169；3.E.154.172；3.E.154.175；3.E.154.240；3.E.154.244；3.E.157.228；3.E.157.229；3.E.157.230；3.E.157.231；3.E.157.236；3.E.157.237；3.E.157.238；3.E.157.239；3.E.157.154；3.E.157.157；3.E.157.166；3.E.157.169；3.E.157.172；3.E.157.175；3.E.157.240；3.E.157.244；3.E.166.228；3.E.166.229；3.E.166.230；3.E.166.231；3.E.166.236；3.E.166.237；3.E.166.238；3.E.166.239；3.E.166.154；3.E.166.157；3.E.166.166；3.E.166.169；3.E.166.172；3.E.166.175；3.E.166.240；3.E.166.244；3.E.169.228；3.E.169.229；3.E.169.230；3.E.169.231；3.E.169.236；3.E.169.237；3.E.169.238；3.E.169.239；3.E.169.154；3.E.169.157；3.E.169.166；3.E.169.169；3.E.169.172；3.E.169.175；3.E.169.240；3.E.169.244；3.E.172.228；3.E.172.229；3.E.172.230；3.E.172.231；3.E.172.236；3.E.172.237；3.E.172.238；3.E.172.239；3.E.172.154；3.E.172.157；3.E.172.166；3.E.172.169；3.E.172.172；3.E.172.175；3.E.172.240；3.E.172.244；3.E.175.228；3.E.175.229；3.E.175.230；3.E.175.231；3.E.175.236；3.E.175.237；3.E.175.238；3.E.175.239；3.E.175.154；3.E.175.157；3.E.175.166；3.E.175.169；3.E.175.172；3.E.175.175；3.E.175.240；3.E.175.244；3.E.240.228；3.E.240.229；3.E.240.230；3.E.240.231；3.E.240.236；3.E.240.237；3.E.240.238；3.E.240.239；3.E.240.154；3.E.240.157；3.E.240.166；3.E.240.169；3.E.240.172；3.E.240.175；3.E.240.240；3.E.240.244；3.E.244.228；3.E.244.229；3.E.244.230；3.E.244.231；3.E.244.236；3.E.244.237；3.E.244.238；3.E.244.239；3.E.244.154；3.E.244.157；3.E.244.166；3.E.244.169；3.E.244.172；3.E.244.175；3.E.244.240；3.E.244.244；3.G的前體藥物3.G.228.228；3.G.228.229；3.G.228.230；3.G.228.231；3.G.228.236；3.G.228.237；3.G.228.238；3.G.228.239；3.G.228.154；3.G.228.157；3.G.228.166；3.G.228.169；3.G.228.172；3.G.228.175；3.G.228.240；3.G.228.244；3.G.229.228；3.G.229.229；3.G.229.230；3.G.229.231；3.G.229.236；3.G.229.237；3.G.229.238；3.G.229.239；3.G.229.154；3.G.229.157；3.G.229.166；3.G.229.169；3.G.229.172；3.G.229.175；3.G.229.240；3.G.229.244；3.G.230.228；3.G.230.229；3.G.230.230；3.G.230.231；3.G.230.236；3.G.230.237；3.G.230.238；3.G.230.239；3.G.230.154；3.G.230.157；3.G.230.166；3.G.230.169；3.G.230.172；3.G.230.175；3.G.230.240；3.G.230.244；3.G.231.228；3.G.231.229；3.G.231.230；3.G.231.231；3.G.231.236；3.G.231.237；
3.G.231.238；3.G.231.239；3.G.231.154；3.G.231.157；3.G.231.166；3.G.231.169；3.G.231.172；3.G.231.175；3.G.231.240；3.G.231.244；3.G.236.228；3.G.236.229；3.G.236.230；3.G.236.231；3.G.236.236；3.G.236.237；3.G.236.238；3.G.236.239；3.G.236.154；3.G.236.157；3.G.236.166；3.G.236.169；3.G.236.172；3.G.236.175；3.G.236.240；3.G.236.244；3.G.237.228；3.G.237.229；3.G.237.230；3.G.237.231；3.G.237.236；3.G.237.237；3.G.237.238；3.G.237.239；3.G.237.154；3.G.237.157；3.G.237.166；3.G.237.169；3.G.237.172；3.G.237.175；3.G.237.240；3.G.237.244；3.G.238.228；3.G.238.229；3.G.238.230；3.G.238.231；3.G.238.236；3.G.238.237；3.G.238.238；3.G.238.239；3.G.238.154；3.G.238.157；3.G.238.166；3.G.238.169；3.G.238.172；3.G.238.175；3.G.238.240；3.G.238.244；3.G.239.228；3.G.239.229；3.G.239.230；3.G.239.231；3.G.239.236；3.G.239.237；3.G.239.238；3.G.239.239；3.G.239.154；3.G.239.157；3.G.239.166；3.G.239.169；3.G.239.172；3.G.239.175；3.G.239.240；3.G.239.244；3.G.154.228；3.G.154.229；3.G.154.230；3.G.154.231；3.G.154.236；3.G.154.237；3.G.154.238；3.G.154.239；3.G.154.154；3.G.154.157；3.G.154.166；3.G.154.169；3.G.154.172；3.G.154.175；3.G.154.240；3.G.154.244；3.G.157.228；3.G.157.229；3.G.157.230；3.G.157.231；3.G.157.236；3.G.157.237；3.G.157.238；3.G.157.239；3.G.157.154；3.G.157.157；3.G.157.166；3.G.157.169；3.G.157.172；3.G.157.175；3.G.157.240；3.G.157.244；3.G.166.228；3.G.166.229；3.G.166.230；3.G.166.231；3.G.166.236；3.G.166.237；3.G.166.238；3.G.166.239；3.G.166.154；3.G.166.157；3.G.166.166；3.G.166.169；3.G.166.172；3.G.166.175；3.G.166.240；3.G.166.244；3.G.169.228；3.G.169.229；3.G.169.230；3.G.169.231；3.G.169.236；3.G.169.237；3.G.169.238；3.G.169.239；3.G.169.154；3.G.169.157；3.G.169.166；3.G.169.169；3.G.169.172；3.G.169.175；3.G.169.240；3.G.169.244；3.G.172.228；3.G.172.229；3.G.172.230；3.G.172.231；3.G.172.236；3.G.172.237；3.G.172.238；3.G.172.239；3.G.172.154；3.G.172.157；3.G.172.166；3.G.172.169；3.G.172.172；3.G.172.175；3.G.172.240；3.G.172.244；3.G.175.228；3.G.175.229；3.G.175.230；3.G.175.231；3.G.175.236；3.G.175.237；3.G.175.238；3.G.175.239；3.G.175.154；3.G.175.157；3.G.175.166；3.G.175.169；3.G.175.172；3.G.175.175；3.G.175.240；3.G.175.244；3.G.240.228；3.G.240.229；3.G.240.230；3.G.240.231；3.G.240.236；3.G.240.237；3.G.240.238；3.G.240.239；3.G.240.154；3.G.240.157；3.G.240.166；3.G.240.169；3.G.240.172；3.G.240.175；3.G.240.240；3.G.240.244；3.G.244.228；3.G.244.229；3.G.244.230；3.G.244.231；3.G.244.236；3.G.244.237；3.G.244.238；3.G.244.239；3.G.244.154；3.G.244.157；3.G.244.166；3.G.244.169；3.G.244.172；3.G.244.175；3.G.244.240；3.G.244.244；3.I的前體藥物3.I.228.228；3.I.228.229；3.I.228.230；3.I.228.231；3.I.228.236；3.I.228.237；3.I.228.238；3.I.228.239；3.I.228.154；3.I.228.157；3.I.228.166；3.I.228.169；3.I.228.172；3.I.228.175；3.I.228.240；3.I.228.244；3.I.229.228；3.I.229.229；3.I.229.230；3.I.229.231；3.I.229.236；3.I.229.237；3.I.229.238；3.I.229.239；3.I.229.154；3.I.229.157；3.I.229.166；3.I.229.169；3.I.229.172；3.I.229.175；3.I.229.240；3.I.229.244；3.I.230.228；3.I.230.229；3.I.230.230；3.I.230.231；3.I.230.236；3.I.230.237；3.I.230.238；3.I.230.239；3.I.230.154；3.I.230.157；3.I.230.166；3.I.230.169；3.I.230.172；3.I.230.175；3.I.230.240；3.I.230.244；3.I.231.228；3.I.231.229；3.I.231.230；3.I.231.231；3.I.231.236；3.I.231.237；3.I.231.238；3.I.231.239；3.I.231.154；3.I.231.157；3.I.231.166；3.I.231.169；3.I.231.172；3.I.231.175；3.I.231.240；3.I.231.244；3.I.236.228；3.I.236.229；3.I.236.230；3.I.236.231；3.I.236.236；3.I.236.237；
3.I.236.238；3.I.236.239；3.I.236.154；3.I.236.157；3.I.236.166；3.I.236.169；3.I.236.172；3.I.236.175；3.I.236.240；3.I.236.244；3.I.237.228；3.I.237.229；3.I.237.230；3.I.237.231；3.I.237.236；3.I.237.237；3.I.237.238；3.I.237.239；3.I.237.154；3.I.237.157；3.I.237.166；3.I.237.169；3.I.237.172；3.I.237.175；3.I.237.240；3.I.237.244；3.I.238.228；3.I.238.229；3.I.238.230；3.I.238.231；3.1.238.236；3.I.238.237；3.I.238.238；3.I.238.239；3.I.238.154；3.I.238.157；3.I.238.166；3.I.238.169；3.I.238.172；3.I.238.175；3.I.238.240；3.I.238.244；3.I.239.228；3.I.239.229；3.I.239.230；3.I.239.231；3.I.239.236；3.I.239.237；3.I.239.238；3.I.239.239；3.I.239.154；3.I.239.157；3.I.239.166；3.I.239.169；3.I.239.172；3.I.239.175；3.I.239.240；3.I.239.244；3.I.154.228；3.I.154.229；3.I.154.230；3.I.154.231；3.I.154.236；3.I.154.237；3.I.154.238；3.I.154.239；3.I.154.154；3.I.154.157；3.I.154.166；3.I.154.169；3.I.154.172；3.I.154.175；3.I.154.240；3.I.154.244；3.I.157.228；3.I.157.229；3.I.157.230；3.I.157.231；3.I.157.236；3.I.157.237；3.I.157.238；3.I.157.239；3.I.157.154；3.I.157.157；3.I.157.166；3.I.157.169；3.I.157.172；3.I.157.175；3.I.157.240；3.I.157.244；3.I.166.228；3.I.166.229；3.I.166.230；3.I.166.231；3.I.166.236；3.I.166.237；3.I.166.238；3.I.166.239；3.I.166.154；3.I.166.157；3.I.166.166；3.I.166.169；3.I.166.172；3.I.166.175；3.I.166.240；3.I.166.244；3.I.169.228；3.I.169.229；3.I.169.230；3.I.169.231；3.I.169.236；3.I.169.237；3.I.169.238；3.I.169.239；3.I.169.154；3.I.169.157；3.I.169.166；3.I.169.169；3.I.169.172；3.I.169.175；3.I.169.240；3.I.169.244；3.I.172.228；3.I.172.229；3.I.172.230；3.I.172.231；3.I.172.236；3.I.172.237；3.I.172.238；3.I.172.239；3.I.172.154；3.I.172.157；3.I.172.166；3.I.172.169；3.I.172.172；3.I.172.175；3.I.172.240；3.I.172.244；3.I.175.228；3.I.175.229；3.I.175.230；3.I.175.231；3.I.175.236；3.I.175.237；3.I.175.238；3.I.175.239；3.I.175.154；3.I.175.157；3.I.175.166；3.I.175.169；3.I.175.172；3.I.175.175；3.I.175.240；3.I.175.244；3.I.240.228；3.I.240.229；3.I.240.230；3.I.240.231；3.I.240.236；3.I.240.237；3.I.240.238；3.I.240.239；3.I.240.154；3.I.240.157；3.I.240.166；3.I.240.169；3.I.240.172；3.I.240.175；3.I.240.240；3.I.240.244；3.I.244.228；3.I.244.229；3.I.244.230；3.I.244.231；3.I.244.236；3.I.244.237；3.I.244.238；3.I.244.239；3.I.244.154；3.I.244.157；3.I.244.166；3.I.244.169；3.I.244.172；3.I.244.175；3.I.244.240；3.I.244.244；3.J的前體藥物3.J.228.228；3.J.228.229；3.J.228.230；3.J.228.231；3.J.228.236；3.J.228.237；3.J.228.238；3.J.228.239；3.J.228.154；3.J.228.157；3.J.228.166；3.J.228.169；3.J.228.172；3.J.228.175；3.J.228.240；3.J.228.244；3.J.229.228；3.J.229.229；3.J.229.230；3.J.229.231；3.J.229.236；3.J.229.237；3.J.229.238；3.J.229.239；3.J.229.154；3.J.229.157；3.J.229.166；3.J.229.169；3.J.229.172；3.J.229.175；3.J.229.240；3.J.229.244；3.J.230.228；3.J.230.229；3.J.230.230；3.J.230.231；3.J.230.236；3.J.230.237；3.J.230.238；3.J.230.239；3.J.230.154；3.J.230.157；3.J.230.166；3.J.230.169；3.J.230.172；3.J.230.175；3.J.230.240；3.J.230.244；3.J.231.228；3.J.231.229；3.J.231.230；3.J.231.231；3.J.231.236；3.J.231.237；3.J.231.238；3.J.231.239；3.J.231.154；3.J.231.157；3.J.231.166；3.J.231.169；3.J.231.172；3.J.231.175；3.J.231.240；3.J.231.244；3.J.236.228；3.J.236.229；3.J.236.230；3.J.236.231；3.J.236.236；3.J.236.237；3.J.236.238；3.J.236.239；3.J.236.154；3.J.236.157；3.J.236.166；3.J.236.169；3.J.236.172；3.J.236.175；3.J.236.240；3.J.236.244；3.J.237.228；3.J.237.229；3.J.237.230；3.J.237.231；3.J.237.236；3.J.237.237；3.J.237.238；3.J.237.239；3.J.237.154；3.J.237.157；3.J.237.166；3.J.237.169；3.J.237.172；3.J.237.175；3.J.237.240；3.J.237.244；3.J.238.228；3.J.238.229；3.J.238.230；3.J.238.231；3.J.238.236；3.J.238.237；3.J.238.238；3.J.238.239；3.J.238.154；3.J.238.157；3.J.238.166；3.J.238.169；3.J.238.172；3.J.238.175；3.J.238.240；3.J.238.244；3.J.239.228；3.J.239.229；3.J.239.230；3.J.239.231；3.J.239.236；3.J.239.237；3.J.239.238；
3.J.239.239；3.J.239.154；3.J.239.157；3.J.239.166；3.J.239.169；3.J.239.172；3.J.239.175；3.J.239.240；3.J.239.244；3.J.154.228；3.J.154.229；3.J.154.230；3.J.154.231；3.J.154.236；3.J.154.237；3.J.154.238；3.J.154.239；3.J.154.154；3.J.154.157；3.J.154.166；3.J.154.169；3.J.154.172；3.J.154.175；3.J.154.240；3.J.154.244；3.J.157.228；3.J.157.229；3.J.157.230；3.J.157.231；3.J.157.236；3.J.157.237；3.J.157.238；3.J.157.239；3.J.157.154；3.J.157.157；3.J.157.166；3.J.157.169；3.J.157.172；3.J.157.175；3.J.157.240；3.J.157.244；3.J.166.228；3.J.166.229；3.J.166.230；3.J.166.231；3.J.166.236；3.J.166.237；3.J.166.238；3.J.166.239；3.J.166.154；3.J.166.157；3.J.166.166；3.J.166.169；3.J.166.172；3.J.166.175；3.J.166.240；3.J.166.244；3.J.169.228；3.J.169.229；3.J.169.230；3.J.169.231；3.J.169.236；3.J.169.237；3.J.169.238；3.J.169.239；3.J.169.154；3.J.169.157；3.J.169.166；3.J.169.169；3.J.169.172；3.J.169.175；3.J.169.240；3.J.169.244；3.J.172.228；3.J.172.229；3.J.172.230；3.J.172.231；3.J.172.236；3.J.172.237；3.J.172.238；3.J.172.239；3.J.172.154；3.J.172.157；3.J.172.166；3.J.172.169；3.J.172.172；3.J.172.175；3.J.172.240；3.J.172.244；3.J.175.228；3.J.175.229；3.J.175.230；3.J.175.231；3.J.175.236；3.J.175.237；3.J.175.238；3.J.175.239；3.J.175.154；3.J.175.157；3.J.175.166；3.J.175.169；3.J.175.172；3.J.175.175；3.J.175.240；3.J.175.244；3.J.240.228；3.J.240.229；3.J.240.230；3.J.240.231；3.J.240.236；3.J.240.237；3.J.240.238；3.J.240.239；3.J.240.154；3.J.240.157；3.J.240.166；3.J.240.169；3.J.240.172；3.J.240.175；3.J.240.240；3.J.240.244；3.J.244.228；3.J.244.229；3.J.244.230；3.J.244.231；3.J.244.236；3.J.244.237；3.J.244.238；3.J.244.239；3.J.244.154；3.J.244.157；3.J.244.166；3.J.244.169；3.J.244.172；3.J.244.175；3.J.244.240；3.J.244.244；3.L的前體藥物3.L.228.228；3.L.228.229；3.L.228.230；3.L.228.231；3.L.228.236；3.L.228.237；3.L.228.238；3.L.228.239；3.L.228.154；3.L.228.157；3.L.228.166；3.L.228.169；3.L.228.172；3.L.228.175；3.L.228.240；3.L.228.244；3.L.229.228；3.L.229.229；3.L.229.230；3.L.229.231；3.L.229.236；3.L.229.237；3.L.229.238；3.L.229.239；3.L.229.154；3.L.229.157；3.L.229.166；3.L.229.169；3.L.229.172；3.L.229.175；3.L.229.240；3.L.229.244；3.L.230.228；3.L.230.229；3.L.230.230；3.L.230.231；3.L.230.236；3.L.230.237；3.L.230.238；3.L.230.239；3.L.230.154；3.L.230.157；3.L.230.166；3.L.230.169；3.L.230.172；3.L.230.175；3.L.230.240；3.L.230.244；3.L.231.228；3.L.231.229；3.L.231.230；3.L.231.231；3.L.231.236；3.L.231.237；3.L.231.238；3.L.231.239；3.L.231.154；3.L.231.157；3.L.231.166；3.L.231.169；3.L.231.172；3.L.231.175；3.L.231.240；3.L.231.244；3.L.236.228；3.L.236.229；3.L.236.230；3.L.236.231；3.L.236.236；3.L.236.237；3.L.236.238；3.L.236.239；3.L.236.154；3.L.236.157；3.L.236.166；3.L.236.169；3.L.236.172；3.L.236.175；3.L.236.240；3.L.236.244；3.L.237.228；3.L.237.229；3.L.237.230；3.L.237.231；3.L.237.236；3.L.237.237；3.L.237.238；3.L.237.239；3.L.237.154；3.L.237.157；3.L.237.166；3.L.237.169；3.L.237.172；3.L.237.175；3.L.237.240；3.L.237.244；3.L.238.228；3.L.238.229；3.L.238.230；3.L.238.231；3.L.238.236；3.L.238.237；3.L.238.238；3.L.238.239；3.L.238.154；3.L.238.157；3.L.238.166；3.L.238.169；3.L.238.172；3.L.238.175；3.L.238.240；3.L.238.244；3.L.239.228；3.L.239.229；3.L.239.230；3.L.239.231；3.L.239.236；3.L.239.237；3.L.239.238；3.L.239.239；3.L.239.154；3.L.239.157；3.L.239.166；3.L.239.169；3.L.239.172；3.L.239.175；3.L.239.240；3.L.239.244；3.L.154.228；3.L.154.229；3.L.154.230；3.L.154.231；3.L.154.236；3.L.154.237；3.L.154.238；3.L.154.239；3.L.154.154；3.L.154.157；3.L.154.166；3.L.154.169；3.L.154.172；3.L.154.175；3.L.154.240；3.L.154.244；
3.L.157.228；3.L.157.229；3.L.157.230；3.L.157.231；3.L.157.236；3.L.157.237；3.L.157.238；3.L.157.239；3.L.157.154；3.L.157.157；3.L.157.166；3.L.157.169；3.L.157.172；3.L.157.175；3.L.157.240；3.L.157.244；3.L.166.228；3.L.166.229；3.L.166.230；3.L.166.231；3.L.166.236；3.L.166.237；3.L.166.238；3.L.166.239；3.L.166.154；3.L.166.157；3.L.166.166；3.L.166.169；3.L.166.172；3.L.166.175；3.L.166.240；3.L.166.244；3.L.169.228；3.L.169.229；3.L.169.230；3.L.169.231；3.L.169.236；3.L.169.237；3.L.169.238；3.L.169.239；3.L.169.154；3.L.169.157；3.L.169.166；3.L.169.169；3.L.169.172；3.L.169.175；3.L.169.240；3.L.169.244；3.L.172.228；3.L.172.229；3.L.172.230；3.L.172.231；3.L.172.236；3.L.172.237；3.L.172.238；3.L.172.239；3.L.172.154；3.L.172.157；3.L.172.166；3.L.172.169；3.L.172.172；3.L.172.175；3.L.172.240；3.L.172.244；3.L.175.228；3.L.175.229；3.L.175.230；3.L.175.231；3.L.175.236；3.L.175.237；3.L.175.238；3.L.175.239；3.L.175.154；3.L.175.157；3.L.175.166；3.L.175.169；3.L.175.172；3.L.175.175；3.L.175.240；3.L.175.244；3.L.240.228；3.L.240.229；3.L.240.230；3.L.240.231；3.L.240.236；3.L.240.237；3.L.240.238；3.L.240.239；3.L.240.154；3.L.240.157；3.L.240.166；3.L.240.169；3.L.240.172；3.L.240.175；3.L.240.240；3.L.240.244；3.L.244.228；3.L.244.229；3.L.244.230；3.L.244.231；3.L.244.236；3.L.244.237；3.L.244.238；3.L.244.239；3.L.244.154；3.L.244.157；3.L.244.166；3.L.244.169；3.L.244.172；3.L.244.175；3.L.244.240；3.L.244.244；3.O的前體藥物3.O.228.228；3.O.228.229；3.O.228.230；3.O.228.231；3.O.228.236；3.O.228.237；3.O.228.238；3.O.228.239；3.O.228.154；3.O.228.157；3.O.228.166；3.O.228.169；3.O.228.172；3.O.228.175；3.O.228.240；3.O.228.244；3.O.229.228；3.O.229.229；3.O.229.230；3.O.229.231；3.O.229.236；3.O.229.237；3.O.229.238；3.O.229.239；3.O.229.154；3.O.229.157；3.O.229.166；3.O.229.169；3.O.229.172；3.O.229.175；3.O.229.240；3.O.229.244；3.O.230.228；3.O.230.229；3.O.230.230；3.O.230.231；3.O.230.236；3.O.230.237；3.O.230.238；3.O.230.239；3.O.230.154；3.O.230.157；3.O.230.166；3.O.230.169；3.O.230.172；3.O.230.175；3.O.230.240；3.O.230.244；3.O.231.228；3.O.231.229；3.O.231.230；3.O.231.231；3.O.231.236；3.O.231.237；3.O.231.238；3.O.231.239；3.O.231.154；3.O.231.157；3.O.231.166；3.O.231.169；3.O.231.172；3.O.231.175；3.O.231.240；3.O.231.244；3.O.236.228；3.O.236.229；3.O.236.230；3.O.236.231；3.O.236.236；3.O.236.237；3.O.236.238；3.O.236.239；3.O.236.154；3.O.236.157；3.O.236.166；3.O.236.169；3.O.236.172；3.O.236.175；3.O.236.240；3.O.236.244；3.O.237.228；3.O.237.229；3.O.237.230；3.O.237.231；3.O.237.236；3.O.237.237；3.O.237.238；3.O.237.239；3.O.237.154；3.O.237.157；3.O.237.166；3.O.237.169；3.O.237.172；3.O.237.175；3.O.237.240；3.O.237.244；3.O.238.228；3.O.238.229；3.O.238.230；3.O.238.231；3.O.238.236；3.O.238.237；3.O.238.238；3.O.238.239；3.O.238.154；3.O.238.157；3.O.238.166；3.O.238.169；3.O.238.172；3.O.238.175；3.O.238.240；3.O.238.244；3.O.239.228；3.O.239.229；3.O.239.230；3.O.239.231；3.O.239.236；3.O.239.237；3.O.239.238；3.O.239.239；3.O.239.154；3.O.239.157；3.O.239.166；3.O.239.169；3.O.239.172；3.O.239.175；3.O.239.240；3.O.239.244；3.O.154.228；3.O.154.229；3.O.154.230；3.O.154.231；3.O.154.236；3.O.154.237；3.O.154.238；3.O.154.239；3.O.154.154；3.O.154.157；3.O.154.166；3.O.154.169；3.O.154.172；3.O.154.175；3.O.154.240；3.O.154.244；3.O.157.228；3.O.157.229；3.O.157.230；3.O.157.231；3.O.157.236；3.O.157.237；
3.O.157.238；3.O.157.239；3.O.157.154；3.O.157.157；3.O.157.166；3.O.157.169；3.O.157.172；3.O.157.175；3.O.157.240；3.O.157.244；3.O.166.228；3.O.166.229；3.O.166.230；3.O.166.231；3.O.166.236；3.O.166.237；3.O.166.238；3.O.166.239；3.O.166.154；3.O.166.157；3.O.166.166；3.O.166.169；3.O.166.172；3.O.166.175；3.O.166.240；3.O.166.244；3.O.169.228；3.O.169.229；3.O.169.230；3.O.169.231；3.O.169.236；3.O.169.237；3.O.169.238；3.O.169.239；3.O.169.154；3.O.169.157；3.O.169.166；3.O.169.169；3.O.169.172；3.O.169.175；3.O.169.240；3.O.169.244；3.O.172.228；3.O.172.229；3.O.172.230；3.O.172.231；3.O.172.236；3.O.172.237；3.O.172.238；3.O.172.239；3.O.172.154；3.O.172.157；3.O.172.166；3.O.172.169；3.O.172.172；3.O.172.175；3.O.172.240；3.O.172.244；3.O.175.228；3.O.175.229；3.O.175.230；3.O.175.231；3.O.175.236；3.O.175.237；3.O.175.238；3.O.175.239；3.O.175.154；3.O.175.157；3.O.175.166；3.O.175.169；3.O.175.172；3.O.175.175；3.O.175.240；3.O.175.244；3.O.240.228；3.O.240.229；3.O.240.230；3.O.240.231；3.O.240.236；3.O.240.237；3.O.240.238；3.O.240.239；3.O.240.154；3.O.240.157；3.O.240.166；3.O.240.169；3.O.240.172；3.O.240.175；3.O.240.240；3.O.240.244；3.O.244.228；3.O.244.229；3.O.244.230；3.O.244.231；3.O.244.236；3.O.244.237；3.O.244.238；3.O.244.239；3.O.244.154；3.O.244.157；3.O.244.166；3.O.244.169；3.O.244.172；3.O.244.175；3.O.244.240；3.O.244.244；3.P的前體藥物3.P.228.228；3.P.228.229；3.P.228.230；3.P.228.231；3.P.228.236；3.P.228.237；3.P.228.238；3.P.228.239；3.P.228.154；3.P.228.157；3.P.228.166；3.P.228.169；3.P.228.172；3.P.228.175；3.P.228.240；3.P.228.244；3.P.229.228；3.P.229.229；3.P.229.230；3.P.229.231；3.P.229.236；3.P.229.237；3.P.229.238；3.P.229.239；3.P.229.154；3.P.229.157；3.P.229.166；3.P.229.169；3.P.229.172；3.P.229.175；3.P.229.240；3.P.229.244；3.P.230.228；3.P.230.229；3.P.230.230；3.P.230.231；3.P.230.236；3.P.230.237；3.P.230.238；3.P.230.239；3.P.230.154；3.P.230.157；3.P.230.166；3.P.230.169；3.P.230.172；3.P.230.175；3.P.230.240；3.P.230.244；3.P.231.228；3.P.231.229；3.P.231.230；3.P.231.231；3.P.231.236；3.P.231.237；3.P.231.238；3.P.231.239；3.P.231.154；3.P.231.157；3.P.231.166；3.P.231.169；3.P.231.172；3.P.231.175；3.P.231.240；3.P.231.244；3.P.236.228；3.P.236.229；3.P.236.230；3.P.236.231；3.P.236.236；3.P.236.237；3.P.236.238；3.P.236.239；3.P.236.154；3.P.236.157；3.P.236.166；3.P.236.169；3.P.236.172；3.P.236.175；3.P.236.240；3.P.236.244；3.P.237.228；3.P.237.229；3.P.237.230；3.P.237.231；3.P.237.236；3.P.237.237；3.P.237.238；3.P.237.239；3.P.237.154；3.P.237.157；3.P.237.166；3.P.237.169；3.P.237.172；3.P.237.175；3.P.237.240；3.P.237.244；3.P.238.228；3.P.238.229；3.P.238.230；3.P.238.231；3.P.238.236；3.P.238.237；3.P.238.238；3.P.238.239；3.P.238.154；3.P.238.157；3.P.238.166；3.P.238.169；3.P.238.172；3.P.238.175；3.P.238.240；3.P.238.244；3.P.239.228；3.P.239.229；3.P.239.230；3.P.239.231；3.P.239.236；3.P.239.237；3.P.239.238；3.P.239.239；3.P.239.154；3.P.239.157；3.P.239.166；3.P.239.169；3.P.239.172；3.P.239.175；3.P.239.240；3.P.239.244；3.P.154.228；3.P.154.229；3.P.154.230；3.P.154.231；3.P.154.236；3.P.154.237；3.P.154.238；3.P.154.239；3.P.154.154；3.P.154.157；3.P.154.166；3.P.154.169；3.P.154.172；3.P.154.175；3.P.154.240；3.P.154.244；3.P.157.228；3.P.157.229；3.P.157.230；3.P.157.231；3.P.157.236；3.P.157.237；3.P.157.238；3.P.157.239；3.P.157.154；3.P.157.157；3.P.157.166；3.P.157.169；3.P.157.172；3.P.157.175；3.P.157.240；3.P.157.244；3.P.166.228；3.P.166.229；3.P.166.230；3.P.166.231；3.P.166.236；3.P.166.237；3.P.166.238；3.P.166.239；3.P.166.154；3.P.166.157；3.P.166.166；3.P.166.169；3.P.166.172；3.P.166.175；3.P.166.240；3.P.166.244；3.P.169.228；3.P.169.229；3.P.169.230；3.P.169.231；3.P.169.236；
3.P.169.237；3.P.169.238；3.P.169.239；3.P.169.154；3.P.169.157；3.P.169.166；3.P.169.169；3.P.169.172；3.P.169.175；3.P.169.240；3.P.169.244；3.P.172.228；3.P.172.229；3.P.172.230；3.P.172.231；3.P.172.236；3.P.172.237；3.P.172.238；3.P.172.239；3.P.172.154；3.P.172.157；3.P.172.166；3.P.172.169；3.P.172.172；3.P.172.175；3.P.172.240；3.P.172.244；3.P.175.228；3.P.175.229；3.P.175.230；3.P.175.231；3.P.175.236；3.P.175.237；3.P.175.238；3.P.175.239；3.P.175.154；3.P.175.157；3.P.175.166；3.P.175.169；3.P.175.172；3.P.175.175；3.P.175.240；3.P.175.244；3.P.240.228；3.P.240.229；3.P.240.230；3.P.240.231；3.P.240.236；3.P.240.237；3.P.240.238；3.P.240.239；3.P.240.154；3.P.240.157；3.P.240.166；3.P.240.169；3.P.240.172；3.P.240.175；3.P.240.240；3.P.240.244；3.P.244.228；3.P.244.229；3.P.244.230；3.P.244.231；3.P.244.236；3.P.244.237；3.P.244.238；3.P.244.239；3.P.244.154；3.P.244.157；3.P.244.166；3.P.244.169；3.P.244.172；3.P.244.175；3.P.244.240；3.P.244.244；3.U的前體藥物3.U.228.228；3.U.228.229；3.U.228.230；3.U.228.231；3.U.228.236；3.U.228.237；3.U.228.238；3.U.228.239；3.U.228.154；3.U.228.157；3.U.228.166；3.U.228.169；3.U.228.172；3.U.228.175；3.U.228.240；3.U.228.244；3.U.229.228；3.U.229.229；3.U.229.230；3.U.229.231；3.U.229.236；3.U.229.237；3.U.229.238；3.U.229.239；3.U.229.154；3.U.229.157；3.U.229.166；3.U.229.169；3.U.229.172；3.U.229.175；3.U.229.240；3.U.229.244；3.U.230.228；3.U.230.229；3.U.230.230；3.U.230.231；3.U.230.236；3.U.230.237；3.U.230.238；3.U.230.239；3.U.230.154；3.U.230.157；3.U.230.166；3.U.230.169；3.U.230.172；3.U.230.175；3.U.230.240；3.U.230.244；3.U.231.228；3.U.231.229；3.U.231.230；3.U.231.231；3.U.231.236；3.U.231.237；3.U.231.238；3.U.231.239；3.U.231.154；3.U.231.157；3.U.231.166；3.U.231.169；3.U.231.172；3.U.231.175；3.U.231.240；3.U.231.244；3.U.236.228；3.U.236.229；3.U.236.230；3.U.236.231；3.U.236.236；3.U.236.237；3.U.236.238；3.U.236.239；3.U.236.154；3.U.236.157；3.U.236.166；3.U.236.169；3.U.236.172；3.U.236.175；3.U.236.240；3.U.236.244；3.U.237.228；3.U.237.229；3.U.237.230；3.U.237.231；3.U.237.236；3.U.237.237；3.U.237.238；3.U.237.239；3.U.237.154；3.U.237.157；3.U.237.166；3.U.237.169；3.U.237.172；3.U.237.175；3.U.237.240；3.U.237.244；3.U.238.228；3.U.238.229；3.U.238.230；3.U.238.231；3.U.238.236；3.U.238.237；3.U.238.238；3.U.238.239；3.U.238.154；3.U.238.157；3.U.238.166；3.U.238.169；3.U.238.172；3.U.238.175；3.U.238.240；3.U.238.244；3.U.239.228；3.U.239.229；3.U.239.230；3.U.239.231；3.U.239.236；3.U.239.237；3.U.239.238；3.U.239.239；3.U.239.154；3.U.239.157；3.U.239.166；3.U.239.169；3.U.239.172；3.U.239.175；3.U.239.240；3.U.239.244；3.U.154.228；3.U.154.229；3.U.154.230；3.U.154.231；3.U.154.236；3.U.154.237；3.U.154.238；3.U.154.239；3.U.154.154；3.U.154.157；3.U.154.166；3.U.154.169；3.U.154.172；3.U.154.175；3.U.154.240；3.U.154.244；3.U.157.228；3.U.157.229；3.U.157.230；3.U.157.231；3.U.157.236；3.U.157.237；3.U.157.238；3.U.157.239；3.U.157.154；3.U.157.157；3.U.157.166；3.U.157.169；3.U.157.172；3.U.157.175；3.U.157.240；3.U.157.244；3.U.166.228；3.U.166.229；3.U.166.230；3.U.166.231；3.U.166.236；3.U.166.237；3.U.166.238；3.U.166.239；3.U.166.154；3.U.166.157；3.U.166.166；3.U.166.169；3.U.166.172；3.U.166.175；3.U.166.240；3.U.166.244；3.U.169.228；3.U.169.229；3.U.169.230；3.U.169.231；3.U.169.236；3.U.169.237；3.U.169.238；3.U.169.239；3.U.169.154；3.U.169.157；3.U.169.166；3.U.169.169；3.U.169.172；3.U.169.175；3.U.169.240；3.U.169.244；3.U.172.228；3.U.172.229；3.U.172.230；3.U.172.231；3.U.172.236；3.U.172.237；
3.U.172.238；3.U.172.239；3.U.172.154；3.U.172.157；3.U.172.166；3.U.172.169；3.U.172.172；3.U.172.175；3.U.172.240；3.U.172.244；3.U.175.228；3.U.175.229；3.U.175.230；3.U.175.231；3.U.175.236；3.U.175.237；3.U.175.238；3.U.175.239；3.U.175.154；3.U.175.157；3.U.175.166；3.U.175.169；3.U.175.172；3.U.175.175；3.U.175.240；3.U.175.244；3.U.240.228；3.U.240.229；3.U.240.230；3.U.240.231；3.U.240.236；3.U.240.237；3.U.240.238；3.U.240.239；3.U.240.154；3.U.240.157；3.U.240.166；3.U.240.169；3.U.240.172；3.U.240.175；3.U.240.240；3.U.240.244；3.U.244.228；3.U.244.229；3.U.244.230；3.U.244.231；3.U.244.236；3.U.244.237；3.U.244.238；3.U.244.239；3.U.244.154；3.U.244.157；3.U.244.166；3.U.244.169；3.U.244.172；3.U.244.175；3.U.244.240；3.U.244.244；3.W的前體藥物3.W.228.228；3.W.228.229；3.W.228.230；3.W.228.231；3.W.228.236；3.W.228.237；3.W.228.238；3.W.228.239；3.W.228.154；3.W.228.157；3.W.228.166；3.W.228.169；3.W.228.172；3.W.228.175；3.W.228.240；3.W.228.244；3.W.229.228；3.W.229.229；3.W.229.230；3.W.229.231；3.W.229.236；3.W.229.237；3.W.229.238；3.W.229.239；3.W.229.154；3.W.229.157；3.W.229.166；3.W.229.169；3.W.229.172；3.W.229.175；3.W.229.240；3.W.229.244；3.W.230.228；3.W.230.229；3.W.230.230；3.W.230.231；3.W.230.236；3.W.230.237；3.W.230.238；3.W.230.239；3.W.230.154；3.W.230.157；3.W.230.166；3.W.230.169；3.W.230.172；3.W.230.175；3.W.230.240；3.W.230.244；3.W.231.228；3.W.231.229；3.W.231.230；3.W.231.231；3.W.231.236；3.W.231.237；3.W.231.238；3.W.231.239；3.W.231.154；3.W.231.157；3.W.231.166；3.W.231.169；3.W.231.172；3.W.231.175；3.W.231.240；3.W.231.244；3.W.236.228；3.W.236.229；3.W.236.230；3.W.236.231；3.W.236.236；3.W.236.237；3.W.236.238；3.W.236.239；3.W.236.154；3.W.236.157；3.W.236.166；3.W.236.169；3.W.236.172；3.W.236.175；3.W.236.240；3.W.236.244；3.W.237.228；3.W.237.229；3.W.237.230；3.W.237.231；3.W.237.236；3.W.237.237；3.W.237.238；3.W.237.239；3.W.237.154；3.W.237.157；3.W.237.166；3.W.237.169；3.W.237.172；3.W.237.175；3.W.237.240；3.W.237.244；3.W.238.228；3.W.238.229；3.W.238.230；3.W.238.231；3.W.238.236；3.W.238.237；3.W.238.238；3.W.238.239；3.W.238.154；3.W.238.157；3.W.238.166；3.W.238.169；3.W.238.172；3.W.238.175；3.W.238.240；3.W.238.244；3.W.239.228；3.W.239.229；3.W.239.230；3.W.239.231；3.W.239.236；3.W.239.237；3.W.239.238；3.W.239.239；3.W.239.154；3.W.239.157；3.W.239.166；3.W.239.169；3.W.239.172；3.W.239.175；3.W.239.240；3.W.239.244；3.W.154.228；3.W.154.229；3.W.154.230；3.W.154.231；3.W.154.236；3.W.154.237；3.W.154.238；3.W.154.239；3.W.154.154；3.W.154.157；3.W.154.166；3.W.154.169；3.W.154.172；3.W.154.175；3.W.154.240；3.W.154.244；3.W.157.228；3.W.157.229；3.W.157.230；3.W.157.231；3.W.157.236；3.W.157.237；3.W.157.238；3.W.157.239；3.W.157.154；3.W.157.157；3.W.157.166；3.W.157.169；3.W.157.172；3.W.157.175；3.W.157.240；3.W.157.244；3.W.166.228；3.W.166.229；3.W.166.230；3.W.166.231；3.W.166.236；3.W.166.237；3.W.166.238；3.W.166.239；3.W.166.154；3.W.166.157；3.W.166.166；3.W.166.169；3.W.166.172；3.W.166.175；3.W.166.240；3.W.166.244；3.W.169.228；3.W.169.229；3.W.169.230；3.W.169.231；3.W.169.236；3.W.169.237；3.W.169.238；3.W.169.239；3.W.169.154；3.W.169.157；3.W.169.166；3.W.169.169；3.W.169.172；3.W.169.175；3.W.169.240；3.W.169.244；3.W.172.228；3.W.172.229；3.W.172.230；3.W.172.231；3.W.172.236；3.W.172.237；3.W.172.238；3.W.172.239；3.W.172.154；3.W.172.157；3.W.172.166；3.W.172.169；
3.W.172.172；3.W.172.175；3.W.172.240；3.W.172.244；3.W.175.228；3.W.175.229；3.W.175.230；3.W.175.231；3.W.175.236；3.W.175.237；3.W.175.238；3.W.175.239；3.W.175.154；3.W.175.157；3.W.175.166；3.W.175.169；3.W.175.172；3.W.175.175；3.W.175.240；3.W.175.244；3.W.240.228；3.W.240.229；3.W.240.230；3.W.240.231；3.W.240.236；3.W.240.237；3.W.240.238；3.W.240.239；3.W.240.154；3.W.240.157；3.W.240.166；3.W.240.169；3.W.240.172；3.W.240.175；3.W.240.240；3.W.240.244；3.W.244.228；3.W.244.229；3.W.244.230；3.W.244.231；3.W.244.236；3.W.244.237；3.W.244.238；3.W.244.239；3.W.244.154；3.W.244.157；3.W.244.166；3.W.244.169；3.W.244.172；3.W.244.175；3.W.244.240；3.W.244.244；3.Y的前體藥物3.Y.228.228；3.Y.228.229；3.Y.228.230；3.Y.228.231；3.Y.228.236；3.Y.228.237；3.Y.228.238；3.Y.228.239；3.Y.228.154；3.Y.228.157；3.Y.228.166；3.Y.228.169；3.Y.228.172；3.Y.228.175；3.Y.228.240；3.Y.228.244；3.Y.229.228；3.Y.229.229；3.Y.229.230；3.Y.229.231；3.Y.229.236；3.Y.229.237；3.Y.229.238；3.Y.229.239；3.Y.229.154；3.Y.229.157；3.Y.229.166；3.Y.229.169；3.Y.229.172；3.Y.229.175；3.Y.229.240；3.Y.229.244；3.Y.230.228；3.Y.230.229；3.Y.230.230；3.Y.230.231；3.Y.230.236；3.Y.230.237；3.Y.230.238；3.Y.230.239；3.Y.230.154；3.Y.230.157；3.Y.230.166；3.Y.230.169；3.Y.230.172；3.Y.230.175；3.Y.230.240；3.Y.230.244；3.Y.231.228；3.Y.231.229；3.Y.231.230；3.Y.231.231；3.Y.231.236；3.Y.231.237；3.Y.231.238；3.Y.231.239；3.Y.231.154；3.Y.231.157；3.Y.231.166；3.Y.231.169；3.Y.231.172；3.Y.231.175；3.Y.231.240；3.Y.231.244；3.Y.236.228；3.Y.236.229；3.Y.236.230；3.Y.236.231；3.Y.236.236；3.Y.236.237；3.Y.236.238；3.Y.236.239；3.Y.236.154；3.Y.236.157；3.Y.236.166；3.Y.236.169；3.Y.236.172；3.Y.236.175；3.Y.236.240；3.Y.236.244；3.Y.237.228；3.Y.237.229；3.Y.237.230；3.Y.237.231；3.Y.237.236；3.Y.237.237；3.Y.237.238；3.Y.237.239；3.Y.237.154；3.Y.237.157；3.Y.237.166；3.Y.237.169；3.Y.237.172；3.Y.237.175；3.Y.237.240；3.Y.237.244；3.Y.238.228；3.Y.238.229；3.Y.238.230；3.Y.238.231；3.Y.238.236；3.Y.238.237；3.Y.238.238；3.Y.238.239；3.Y.238.154；3.Y.238.157；3.Y.238.166；3.Y.238.169；3.Y.238.172；3.Y.238.175；3.Y.238.240；3.Y.238.244；3.Y.239.228；3.Y.239.229；3.Y.239.230；3.Y.239.231；3.Y.239.236；3.Y.239.237；3.Y.239.238；3.Y.239.239；3.Y.239.154；3.Y.239.157；3.Y.239.166；3.Y.239.169；3.Y.239.172；3.Y.239.175；3.Y.239.240；3.Y.239.244；3.Y.154.228；3.Y.154.229；3.Y.154.230；3.Y.154.231；3.Y.154.236；3.Y.154.237；3.Y.154.238；3.Y.154.239；3.Y.154.154；3.Y.154.157；3.Y.154.166；3.Y.154.169；3.Y.154.172；3.Y.154.175；3.Y.154.240；3.Y.154.244；3.Y.157.228；3.Y.157.229；3.Y.157.230；3.Y.157.231；3.Y.157.236；3.Y.157.237；3.Y.157.238；3.Y.157.239；3.Y.157.154；3.Y.157.157；3.Y.157.166；3.Y.157.169；3.Y.157.172；3.Y.157.175；3.Y.157.240；3.Y.157.244；3.Y.166.228；3.Y.166.229；3.Y.166.230；3.Y.166.231；3.Y.166.236；3.Y.166.237；3.Y.166.238；3.Y.166.2.39；3.Y.166.154；3.Y.166.157；3.Y.166.166；3.Y.166.169；3.Y.166.172；3.Y.166.175；3.Y.166.240；3.Y.166.244；3.Y.169.228；3.Y.169.229；3.Y.169.230；3.Y.169.231；3.Y.169.236；3.Y.169.237；3.Y.169.238；3.Y.169.239；3.Y.169.154；3.Y.169.157；3.Y.169.166；3.Y.169.169；3.Y.169.172；3.Y.169.175；3.Y.169.240；3.Y.169.244；3.Y.172.228；3.Y.172.229；3.Y.172.230；3.Y.172.231；3.Y.172.236；3.Y.172.237；3.Y.172.238；3.Y.172.239；3.Y.172.154；3.Y.172.157；3.Y.172.166；3.Y.172.169；3.Y.172.172；3.Y.172.175；3.Y.172.240；3.Y.172.244；3.Y.175.228；3.Y.175.229；
3.Y.175.230；3.Y.175.231；3.Y.175.236；3.Y.175.237；3.Y.175.238；3.Y.175.239；3.Y.175.154；3.Y.175.157；3.Y.175.166；3.Y.175.169；3.Y.175.172；3.Y.175.175；3.Y.175.240；3.Y.175.244；3.Y.240.228；3.Y.240.229；3.Y.240.230；3.Y.240.231；3.Y.240.236；3.Y.240.237；3.Y.240.238；3.Y.240.239；3.Y.240.154；3.Y.240.157；3.Y.240.166；3.Y.240.169；3.Y.240.172；3.Y.240.175；3.Y.240.240；3.Y.240.244；3.Y.244.228；3.Y.244.229；3.Y.244.230；3.Y.244.231；3.Y.244.236；3.Y.244.237；3.Y.244.238；3.Y.244.239；3.Y.244.154；3.Y.244.157；3.Y.244.166；3.Y.244.169；3.Y.244.172；3.Y.244.175；3.Y.244.240；3.Y.244.244；4.B的前體藥物4.B.228.228；4.B.228.229；4.B.228.230；4.B.228.231；4.B.228.236；4.B.228.237；4.B.228.238；4.B.228.239；4.B.228.154；4.B.228.157；4.B.228.166；4.B.228.169；4.B.228.172；4.B.228.175；4.B.228.240；4.B.228.244；4.B.229.228；4.B.229.229；4.B.229.230；4.B.229.231；4.B.229.236；4.B.229.237；4.B.229.238；4.B.229.239；4.B.229.154；4.B.229.157；4.B.229.166；4.B.229.169；4.B.229.172；4.B.229.175；4.B.229.240；4.B.229.244；4.B.230.228；4.B.230.229；4.B.230.230；4.B.230.231；4.B.230.236；4.B.230.237；4.B.230.238；4.B.230.239；4.B.230.154；4.B.230.157；4.B.230.166；4.B.230.169；4.B.230.172；4.B.230.175；4.B.230.240；4.B.230.244；4.B.231.228；4.B.231.229；4.B.231.230；4.B.231.231；4.B.231.236；4.B.231.237；4.B.231.238；4.B.231.239；4.B.231.154；4.B.231.157；4.B.231.166；4.B.231.169；4.B.231.172；4.B.231.175；4.B.231.240；4.B.231.244；4.B.236.228；4.B.236.229；4.B.236.230；4.B.236.231；4.B.236.236；4.B.236.237；4.B.236.238；4.B.236.239；4.B.236.154；4.B.236.157；4.B.236.166；4.B.236.169；4.B.236.172；4.B.236.175；4.B.236.240；4.B.236.244；4.B.237.228；4.B.237.229；4.B.237.230；4.B.237.231；4.B.237.236；4.B.237.237；4.B.237.238；4.B.237.239；4.B.237.154；4.B.237.157；4.B.237.166；4.B.237.169；4.B.237.172；4.B.237.175；4.B.237.240；4.B.237.244；4.B.238.228；4.B.238.229；4.B.238.230；4.B.238.231；4.B.238.236；4.B.238.237；4.B.238.238；4.B.238.239；4.B.238.154；4.B.238.157；4.B.238.166；4.B.238.169；4.B.238.172；4.B.238.175；4.B.238.240；4.B.238.244；4.B.239.228；4.B.239.229；4.B.239.230；4.B.239.231；4.B.239.236；4.B.239.237；4.B.239.238；4.B.239.239；4.B.239.154；4.B.239.157；4.B.239.166；4.B.239.169；4.B.239.172；4.B.239.175；4.B.239.240；4.B.239.244；4.B.154.228；4.B.154.229；4.B.154.230；4.B.154.231；4.B.154.236；4.B.154.237；4.B.154.238；4.B.154.239；4.B.154.154；4.B.154.157；4.B.154.166；4.B.154.169；4.B.154.172；4.B.154.175；4.B.154.240；4.B.154.244；4.B.157.228；4.B.157.229；4.B.157.230；4.B.157.231；4.B.157.236；4.B.157.237；4.B.157.238；4.B.157.239；4.B.157.154；4.B.157.157；4.B.157.166；4.B.157.169；4.B.157.172；4.B.157.175；4.B.157.240；4.B.157.244；4.B.166.228；4.B.166.229；4.B.166.230；4.B.166.231；4.B.166.236；4.B.166.237；4.B.166.238；4.B.166.239；4.B.166.154；4.B.166.157；4.B.166.166；4.B.166.169；4.B.166.172；4.B.166.175；4.B.166.240；4.B.166.244；4.B.169.228；4.B.169.229；4.B.169.230；4.B.169.231；4.B.169.236；4.B.169.237；4.B.169.238；4.B.169.239；4.B.169.154；4.B.169.157；4.B.169.166；4.B.169.169；4.B.169.172；4.B.169.175；4.B.169.240；4.B.169.244；4.B.172.228；4.B.172.229；4.B.172.230；4.B.172.231；4.B.172.236；4.B.172.237；4.B.172.238；4.B.172.239；4.B.172.154；4.B.172.157；4.B.172.166；4.B.172.169；4.B.172.172；4.B.172.175；4.B.172.240；4.B.172.244；4.B.175.228；4.B.175.229；4.B.175.230；4.B.175.231；4.B.175.236；4.B.175.237；4.B.175.238；4.B.175.239；
4.B.175.154；4.B.175.157；4.B.175.166；4.B.175.169；4.B.175.172；4.B.175.175；4.B.175.240；4.B.175.244；4.B.240.228；4.B.240.229；4.B.240.230；4.B.240.231；4.B.240.236；4.B.240.237；4.B.240.238；4.B.240.239；4.B.240.154；4.B.240.157；4.B.240.166；4.B.240.169；4.B.240.172；4.B.240.175；4.B.240.240；4.B.240.244；4.B.244.228；4.B.244.229；4.B.244.230；4.B.244.231；4.B.244.236；4.B.244.237；4.B.244.238；4.B.244.239；4.B.244.154；4.B.244.157；4.B.244.166；4.B.244.169；4.B.244.172；4.B.244.175；4.B.244.240；4.B.244.244；4.D的前體藥物4.D.228.228；4.D.228.229；4.D.228.230；4.D.228.231；4.D.228.236；4.D.228.237；4.D.228.238；4.D.228.239；4.D.228.154；4.D.228.157；4.D.228.166；4.D.228.169；4.D.228.172；4.D.228.175；4.D.228.240；4.D.228.244；4.D.229.228；4.D.229.229；4.D.229.230；4.D.229.231；4.D.229.236；4.D.229.237；4.D.229.238；4.D.229.239；4.D.229.154；4.D.229.157；4.D.229.166；4.D.229.169；4.D.229.172；4.D.229.175；4.D.229.240；4.D.229.244；4.D.230.228；4.D.230.229；4.D.230.230；4.D.230.231；4.D.230.236；4.D.230.237；4.D.230.238；4.D.230.239；4.D.230.154；4.D.230.157；4.D.230.166；4.D.230.169；4.D.230.172；4.D.230.175；4.D.230.240；4.D.230.244；4.D.231.228；4.D.231.229；4.D.231.230；4.D.231.231；4.D.231.236；4.D.231.237；4.D.231.238；4.D.231.239；4.D.231.154；4.D.231.157；4.D.231.166；4.D.231.169；4.D.231.172；4.D.231.175；4.D.231.240；4.D.231.244；4.D.236.228；4.D.236.229；4.D.236.230；4.D.236.231；4.D.236.236；4.D.236.237；4.D.236.238；4.D.236.239；4.D.236.154；4.D.236.157；4.D.236.166；4.D.236.169；4.D.236.172；4.D.236.175；4.D.236.240；4.D.236.244；4.D.237.228；4.D.237.229；4.D.237.230；4.D.237.231；4.D.237.236；4.D.237.237；4.D.237.238；4.D.237.239；4.D.237.154；4.D.237.157；4.D.237.166；4.D.237.169；4.D.237.172；4.D.237.175；4.D.237.240；4.D.237.244；4.D.238.228；4.D.238.229；4.D.238.230；4.D.238.231；4.D.238.236；4.D.238.237；4.D.238.238；4.D.238.239；4.D.238.154；4.D.238.157；4.D.238.166；4.D.238.169；4.D.238.172；4.D.238.175；4.D.238.240；4.D.238.244；4.D.239.228；4.D.239.229；4.D.239.230；4.D.239.231；4.D.239.236；4.D.239.237；4.D.239.238；4.D.239.239；4.D.239.154；4.D.239.157；4.D.239.166；4.D.239.169；4.D.239.172；4.D.239.175；4.D.239.240；4.D.239.244；4.D.154.228；4.D.154.229；4.D.154.230；4.D.154.231；4.D.154.236；4.D.154.237；4.D.154.238；4.D.154.239；4.D.154.154；4.D.154.157；4.D.154.166；4.D.154.169；4.D.154.172；4.D.154.175；4.D.154.240；4.D.154.244；4.D.157.228；4.D.157.229；4.D.157.230；4.D.157.231；4.D.157.236；4.D.157.237；4.D.157.238；4.D.157.239；4.D.157.154；4.D.157.157；4.D.157.166；4.D.157.169；4.D.157.172；4.D.157.175；4.D.157.240；4.D.157.244；4.D.166.228；4.D.166.229；4.D.166.230；4.D.166.231；4.D.166.236；4.D.166.237；4.D.166.238；4.D.166.239；4.D.166.154；4.D.166.157；4.D.166.166；4.D.166.169；4.D.166.172；4.D.166.175；4.D.166.240；4.D.166.244；4.D.169.228；4.D.169.229；4.D.169.230；4.D.169.231；4.D.169.236；4.D.169.237；4.D.169.238；4.D.169.239；4.D.169.154；4.D.169.157；4.D.169.166；4.D.169.169；4.D.169.172；4.D.169.175；4.D.169.240；4.D.169.244；4.D.172.228；4.D.172.229；4.D.172.230；4.D.172.231；4.D.172.236；4.D.172.237；4.D.172.238；4.D.172.239；4.D.172.154；4.D.172.157；4.D.172.166；4.D.172.169；4.D.172.172；4.D.172.175；4.D.172.240；4.D.172.244；4.D.175.228；4.D.175.229；4.D.175.230；4.D.175.231；4.D.175.236；4.D.175.237；4.D.175.238；4.D.175.239；4.D.175.154；4.D.175.157；4.D.175.166；4.D.175.169；4.D.175.172；4.D.175.175；
4.D.175.240；4.D.175.244；4.D.240.228；4.D.240.229；4.D.240.230；4.D.240.231；4.D.240.236；4.D.240.237；4.D.240.238；4.D.240.239；4.D.240.154；4.D.240.157；4.D.240.166；4.D.240.169；4.D.240.172；4.D.240.175；4.D.240.240；4.D.240.244；4.D.244.228；4.D.244.229；4.D.244.230；4.D.244.231；4.D.244.236；4.D.244.237；4.D.244.238；4.D.244.239；4.D.244.154；4.D.244.157；4.D.244.166；4.D.244.169；4.D.244.172；4.D.244.175；4.D.244.240；4.D.244.244；4.E的前體藥物4.E.228.228；4.E.228.229；4.E.228.230；4.E.228.231；4.E.228.236；4.E.228.237；4.E.228.238；4.E.228.239；4.E.228.154；4.E.228.157；4.E.228.166；4.E.228.169；4.E.228.172；4.E.228.175；4.E.228.240；4.E.228.244；4.E.229.228；4.E.229.229；4.E.229.230；4.E.229.231；4.E.229.236；4.E.229.237；4.E.229.238；4.E.229.239；4.E.229.154；4.E.229.157；4.E.229.166；4.E.229.169；4.E.229.172；4.E.229.175；4.E.229.240；4.E.229.244；4.E.230.228；4.E.230.229；4.E.230.230；4.E.230.231；4.E.230.236；4.E.230.237；4.E.230.238；4.E.230.239；4.E.230.154；4.E.230.157；4.E.230.166；4.E.230.169；4.E.230.172；4.E.230.175；4.E.230.240；4.E.230.244；4.E.231.228；4.E.231.229；4.E.231.230；4.E.231.231；4.E.231.236；4.E.231.237；4.E.231.238；4.E.231.239；4.E.231.154；4.E.231.157；4.E.231.166；4.E.231.169；4.E.231.172；4.E.231.175；4.E.231.240；4.E.231.244；4.E.236.228；4.E.236.229；4.E.236.230；4.E.236.231；4.E.236.236；4.E.236.237；4.E.236.238；4.E.236.239；4.E.236.154；4.E.236.157；4.E.236.166；4.E.236.169；4.E.236.172；4.E.236.175；4.E.236.240；4.E.236.244；4.E.237.228；4.E.237.229；4.E.237.230；4.E.237.231；4.E.237.236；4.E.237.237；4.E.237.238；4.E.237.239；4.E.237.154；4.E.237.157；4.E.237.166；4.E.237.169；4.E.237.172；4.E.237.175；4.E.237.240；4.E.237.244；4.E.238.228；4.E.238.229；4.E.238.230；4.E.238.231；4.E.238.236；4.E.238.237；4.E.238.238；4.E.238.239；4.E.238.154；4.E.238.157；4.E.238.166；4.E.238.169；4.E.238.172；4.E.238.175；4.E.238.240；4.E.238.244；4.E.239.228；4.E.239.229；4.E.239.230；4.E.239.231；4.E.239.236；4.E.239.237；4.E.239.238；4.E.239.239；4.E.239.154；4.E.239.157；4.E.239.166；4.E.239.169；4.E.239.172；4.E.239.175；4.E.239.240；4.E.239.244；4.E.154.228；4.E.154.229；4.E.154.230；4.E.154.231；4.E.154.236；4.E.154.237；4.E.154.238；4.E.154.239；4.E.154.154；4.E.154.157；4.E.154.166；4.E.154.169；4.E.154.172；4.E.154.175；4.E.154.240；4.E.154.244；4.E.157.228；4.E.157.229；4.E.157.230；4.E.157.231；4.E.157.236；4.E.157.237；4.E.157.238；4.E.157.239；4.E.157.154；4.E.157.157；4.E.157.166；4.E.157.169；4.E.157.172；4.E.157.175；4.E.157.240；4.E.157.244；4.E.166.228；4.E.166.229；4.E.166.230；4.E.166.231；4.E.166.236；4.E.166.237；4.E.166.238；4.E.166.239；4.E.166.154；4.E.166.157；4.E.166.166；4.E.166.169；4.E.166.172；4.E.166.175；4.E.166.240；4.E.166.244；4.E.169.228；4.E.169.229；4.E.169.230；4.E.169.231；4.E.169.236；4.E.169.237；4.E.169.238；4.E.169.239；4.E.169.154；4.E.169.157；4.E.169.166；4.E.169.169；4.E.169.172；4.E.169.175；4.E.169.240；4.E.169.244；4.E.172.228；4.E.172.229；4.E.172.230；4.E.172.231；4.E.172.236；4.E.172.237；4.E.172.238；4.E.172.239；4.E.172.154；4.E.172.157；4.E.172.166；4.E.172.169；4.E.172.172；4.E.172.175；4.E.172.240；4.E.172.244；4.E.175.228；4.E.175.229；4.E.175.230；4.E.175.231；4.E.175.236；4.E.175.237；4.E.175.238；4.E.175.239；4.E.175.154；4.E.175.157；4.E.175.166；4.E.175.169；4.E.175.172；4.E.175.175；4.E.175.240；4.E.175.244；4.E.240.228；4.E.240.229；4.E.240.230；4.E.240.231；
4.E.240.236；4.E.240.237；4.E.240.238；4.E.240.239；4.E.240.154；4.E.240.157；4.E.240.166；4.E.240.169；4.E.240.172；4.E.240.175；4.E.240.240；4.E.240.244；4.E.244.228；4.E.244.229；4.E.244.230；4.E.244.231；4.E.244.236；4.E.244.237；4.E.244.238；4.E.244.239；4.E.244.154；4.E.244.157；4.E.244.166；4.E.244.169；4.E.244.172；4.E.244.175；4.E.244.240；4.E.244.244；4.G的前體藥物4.G.228.228；4.G.228.229；4.G.228.230；4.G.228.231；4.G.228.236；4.G.228.237；4.G.228.238；4.G.228.239；4.G.228.154；4.G.228.157；4.G.228.166；4.G.228.169；4.G.228.172；4.G.228.175；4.G.228.240；4.G.228.244；4.G.229.228；4.G.229.229；4.G.229.230；4.G.229.231；4.G.229.236；4.G.229.237；4.G.229.238；4.G.229.239；4.G.229.154；4.G.229.157；4.G.229.166；4.G.229.169；4.G.229.172；4.G.229.175；4.G.229.240；4.G.229.244；4.G.230.228；4.G.230.229；4.G.230.230；4.G.230.231；4.G.230.236；4.G.230.237；4.G.230.238；4.G.230.239；4.G.230.154；4.G.230.157；4.G.230.166；4.G.230.169；4.G.230.172；4.G.230.175；4.G.230.240；4.G.230.244；4.G.231.228；4.G.231.229；4.G.231.230；4.G.231.231；4.G.231.236；4.G.231.237；4.G.231.238；4.G.231.239；4.G.231.154；4.G.231.157；4.G.231.166；4.G.231.169；4.G.231.172；4.G.231.175；4.G.231.240；4.G.231.244；4.G.236.228；4.G.236.229；4.G.236.230；4.G.236.231；4.G.236.236；4.G.236.237；4.G.236.238；4.G.236.239；4.G.236.154；4.G.236.157；4.G.236.166；4.G.236.169；4.G.236.172；4.G.236.175；4.G.236.240；4.G.236.244；4.G.237.228；4.G.237.229；4.G.237.230；4.G.237.231；4.G.237.236；4.G.237.237；4.G.237.238；4.G.237.239；4.G.237.154；4.G.237.157；4.G.237.166；4.G.237.169；4.G.237.172；4.G.237.175；4.G.237.240；4.G.237.244；4.G.238.228；4.G.238.229；4.G.238.230；4.G.238.231；4.G.238.236；4.G.238.237；4.G.238.238；4.G.238.239；4.G.238.154；4.G.238.157；4.G.238.166；4.G.238.169；4.G.238.172；4.G.238.175；4.G.238.240；4.G.238.244；4.G.239.228；4.G.239.229；4.G.239.230；4.G.239.231；4.G.239.236；4.G.239.237；4.G.239.238；4.G.239.239；4.G.239.154；4.G.239.157；4.G.239.166；4.G.239.169；4.G.239.172；4.G.239.175；4.G.239.240；4.G.239.244；4.G.154.228；4.G.154.229；4.G.154.230；4.G.154.231；4.G.154.236；4.G.154.237；4.G.154.238；4.G.154.239；4.G.154.154；4.G.154.157；4.G.154.166；4.G.154.169；4.G.154.172；4.G.154.175；4.G.154.240；4.G.154.244；4.G.157.228；4.G.157.229；4.G.157.230；4.G.157.231；4.G.157.236；4.G.157.237；4.G.157.238；4.G.157.239；4.G.157.154；4.G.157.157；4.G.157.166；4.G.157.169；4.G.157.172；4.G.157.175；4.G.157.240；4.G.157.244；4.G.166.228；4.G.166.229；4.G.166.230；4.G.166.231；4.G.166.236；4.G.166.237；4.G.166.238；4.G.166.239；4.G.166.154；4.G.166.157；4.G.166.166；4.G.166.169；4.G.166.172；4.G.166.175；4.G.166.240；4.G.166.244；4.G.169.228；4.G.169.229；4.G.169.230；4.G.169.231；4.G.169.236；4.G.169.237；4.G.169.238；4.G.169.239；4.G.169.154；4.G.169.157；4.G.169.166；4.G.169.169；4.G.169.172；4.G.169.175；4.G.169.240；4.G.169.244；4.G.172.228；4.G.172.229；4.G.172.230；4.G.172.231；4.G.172.236；4.G.172.237；4.G.172.238；4.G.172.239；4.G.172.154；4.G.172.157；4.G.172.166；4.G.172.169；4.G.172.172；4.G.172.175；4.G.172.240；4.G.172.244；4.G.175.228；4.G.175.229；4.G.175.230；4.G.175.231；4.G.175.236；4.G.175.237；4.G.175.238；4.G.175.239；4.G.175.154；4.G.175.157；4.G.175.166；4.G.175.169；4.G.175.172；4.G.175.175；4.G.175.240；4.G.175.244；4.G.240.228；4.G.240.229；4.G.240.230；4.G.240.231；4.G.240.236；4.G.240.237；4.G.240.238；4.G.240.239；4.G.240.154；4.G.240.157；
4.G.240.166；4.G.240.169；4.G.240.172；4.G.240.175；4.G.240.240；4.G.240.244；4.G.244.228；4.G.244.229；4.G.244.230；4.G.244.231；4.G.244.236；4.G.244.237；4.G.244.238；4.G.244.239；4.G.244.154；4.G.244.157；4.G.244.166；4.G.244.169；4.G.244.172；4.G.244.175；4.G.244.240；4.G.244.244；4.I的前體藥物4.I.228.228；4.I.228.229；4.I.228.230；4.I.228.231；4.I.228.236；4.I.228.237；4.I.228.238；4.I.228.239；4.I.228.154；4.I.228.157；4.I.228.166；4.I.228.169；4.I.228.172；4.I.228.175；4.I.228.240；4.I.228.244；4.I.229.228；4.I.229.229；4.I.229.230；4.I.229.231；4.I.229.236；4.I.229.237；4.I.229.238；4.I.229.239；4.I.229.154；4.I.229.157；4.I.229.166；4.I.229.169；4.I.229.172；4.I.229.175；4.I.229.240；4.I.229.244；4.I.230.228；4.I.230.229；4.I.230.230；4.I.230.231；4.I.230.236；4.I.230.237；4.I.230.238；4.I.230.239；4.I.230.154；4.I.230.157；4.I.230.166；4.I.230.169；4.I.230.172；4.I.230.175；4.I.230.240；4.I.230.244；4.I.231.228；4.I.231.229；4.I.231.230；4.I.231.231；4.I.231.236；4.I.231.237；4.I.231.238；4.I.231.239；4.I.231.154；4.I.231.157；4.I.231.166；4.I.231.169；4.I.231.172；4.I.231.175；4.I.231.240；4.I.231.244；4.I.236.228；4.I.236.229；4.I.236.230；4.I.236.231；4.I.236.236；4.I.236.237；4.I.236.238；4.I.236.239；4.I.236.154；4.I.236.157；4.I.236.166；4.I.236.169；4.I.236.172；4.I.236.175；4.I.236.240；4.I.236.244；4.I.237.228；4.I.237.229；4.I.237.230；4.I.237.231；4.I.237.236；4.I.237.237；4.I.237.238；4.I.237.239；4.I.237.154；4.I.237.157；4.I.237.166；4.I.237.169；4.I.237.172；4.I.237.175；4.I.237.240；4.I.237.244；4.I.238.228；4.I.238.229；4.I.238.230；4.I.238.231；4.I.238.236；4.I.238.237；4.I.238.238；4.I.238.239；4.I.238.154；4.I.238.157；4.I.238.166；4.I.238.169；4.I.238.172；4.I.238.175；4.I.238.240；4.I.238.244；4.I.239.228；4.I.239.229；4.I.239.230；4.I.239.231；4.I.239.236；4.I.239.237；4.I.239.238；4.I.239.239；4.I.239.154；4.I.239.157；4.I.239.166；4.I.239.169；4.I.239.172；4.I.239.175；4.I.239.240；4.I.239.244；4.I.154.228；4.I.154.229；4.I.154.230；4.I.154.231；4.I.154.236；4.I.154.237；4.I.154.238；4.I.154.239；4.I.154.154；4.I.154.157；4.I.154.166；4.I.154.169；4.I.154.172；4.I.154.175；4.I.154.240；4.I.154.244；4.I.157.228；4.I.157.229；4.I.157.230；4.I.157.231；4.I.157.236；4.I.157.237；4.I.157.238；4.I.157.239；4.I.157.154；4.I.157.157；4.I.157.166；4.I.157.169；4.I.157.172；4.I.157.175；4.I.157.240；4.I.157.244；4.I.166.228；4.I.166.229；4.I.166.230；4.I.166.231；4.I.166.236；4.I.166.237；4.I.166.238；4.I.166.239；4.I.166.154；4.I.166.157；4.I.166.166；4.I.166.169；4.I.166.172；4.I.166.175；4.I.166.240；4.I.166.244；4.I.169.228；4.I.169.229；4.1.169.230；4.I.169.231；4.I.169.236；4.I.169.237；4.I.169.238；4.I.169.239；4.I.169.154；4.I.169.157；4.I.169.166；4.I.169.169；4.I.169.172；4.I.169.175；4.I.169.240；4.I.169.244；4.I.172.228；4.I.172.229；4.I.172.230；4.I.172.231；4.I.172.236；4.I.172.237；4.I.172.238；4.I.172.239；4.I.172.154；4.I.172.157；4.I.172.166；4.I.172.169；4.I.172.172；4.I.172.175；4.I.172.240；4.I.172.244；4.I.175.228；4.I.175.229；4.I.175.230；4.I.175.231；4.I.175.236；4.I.175.237；4.I.175.238；4.I.175.239；4.I.175.154；4.I.175.157；4.I.175.166；4.I.175.169；4.I.175.172；4.I.175.175；4.I.175.240；4.I.175.244；4.I.240.228；4.I.240.229；4.I.240.230；4.I.240.231；4.I.240.236；4.I.240.237；4.I.240.238；4.I.240.239；4.I.240.154；4.I.240.157；4.I.240.166；4.I.240.169；4.I.240.172；4.I.240.175；4.I.240.240；4.I.240.244；4.I.244.228；4.I.244.229；4.I.244.230；4.I.244.231；4.I.244.236；4.I.244.237；4.I.244.238；4.I.244.239；4.I.244.154；4.I.244.157；4.I.244.166；4.I.244.169；4.I.244.172；4.I.244.175；4.I.244.240；4.I.244.244；4.J的前體藥物
4.J.228.228；4.J.228.229；4.J.228.230；4.J.228.231；4.J.228.236；4.J.228.237；4.J.228.238；4.J.228.239；4.J.228.154；4.J.228.157；4.J.228.166；4.J.228.169；4.J.228.172；4.J.228.175；4.J.228.240；4.J.228.244；4.J.229.228；4.J.229.229；4.J.229.230；4.J.229.231；4.J.229.236；4.J.229.237；4.J.229.238；4.J.229.239；4.J.229.154；4.J.229.157；4.J.229.166；4.J.229.169；4.J.229.172；4.J.229.175；4.J.229.240；4.J.229.244；4.J.230.228；4.J.230.229；4.J.230.230；4.J.230.231；4.J.230.236；4.J.230.237；4.J.230.238；4.J.230.239；4.J.230.154；4.J.230.157；4.J.230.166；4.J.230.169；4.J.230.172；4.J.230.175；4.J.230.240；4.J.230.244；4.J.231.228；4.J.231.229；4.J.231.230；4.J.231.231；4.J.231.236；4.J.231.237；4.J.231.238；4J.231.239；4.J.231.154；4.J.231.157；4.J.231.166；4.J.231.169；4.J.231.172；4.J.231.175；4.J.231.240；4.J.231.244；4.J.236.228；4.J.236.229；4.J.236.230；4.J.236.231；4.J.236.236；4.J.236.237；4.J.236.238；4.J.236.239；4.J.236.154；4.J.236.157；4.J.236.166；4.J.236.169；4.J.236.172；4.J.236.175；4.J.236.240；4.J.236.244；4.J.237.228；4.J.237.229；4.J.237.230；4.J.237.231；4.J.237.236；4.J.237.237；4.J.237.238；4.J.237.239；4.J.237.154；4.J.237.157；4.J.237.166；4.J.237.169；4.J.237.172；4.J.237.175；4.J.237.240；4.J.237.244；4.J.238.228；4.J.238.229；4.J.238.230；4.J.238.231；4.J.238.236；4.J.238.237；4.J.238.238；4.J.238.239；4.J.238.154；4.J.238.157；4.J.238.166；4.J.238.169；4.J.238.172；4.J.238.175；4.J.238.240；4.J.238.244；4.J.239.228；4.J.239.229；4.J.239.230；4.J.239.231；4.J.239.236；4.J.239.237；4.J.239.238；4.J.239.239；4.J.239.154；4.J.239.157；4.J.239.166；4.J.239.169；4.J.239.172；4.J.239.175；4.J.239.240；4.J.239.244；4.J.154.228；4.J.154.229；4.J.154.230；4.J.154.231；4.J.154.236；4.J.154.237；4.J.154.238；4.J.154.239；4.J.154.154；4.J.154.157；4.J.154.166；4.J.154.169；4.J.154.172；4.J.154.175；4.J.154.240；4.J.154.244；4.J.157.228；4.J.157.229；4.J.157.230；4.J.157.231；4.J.157.236；4.J.157.237；4.J.157.238；4.J.157.239；4.J.157.154；4.J.157.157；4.J.157.166；4.J.157.169；4.J.157.172；4.J.157.175；4.J.157.240；4.J.157.244；4.J.166.228；4.J.166.229；4.J.166.230；4.J.166.231；4.J.166.236；4.J.166.237；4.J.166.238；4.J.166.239；4.J.166.154；4.J.166.157；4.J.166.166；4.J.166.169；4.J.166.172；4.J.166.175；4.J.166.240；4.J.166.244；4.J.169.228；4.J.169.229；4.J.169.230；4.J.169.231；4.J.169.236；4.J.169.237；4.J.169.238；4.J.169.239；4.J.169.154；4.J.169.157；4.J.169.166；4.J.169.169；4.J.169.172；4.J.169.175；4.J.169.240；4.J.169.244；4.J.172.228；4.J.172.229；4.J.172.230；4.J.172.231；4.J.172.236；4.J.172.237；4.J.172.238；4.J.172.239；4.J.172.154；4.J.172.157；4.J.172.166；4.J.172.169；4.J.172.172；4.J.172.175；4.J.172.240；4.J.172.244；4.J.175.228；4.J.175.229；4.J.175.230；4.J.175.231；4.J.175.236；4.J.175.237；4.J.175.238；4.J.175.239；4.J.175.154；4.J.175.157；4.J.175.166；4.J.175.169；4.J.175.172；4.J.175.175；4.J.175.240；4.J.175.244；4.J.240.228；4.J.240.229；4.J.240.230；4.J.240.231；4.J.240.236；4.J.240.237；4.J.240.238；4.J.240.239；4.J.240.154；4.J.240.157；4.J.240.166；4.J.240.169；4.J.240.172；4.J.240.175；4.J.240.240；4.J.240.244；4.J.244.228；4.J.244.229；4.J.244.230；4.J.244.231；4.J.244.236；4.J.244.237；4.J.244.238；4.J.244.239；4.J.244.154；4.J.244.157；4.J.244.166；4.J.244.169；4.J.244.172；4.J.244.175；4.J.244.240；4.J.244.244；4.L的前體藥物4.L.228.228；4.L.228.229；4.L.228.230；4.L.228.231；4.L.228.236；4.L.228.237；4.L.228.238；4.L.228.239；4.L.228.154；4.L.228.157；4.L.228.166；4.L.228.169；4.L.228.172；4.L.228.175；4.L.228.240；4.L.228.244；4.L.229.228；4.L.229.229；4.L.229.230；4.L.229.231；4.L.229.236；4.L.229.237；4.L.229.238；4.L.229.239；4.L.229.154；4.L.229.157；4.L.229.166；4.L.229.169；4.L.229.172；4.L.229.175；4.L.229.240；4.L.229.244；4.L.230.228；4.L.230.229；4.L.230.230；4.L.230.231；4.L.230.236；4.L.230.237；4.L.230.238；4.L.230.239；4.L.230.154；4.L.230.157；
4.L.230.166；4.L.230.169；4.L.230.172；4.L.230.175；4.L.230.240；4.L.230.244；4.L.231.228；4.L.231.229；4.L.231.230；4.L.231.231；4.L.231.236；4.L.231.237；4.L.231.238；4.L.231.239；4.L.231.154；4.L.231.157；4.L.231.166；4.L.231.169；4.L.231.172；4.L.231.175；4.L.231.240；4.L.231.244；4.L.236.228；4.L.236.229；4.L.236.230；4.L.236.231；4.L.236.236；4.L.236.237；4.L.236.238；4.L.236.239；4.L.236.154；4.L.236.157；4.L.236.166；4.L.236.169；4.L.236.172；4.L.236.175；4.L.236.240；4.L.236.244；4.L.237.228；4.L.237.229；4.L.237.230；4.L.237.231；4.L.237.236；4.L.237.237；4.L.237.238；4.L.237.239；4.L.237.154；4.L.237.157；4.L.237.166；4.L.237.169；4.L.237.172；4.L.237.175；4.L.237.240；4.L.237.244；4.L.238.228；4.L.238.229；4.L.238.230；4.L.238.231；4.L.238.236；4.L.238.237；4.L.238.238；4.L.238.239；4.L.238.154；4.L.238.157；4.L.238.166；4.L.238.169；4.L.238.172；4.L.238.175；4.L.238.240；4.L.238.244；4.L.239.228；4.L.239.229